19786-48-2

Basic information

• Product Name: (4-Nitrophenoxy)acetic acid methyl ester
• Synonyms: (4-Nitrophenoxy)acetic acid methyl ester;4-Nitrophenoxyacetic acid methyl ester
• CAS NO: 19786-48-2
• Molecular Formula: C₉H₉NO₅
• Molecular Weight: 211.18
• Mol File: 19786-48-2.mol

Chemical Properties

• Melting Point: 99 °C
• Boiling Point: 337.4±17.0 °C(Predicted)
• Appearance: /
• Density: 1.305±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (4-Nitrophenoxy)acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Nitrophenoxy)acetic acid methyl ester(19786-48-2)
• EPA Substance Registry System: (4-Nitrophenoxy)acetic acid methyl ester(19786-48-2)

Safety Data

• Hazardous Substances Data: 19786-48-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(4-Nitrophenoxy)acetic acid methyl ester is used as an intermediate in the synthesis of isotopically labeled analogues of pharmaceutical compounds. It plays a vital role in the production of 2-(4-(Methylsulfonamido)phenoxy)acetic Acid-13C (M332217), which is an isotopically labeled analogue of 2-(4-(Methylsulfonamido)phenoxy)acetic Acid (M332215). This metabolite is derived from the antiarrhythmic drug Dofetilide (D525700), a potassium channel blocker.
Used in the Synthesis of Dofetilide Metabolites:
(4-Nitrophenoxy)acetic acid methyl ester is used as a key component in the synthesis of metabolites of Dofetilide, an antiarrhythmic drug. This application is significant in the development and understanding of the drug's pharmacokinetics, pharmacodynamics, and potential side effects, as well as in the design of new drugs with improved efficacy and safety profiles.
Used in the Chemical Industry:
In the chemical industry, (4-Nitrophenoxy)acetic acid methyl ester may be utilized as a building block for the synthesis of various organic compounds, including those with potential applications in materials science, agrochemicals, and other specialized fields. Its reactivity and functional groups make it a versatile starting material for the development of new molecules with specific properties and applications.

Upstream product

• 67-56-1 methanol 
• 20142-88-5 2-(4-nitrophenoxy)acetyl chloride 
• 100-02-7 4-nitro-phenol 
• 124-41-4 sodium methylate 
• 105-39-5 chloroacetic acid ethyl ester 
• 96-32-2 bromoacetic acid methyl ester 
• 1798-11-4 4-nitrophenoxyacetic acid 
• 96-34-4 methyl chloroacetate 

Downstream Products

• 50508-33-3 1-(morpholin-4-yl)-2-(4-nitrophenoxy)ethanone 
• 76870-09-2 2-(4-aminophenoxy)-1-morpholinoethanone 
• 20916-22-7 N-(4-chlorophenyl)-2-(4-nitrophenoxy)acetamide 
• 881607-14-3 2-(4-aminophenoxy)-N-(4-chlorophenyl)acetamide 

Relevant articles and documents

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