- Production of carboxylic acid and carboxylic acid ester allylation intermediate
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The invention discloses a preparation method of aryl/alkyl carboxylic acid which serves as a useful intermediate of a polymerized liquid crystal compound and is provided with (methyl) propene acyloxy, and aryl/alkyl allyl carboxylate which serves as an in
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Paragraph 0071; 0072
(2019/06/04)
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- METHOD FOR MANUFACTURING P-HYDROXY BENZOIC ACID ALLYL POLYMER
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PROBLEM TO BE SOLVED: To provide a method for efficiently manufacturing p-hydroxy benzoic acid allyl polymer having high antibacterial property. SOLUTION: There is provided a method for manufacturing p-hydroxy benzoic acid allyl polymer including (A) a pr
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Paragraph 0049
(2017/02/24)
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- A simple FRET-based modular design for diagnostic probes
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In recent years, there has been a massive effort to develop molecular probes with optical modes of action. Probes generally produce detectable signals based on changes in fluorescence properties. Here, we demonstrate the potential of self-immolative molecular adaptors as a platform for Turn-On probes based on the FRET technique. The probe is equipped with identical fluorophore pairs or a fluorophore/quencher FRET pair and a triggering substrate. Upon reaction of the analyte of interest with the triggering substrate, the self-immolative adaptor spontaneously releases the two dye molecules to break off the FRET effect. As a result, a new measurable fluorescent signal is generated. The fluorescence obtained can be used to quantify the analyte. The modular structure of the probe design will allow the preparation of various chemical probes based on the FRET activation technique.
- Redy, Orit,Kisin-Finfer, Einat,Sella, Eran,Shabat, Doron
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supporting information; scheme or table
p. 710 - 715
(2012/02/05)
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- (Meth)acrylate compound, curable composition using the same, curable composition for photo-nanoimprints, cured product of curable composition and method for manufacturing cured product
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It's object is to provide a (meth)acrylate compound excellent in photocurability, a curable composition comprising the compound and excellent in all of pattern accuracy, peelability, surface hardness, elasticity recovery and solvent resistance, an optical
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Page/Page column 34
(2012/11/06)
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- Synthesis of para-substituted bicyclo[2.2.1]hept-5-en-2-ylmethyl benzoates
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para-Substituted bicyclo[2.2.1]hept-5-en-2-ylmethyl benzoates were synthesized by the Diels-Alder reaction of cyclopentadiene with the corresponding para-substituted allyl benzoates, and optimal reaction conditions were found. The product structure was confirmed by independent synthesis and IR and 1H NMR spectroscopy.
- Mamedbeili,Kyazimova,Nagiev,Abdiev,Aliev
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experimental part
p. 74 - 77
(2009/07/17)
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- Synthesis of novel aromatic macrolactones via ring closing metathesis of substituted phenylalkanoic acid allylic esters
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(Chemical Equation Presented) Stable aromatic macrolactones have been synthesized and characterized from 2- and 3-substituted phenylalkanoic acid systems in modest yields.
- Brown, David P.,Duong, Hoan Q.
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p. 435 - 443
(2008/09/19)
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- Synthesis and photostabilizing properties of hexachlorobicyclo[2.2.1]hept- 5-enylmethyl esters of substituted benzoic acids
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Polychlorinated bicyclic esters of p-substituted benzoic acids were prepared by the Diels-Alder reaction of hexachlorocyclopentadiene with allyl esters of p-substituted benzoic acids. Some of the adducts synthesized were tested as photostabilizers for polyethylene-based polymer formulations.
- Kyazimova,Mamedov,Babaev,Mamedova
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p. 438 - 442
(2008/09/20)
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- Design and synthesis of phosphotyrosine peptidomimetic prodrugs
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A novel approach to the intracellular delivery of aryl phosphates has been developed that utilizes a phosphoramidate-based prodrug approach. The prodrugs contain an ester group that undergoes reductive activation intracellularly with concomitant expulsion
- Garrido-Hernandez, Hugo,Moon, Kyung D.,Geahlen, Robert L.,Borch, Richard F.
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p. 3368 - 3376
(2007/10/03)
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- Allylation of Alcohols and Carboxylic Acids with Allyl Acetate Catalyzed by [Ir(cod)2]+BF4- Complex
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A facile method for the synthesis of allyl alkyl ethers from alcohols with allyl acetate was developed by the use of [Ir(cod)2] +BF4- complex. For instance, the reaction of allyl acetate with n-octyl alcohol in the presence of a catalytic amount of [Ir(cod)2]+BF4- complex afforded allyl octyl ether in quantitative yield. Allyl carboxylates were also prepared by the exchange reaction between carboxylic acids and allyl acetate in good yields. The [Ir(cod)2]+BF4- complex catalyzed the reaction of alkyl and aromatic amines with allyl acetate to lead to the corresponding allylamines in fair to good yields.
- Nakagawa, Hideto,Hirabayashi, Tomotaka,Sakaguchi, Satoshi,Ishii, Yasutaka
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p. 3474 - 3477
(2007/10/03)
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- Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A2 based on a 1,3-disubstituted propan-2-one skeleton
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Using knowledge of the substrate specificity of cPLA2 (phospholipases A2), a novel series of inhibitors of this enzyme were designed based upon a three point model of inhibitor binding to the enzyme active site comprising a lipophilic anchor, an electrophilic serine "trap", and an acidic binding moiety. The resulting 1,3-diheteroatom-substituted propan-2-ones were evaluated as inhibitors of cPLA2 in both aggregated bilayer and soluble substrate assays. Systematic variation of the lipophilic, electrophilic, and acidic groups revealed a well-defined structure-activity relationship against the enzyme. Optimization of each group led to compound 22 (AR-C70484XX), which contains a decyloxy lipophilic side chain, a 1,3-diaryloxypropan-2-one moiety as a unique serine trap, and a benzoic acid as the acidic binding group. AR-C70484XX was found to be among the most potent in vitro inhibitors of cPLA2 described to date being more than 20-fold more active against the isolated enzyme (IC50 = 0.03 μM) than the standard cPLA2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3), and also greater than 10-fold more active than AACOCF3 against the cellular production of arachidonic acid by HL60 cells (IC50 = 2.8 μM).
- Connolly, Stephen,Bennion, Colin,Botterell, Sarah,Croshaw, Pamela J.,Hallam, Catherine,Hardy, Kim,Hartopp, Paul,Jackson, Clive G.,King, Sarah J.,Lawrence, Louise,Mete, Antonio,Murray, David,Robinson, David H.,Smith, Gillian M.,Stein, Linda,Walters, Iain,Wells, Edward,Withnall, W. John
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p. 1348 - 1362
(2007/10/03)
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- Efficient synthesis of resin-bound α-TMSdiazoketones and their use in solid-phase organic synthesis
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α-TMSdiazoketones on a solid support could be simply and efficiently prepared by reaction of the corresponding resin-bound acid chlorides with excess TMSdiazomethane, without any bases. These α-TMSdiazoketones were used via carbenes or carbenoids for a variety of solid-phase reactions. These useful solid-phase reactions allow efficient construction of diverse compound libraries by use of combinatorial chemistry, due to the high reactivity and wide applications of the carbenes or carbenoids. (C) 2000 Elsevier Science Ltd.
- Iso, Yasuyoshi,Shindo, Hirohisa,Hamana, Hiroshi
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p. 5353 - 5361
(2007/10/03)
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- An improved method for preparation of carboxylic esters using CsF- celite/alkyl halide/CH3CN combination
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A new method for efficient and chemoselective esterification of carboxylic acids in CsF-Celite/alkyl halide/CH3CN reaction system is described.
- Lee, Jong Chan,Choi, Youngsup
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p. 2021 - 2026
(2007/10/03)
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- Channel-Type Molecular Structures Part 2 Synthesis of Bouquet-Shaped Molecules Based on a β-Cyclodextrin Core
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A new series of channel-type molecules presenting the features of potential transmembrane structures is described.They result from the grafting of amphiphilic side chains on a β-cyclodextrin derivative 3 that constitutes the organizing core.They belong to the 'bouquet' family (B).Compounds bearing poly(oxyethylene) side chains, BOCD 16 and 17, and their polymethylene analogues BCCD 18 and 19, were synthesized.The properties investigated emphasize the suitability of such molecules to be incorporated into lipid bilayer membranes.
- Canceill, Josette,Jullien, Ludovic,Lacombe, Liliane,Lehn, Jean-Marie
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p. 791 - 812
(2007/10/02)
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- METHOD FOR TREATMENT OR PROPHYLAXIS OF CARDIAC DISORDERS
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A method for the treatment of prophylaxis of cardiac disorders in a mammal, comprising administering to such mammal a short-acting β-blocking compound of the formula: STR1 wherein R may be lower alkyl, aryl, or aralkyl; n may be an integer from 0 to about 10; x may be an integer from 1 to 3; Ar may be substituted or unsubstituted aromatic; R. sub.1 may be lower alkyl, or aralkyl; and pharmaceutically accepted salts thereof. Novel compounds possessing short-acting β-adrenergic blocking activity are also disclosed.
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