192436-83-2

Basic information

• Product Name: 4-BROMO-N-METHOXY-N-METHYLBENZAMIDE
• Synonyms: 4-BROMO-N-METHOXY-N-METHYLBENZAMIDE;4-[Methoxy(methyl)carbamoyl]bromobenzene
• CAS NO: 192436-83-2
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.09
• Mol File: 192436-83-2.mol

Chemical Properties

• Boiling Point: 351.534 °C at 760 mmHg
• Flash Point: 166.402 °C
• Appearance: /
• Density: 1.459 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5680 to 1.5720
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-BROMO-N-METHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-N-METHOXY-N-METHYLBENZAMIDE(192436-83-2)
• EPA Substance Registry System: 4-BROMO-N-METHOXY-N-METHYLBENZAMIDE(192436-83-2)

Safety Data

• Hazardous Substances Data: 192436-83-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
4-BROMO-N-METHOXY-N-METHYLBENZAMIDE is used as a building block for the synthesis of drug molecules, contributing to the development of new pharmaceuticals. Its unique structure allows for the creation of compounds with specific therapeutic properties, making it a valuable asset in the advancement of medicinal chemistry.
Used in Agrochemical Research and Development:
In the agrochemical industry, 4-BROMO-N-METHOXY-N-METHYLBENZAMIDE is utilized as an intermediate in the synthesis of compounds with potential applications in agriculture. Its role in the development of new agrochemicals can lead to more effective and targeted pest control solutions, enhancing crop protection and yield.
Used in Organic Synthesis:
As an intermediate in organic synthesis, 4-BROMO-N-METHOXY-N-METHYLBENZAMIDE is employed in the production of a variety of organic compounds. Its versatility in chemical reactions enables the synthesis of a wide range of molecules, broadening its applications across different industries and research areas.

InChI:InChI=1/C9H10BrNO2/c1-11(13-2)9(12)7-3-5-8(10)6-4-7/h3-6H,1-2H3

Upstream product

• 586-75-4 4-chlorobenzoyl chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 586-76-5 4-Bromobenzoic acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 201230-82-2 carbon monoxide 
• 589-87-7 1,4-bromoiodobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 321970-34-7 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonic acid 4-bromophenyl ester 
• 1380243-00-4 3-(4-bromobenzoyl) oxazolidin-2-one 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 131895-07-3 1-(4-bromophenyl)-3-methylbutan-1-one 
• 99-90-1 para-bromoacetophenone 
• 7295-44-5 4'-bromovalerophenone 
• 184165-64-8 1-(4-bromophenyl)-3-buten-1-one 
• 2001-29-8 1-(4-bromophenyl)-2-phenyl-ethan-1-one 
• 161581-93-7 (4-bromo-phenyl)-(3-fluoro-4-methoxy-phenyl)-methanone 
• 4160-65-0 (4-bromophenyl)(thien-2-yl)methanone 
• 1178521-37-3 C₁₂H₆BrF₂NO 
• 1186220-85-8 3-(2-(4-bromobenzoyl)phenyl)-4-trimethylsilylsydnone 
• 22731-70-0 1-(4-bromophenyl)prop-2-en-1-one 
• 284665-01-6 1-(4-bromophenyl)hex-5-en-1-one 
• 2138-34-3 1-(4-bromo-phenyl)-3-dimethylamino-propan-1-one 
• 623-00-7 4-bromobenzenecarbonitrile 
• 14548-45-9 (4-bromophenyl)-pyridin-3-yl-methanone 

Relevant articles and documents

Poly(vinyl ketone)s by controlled boron group transfer polymerization (BGTP)

(Figure Presented) Boron can do it! Readily prepared catecholboron enolates act as regulators in the controlled radical polymerization of alkyl and aryl vinyl ketones. Control is achieved by an unprecedented reversible radical boron group transfer (BGT) between enoyl radicals (see scheme). Polymers with M n-1 and a polydispersity index of 1.3 can be obtained by this process.

NOVEL COMPOUNDS HAVING ANTI-INFLAMMATORY ACTIVITY AS P38 MAP KINASE INHIBITOR

The present invention relates to novel compounds exhibiting anti-inflammatory activity. The compound of the present invention plays a critical role in the production of inflammatory prodrug (pro-inflammatory cytokines) and has an excellent inhibitory effect on p38 MAPK, which is known to cause inflammatory diseases, and thus can be used as a therapeutic agent for inflammatory diseases.

Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination

Rhodium-electrocatalyzed arene C?H oxygenation by weakly O-coordinating amides and ketones have been established by bimetallic electrocatalysis. Likewise, diverse dihydrooxazinones were selectively accessed by the judicious choice of current, enabling twofold C?H functionalization. Detailed mechanistic studies by experiment, mass spectroscopy and cyclovoltammetric analysis provided support for an unprecedented electrooxidation-induced C?H activation by a bimetallic rhodium catalysis manifold.

Acetyl nitrate mediated conversion of methyl ketones to diverse carboxylic acid derivatives

The development of a novel acetyl nitrate mediated oxidative conversion of methyl ketones to carboxylic acid derivatives is described. By analogy to the haloform reaction and supported by experimental and computational investigation we propose a mechanism for this transformation.

Fluoro-Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors

The external quenching method based on flow microreactors allows the generation and use of short-lived fluoro-substituted methyllithium reagents, such as fluoromethyllithium, fluoroiodomethyllithium, and fluoroiodostannylmethyllithium. Highly chemoselective reactions have been developed, opening new opportunities in the synthesis of fluorinated molecules using fluorinated organometallics.

An α-Cyclopropanation of Carbonyl Derivatives by Oxidative Umpolung

The reactivity of iodine(III) reagents towards nucleophiles is often associated with umpolung and cationic mechanisms. Herein, we report a general process converting a range of ketone derivatives into α-cyclopropanated ketones by oxidative umpolung. Mechanistic investigation and careful characterization of side products revealed that the reaction follows an unexpected pathway and suggests the intermediacy of non-classical carbocations.

Synthesis of various acylating agents directly from carboxylic acids

A straightforward synthesis of acylating reagents such as Weinreb and MAP amides from aromatic, aliphatic carboxylic acids, and amino acids using PPh3/NBS combination is described. A chemo-selective modification of the carboxylic acid group into Weinreb amide in the presence of more reactive aldehydes and ketones is presented. All reactions were performed at ambient temperature under air using undried commercial grade solvent. Furthermore, the present methodology could be performed at a gram scale under inert-free reaction conditions. In addition, 7-azaindoline amide auxiliary (used for catalytic asymmetric aldol- and Mannich-type reactions), which behaves like Weinreb amide is also synthesized under similar reaction conditions.

Saturated Bioisosteres of ortho-Substituted Benzenes

Saturated bioisosteres of ortho-disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The

Iminyl Radicals by Reductive Cleavage of N-O Bond in Oxime Ether Promoted by SmI2: A Straightforward Synthesis of Five-Membered Cyclic Imines

A new generation method of N-centered radicals from the reductive cleavage of the N-O bond in oxime ether promoted by SmI2 is reported for the first time. The in-situ-generated N-centered radicals underwent intramolecular cyclization to afford five-membered cyclic imines in two manners: N-centered radical addition and N-centered anion nucleophilic substitution. From a synthetic point of view, an efficient synthetic method of five-membered cyclic imines was developed. A mechanism of the transformation was proposed.

DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS

Compounds of formula (I) which are nicotinamide phosphoribosyltransferase (NAMPT) inhibitors and their use for the treatment of hyperproloferative diseases and/or disorders responsive to induction of cell death.