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6-PHENYL-2-PYRIDONE, also known as 6-Phenylpyridin-2(1H)-one, is an organic compound with a molecular structure that features a pyridinone core fused with a phenyl ring. It is a versatile chemical intermediate with potential applications in various industries due to its unique chemical properties.

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  • 19006-82-7 Structure
  • Basic information

    1. Product Name: 6-PHENYL-2-PYRIDONE
    2. Synonyms: 2-HYDROXY-6-PHENYLPYRIDINE;6-PHENYL-2-PYRIDONE;Phenylpyridone;6-phenyl-2-pyridone95+%;6-PHENYL-2-PYRIDONE 95+% T;6-Phenyl-2(1H)-pyridinone;6-Phenyl-2(1H)-pyridone;6-Phenylpyridine-2-ol
    3. CAS NO:19006-82-7
    4. Molecular Formula: C11H9NO
    5. Molecular Weight: 171.2
    6. EINECS: 242-740-9
    7. Product Categories: N/A
    8. Mol File: 19006-82-7.mol
  • Chemical Properties

    1. Melting Point: 197 °C
    2. Boiling Point: 417.1 °C at 760 mmHg
    3. Flash Point: 246.1 °C
    4. Appearance: /
    5. Density: 1.158 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: Room temperature.
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-PHENYL-2-PYRIDONE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-PHENYL-2-PYRIDONE(19006-82-7)
    11. EPA Substance Registry System: 6-PHENYL-2-PYRIDONE(19006-82-7)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22-36
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 19006-82-7(Hazardous Substances Data)

19006-82-7 Usage

Uses

Used in Pharmaceutical Industry:
6-PHENYL-2-PYRIDONE is used as a reactant for the preparation of phenylaminopyrimidinones and its derivatives. These compounds serve as orally active nonpeptidic inhibitors of human neutrophil elastase, which is an enzyme involved in the degradation of elastin in tissues. Inhibition of this enzyme can be beneficial in the treatment of various inflammatory and lung diseases, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

Check Digit Verification of cas no

The CAS Registry Mumber 19006-82-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,0,0 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 19006-82:
(7*1)+(6*9)+(5*0)+(4*0)+(3*6)+(2*8)+(1*2)=97
97 % 10 = 7
So 19006-82-7 is a valid CAS Registry Number.

19006-82-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-phenyl-1H-pyridin-2-one

1.2 Other means of identification

Product number -
Other names 6-PHENYL-2-PYRIDONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:19006-82-7 SDS

19006-82-7Relevant articles and documents

Rhodium-Catalyzed C6-Selective C-H Borylation of 2-Pyridones

Miura, Wataru,Hirano, Koji,Miura, Masahiro

, p. 3742 - 3745 (2016)

A pyridine-directed, rhodium-catalyzed C6-selective C-H borylation of 2-pyridones with bis(pinacolato)diboron (pinB-Bpin) has been developed. The reaction proceeds smoothly under relatively mild conditions, and the corresponding C6-borylated 2-pyridones are obtained with perfect site selectivity. Subsequent palladium-catalyzed Suzuki-Miyaura cross-coupling is followed by the removal of the pyridine directing group to form the C6-arylated NH-pyridone in an acceptable overall yield.

Rh(I)-Catalyzed Direct C6?H Arylation of 2-Pyridones with Aryl Carboxylic Acids

Fan, Qinghua,Pan, Yixiao,Walsh, Patrick J.,Xu, Jianbin,Xu, Lijin,Xu, Xin,Yu, Zexin,Zhao, Haoqiang

, p. 3995 - 4001 (2021)

A Rh(I)-catalyzed C6-selective C?H arylation of 2-pyridones with inexpensive, readily available, safe and structurally diverse aryl carboxylic acids with the aid of a pyridine directing group is developed. This decarbonylative arylation protocol features an easy-to-handle catalytic system, and is amenable to diversely substituted 2-pyridones and aryl carboxylic acids. It allows access to a wide range of C6-arylated 2-pyridones, including those that are difficult to prepare using conventional C?H arylation processes. The method tolerates various electron-neutral, electron-rich and electron-deficient functional groups, and affords the products in 41–91% yields. (Figure presented.).

Manganese-Promoted Regioselective Direct C3-Phosphinoylation of 2-Pyridones

Chantarojsiri, Teera,Kittikool, Tanakorn,Phakdeeyothin, Kunita,Yotphan, Sirilata

supporting information, p. 3071 - 3078 (2021/07/22)

A highly efficient and regioselective manganese-induced radical oxidative direct C?P bond formation between 2-pyridones and secondary phosphine oxides was developed. The C3-selective phosphinoylation was conveniently achieved through a combination of substoichiometric manganese and persulfate oxidant under mild conditions. Various 3-phosphinoylated pyridone products can be obtained in moderate to high yields. Preliminary mechanistic studies suggest that the reaction is likely to involve a radical pathway induced by catalytically active Mn3+ species.

Vinylogous Blaise Reaction: Conceptually New Synthesis of Pyridin-2-ones

Rao, H. Surya Prakash,Muthanna, Nandurka,Padder, Ashiq Hussain

supporting information, p. 1649 - 1653 (2018/06/26)

A conceptually new synthesis of pyridine rings by a [C 4 + CN] assembly has been developed by applying a vinylogous version of the classic Blaise reaction. The zinc-mediated reaction of (het)aryl or alkyl nitriles with ethyl-4-bromocrotonate pr

Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes

Smith, Charlotte L.,Hirschh?user, Christoph,Malcolm, Georgia K.,Nasrallah, Daniel J.,Gallagher, Timothy

, p. 1904 - 1908 (2014/08/18)

Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.

8-Azabicyclo[3.2.1]octane derivatives

-

Page/Page column 9, (2008/06/13)

The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof or solvate thereof. The present invention also relates to a pharmaceutical composition comprising an 8-azabicyclo[3.2.1]octane derivative in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of the 8-azabicyclo[3.2.1]octane derivative in therapy.

8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS

-

Page/Page column 20, (2010/11/27)

The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein R1 is H or C1-5alkyl; Y is O, S or O(CH2)m; m is 1 or 2; n is 0 or 1; Ar1 is phenylene or pyridylene, said phenylene and pyridylene being 1,3-linked with respect to O and when n is 1 with Y and when n is 0 with Ar2, said phenylene or pyridylene being optionally substituted with one or two substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, phenyl, CN and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar2 to form a 5-membered ring; Ar2 is phenyl or a 5-6 membered heteroaryl, said phenyl or 5-6 membered heteroaryl being optionally substituted with one to three substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, CN, CONR2R3, CO2R4, NHCOR5 and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar1 to form a 5-membered ring; R2-R4 are independently H or C1-5alkyl and R5 is C1-5alkyl, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising a 8- azabicyclo[3.2.1]octane derivative according to the present invention in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of a 8- azabicyclo[3.2.1]octane derivative according to the present invention in therapy.

PLATINUM COMPLEX AND LUMINESCENT ELEMENT

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Page/Page column 24-25, (2008/06/13)

Provision of a novel platinum complex which is useful as a material for a light-emitting device of good light emission characteristic and light emission efficiency, and a novel light-emitting material that may be utilized in various fields. A platinum complex represented by the following general formula (1): (in which two rings of ring A, ring B, ring C, and ring D represent nitrogen-containing heterocyclic rings which may have a substituent and the remaining two rings of them represent aryl rings or hetero aryl rings which may have a substituent, the ring A and the ring B, the ring A and the ring C or/and the ring B and the rind D may form condensed rings. Two of X1, X2, X3, and X4 represent nitrogen atoms coordination bonded to a platinum atom and the remaining two of them represent carbon atoms or nitrogen atoms. Q1, Q2, and Q3 each represents a bond, oxygen atom, sulfur atom or bivalent group, two of Z1, Z2, Z3, and Z4 represent coordination bonds, and the remaining two of them represent covalent bonds, oxygen atoms or sulfur atoms), and a light-emitting device containing the platinum complex.

Herbicidal 2-(hectero)aryloxy-6-arypyridines and 2-aryl-4-(hetero)aryloxypyrimidines

-

, (2008/06/13)

New herbicidal pyridine and pyrimidine derivatives of general formula (I), STR1 wherein Z represents a nitrogen atom or a C--H group; A represents an optionally substituted aryl group or an optionally substituted 5- or 6-membered nitrogen-containing heteroaromatic group; n represents an integer from 0 to 2 and R1 or each R1 independently represents a hydrogen atom or an optionally substituted alkyl, alkoxy, alkylthio or dialkylamino group; m represents an integer from 0 to 5 and R2 or each R2 independently represents a hydrogen or a halogen atom or an optionally substituted alkyl, haloalkyl, haloalkoxy, alkoxy, alkylthio group or a nitro, cyano or a halosulphonyl group; and X represents an oxygen or sulphur atom.

Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines

-

, (2008/06/13)

New herbicidal pyrimidine derivatives of general formula (I), STR1 wherein Z represents a nitrogen atom; A represents a substituted aryl group or an optionally substituted pyridyl or pyrazolyl group; n represents an integer from 0 to 2 and R1 or each R1 independently represents a hydrogen atom or an optionally substituted alkyl, alkoxy, alkylthio or dialkylamino group; m represents an integer from 0 to 5 and R2 or each R2 independently represents a hydrogen or a halogen atom or an optionally substituted alkyl, haloalkyl, haloalkoxy, alkoxy, alkylthio group or a nitro, cyano or a halosulphonyl group; and X represents an oxygen or sulphur atom.

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