192384-87-5Relevant articles and documents
Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: Impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, α2A, D4.2, D3 and D2L receptors
Résimont, Mélissa,Liégeois, Jean-Fran?ois
scheme or table, p. 5199 - 5202 (2010/10/03)
A series of carboxamide and sulphonamide alkyl(ethyl to hexyl)piperazine analogues were prepared and tested for their affinity to bind to a range of receptors potentially involved in psychiatric disorders. These chemical modifications led us to explore th
N-(ω)-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands
Hackling, Anneke,Ghosh, Robin,Perachon, Sylvie,Mann, André,H?ltje, Hans-Dieter,Wermuth, Camille G.,Schwartz, Jean-Charles,Sippl, Wolfgang,Sokoloff, Pierre,Stark, Holger
, p. 3883 - 3899 (2007/10/03)
The dopamine D3 receptor is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders. Targetting high affinity and D3 versus D2 receptor-preferring ligands, the parti
2-NAPHTHAMIDE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
-
, (2008/06/13)
The invention related to 2-naphthamide derivatives, in the form of bases or of salts, corresponding to the following general formula (I): STR1 in which: the Z--Y entity represents an N--CH 2, C= CH or CH--CH. sub.2 group;R 1 represents a hydrogen, f