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6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative characterized by the presence of a bromine atom at the 6th position, a hydroxyl group at the 2nd position, and a methoxy group at the 3rd position. It is known for its involvement in the synthesis of various organic compounds and exhibits a monoclinic crystal system with a space group of P21/n.

20035-41-0

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20035-41-0 Usage

Uses

Used in Organic Synthesis:
6-Bromo-2-hydroxy-3-methoxybenzaldehyde is used as a key intermediate in the synthesis of complex organic molecules, such as 2-benzyloxy-6-bromo-3-methoxybenzaldehyde and biphenyls. Its unique functional groups and structural features make it a valuable building block for the development of new pharmaceuticals and other organic compounds.
Used in Pharmaceutical Industry:
6-Bromo-2-hydroxy-3-methoxybenzaldehyde is used as a precursor in the synthesis of antihypertensive natural products, specifically S-(+)-XJP and R-(-)-XJP. These natural products have the potential to lower blood pressure and provide therapeutic benefits for individuals suffering from hypertension.
Used in Crystallography Research:
The monoclinic crystal system and space group P21/n of 6-Bromo-2-hydroxy-3-methoxybenzaldehyde's crystals make it an interesting subject for crystallography research. Studying its crystal structure can provide insights into the arrangement of atoms and molecules, which can be useful for understanding the properties and behavior of similar compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 20035-41-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,0,3 and 5 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 20035-41:
(7*2)+(6*0)+(5*0)+(4*3)+(3*5)+(2*4)+(1*1)=50
50 % 10 = 0
So 20035-41-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H7BrO3/c1-12-7-3-2-6(9)5(4-10)8(7)11/h2-4,11H,1H3

20035-41-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE

1.2 Other means of identification

Product number -
Other names 6-bromo-3-methoxysalicylaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20035-41-0 SDS

20035-41-0Relevant articles and documents

Boron Containing PDE4 Inhibitors

-

, (2020/04/29)

The present invention relates to boron containing compounds of Formula (I) [in-line-formulae]X—Y—Z?? Formula (I)[/in-line-formulae] that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

The first total synthesis of (±)-methyl salvianolate A using a convergent strategy

Wang, Bo,Wang, Liping,Peng, Ying,Pang, Yiying,Xiao, Hesheng,Wang, Xiaoji,Huang, Shuangping

, (2019/03/19)

Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner–Wadsworth–Emmons reaction and the protection of multiple hydroxyls using s

Fibrauretine synthetic method (by machine translation)

-

Paragraph 0044; 0045; 0062, (2018/09/21)

The invention relates to O-vanillin (11) as the starting material, by the acylation reaction generating 2 - acetoxy - 3 - methoxybenzaldehyde (12), by the bromo, hydrolysis reaction to produce the 2 - hydroxy - 6 - bromo - 3 - methoxybenzaldehyde (13), produced by the methylation reaction 6 - bromo - 2, 3 - dimethoxy benzaldehyde (14), produced by the condensation reaction of 2 - (6 - bromo - 2, 3 - dimethoxyphenyl) - 1, 3 - dioxolane (15); and then to 3, 4 - dimethoxy acetic acid (21) as raw materials, generated by the reduction reaction of the 3, 4 - dimethoxy ethanol (22), the acylation reaction generated by 3, 4 - dimethoxy new valeric acid environmentally (23), the acylation reaction is generated by the 2 - ethoxy - 3, 4 - dimethoxy new valeric acid environmentally (24), intermediate (15) and (24) after coupling, cyclized two-step reaction process for preparing the target product fibrauretin. (by machine translation)

Salvianolic acid A intermediate and preparation method thereof

-

, (2018/09/08)

The invention relates to a medicine salvianolic acid A intermediate used for treating angina and acute myocardial infarction, i.e., a new synthesis method for trans-3-bromo-2-(3,4-di-substituted styryl)-6-substituted phenol. The method comprises the follo

Synthesis of (+)-salvianolic acid A from sodium Danshensu

Xu, Kai,Liu, Hao,Liu, Delong,Sheng, Cheng,Shen, Jiefeng,Zhang, Wanbin

, p. 5996 - 6002 (2018/09/06)

(+)-Salvianolic acid A, one of the most active components in the traditional Chinese medicine Danshen, has been synthesized over 10 steps in 6.5% overall yield. Starting from inexpensive ortho-vanillin and sodium Danshensu (synthesized via asymmetric catalysis in our group), the process consists of the following: A Wittig reaction that gives the desire product with absolute E-configuration, a demethylation reaction with AlCl3 in a satisfactory yield, and a practical deprotection of allylic groups to afford the terminal product (+)-salvianolic acid A. The current synthetic technology possesses the advantages of using inexpensive starting materials, mild reaction conditions and has the potential for use in large scale synthesis.

Atropoenantioselective redox-neutral amination of biaryl compounds through borrowing hydrogen and dynamic kinetic resolution

Zhang, Jianwei,Wang, Jian

supporting information, p. 465 - 469 (2017/12/15)

We report herein a novel atropoenantioselective redox-neutral amination of biaryl compounds triggered by a cascade of borrowing hydrogen and dynamic kinetic resolution under the cooperative catalysis of a chiral iridium complex and an achiral Br?nsted acid. This protocol features broad substrate scope and good functional-group tolerance, and allows the rapid assembly of axially chiral biaryl compounds in good to high yields and with high to excellent enantioselectivity.

Atropoenantioselective Redox-Neutral Amination of Biaryl Compounds through Borrowing Hydrogen and Dynamic Kinetic Resolution

Zhang, Jianwei,Wang, Jian

supporting information, p. 465 - 469 (2018/02/21)

We report herein a novel atropoenantioselective redox-neutral amination of biaryl compounds triggered by a cascade of borrowing hydrogen and dynamic kinetic resolution under the cooperative catalysis of a chiral iridium complex and an achiral Br?nsted acid. This protocol features broad substrate scope and good functional-group tolerance, and allows the rapid assembly of axially chiral biaryl compounds in good to high yields and with high to excellent enantioselectivity.

Ruthenium-Catalyzed Atropoenantioselective Synthesis of Axial Biaryls via Reductive Amination and Dynamic Kinetic Resolution

Guo, Donghui,Zhang, Jianwei,Zhang, Bei,Wang, Jian

supporting information, p. 6284 - 6288 (2018/10/05)

The unprecedented ruthenium-catalyzed atropoenantioselective reductive amination of aldehydes with alkylamines via a cascade transfer hydrogenation and dynamic kinetic resolution strategy is described. This protocol features broad substrate scope and good functional group tolerance and allows the rapid assembly of axially chiral biaryls in good to high yields with high to excellent enantioselectivities. In addition, such structural motifs may have potential applications in enantioselective catalysis as chiral ligands or catalysts.

Method for synthesizing natural product salvianolic acid A methyl ester

-

, (2017/07/20)

The invention relates to a novel method for synthesizing natural product salvianolic acid A methyl ester. A synthetic route is unique and novel in design; key strategies and steps comprise the step of using an easily-removed t-butyldimethylsilyl protectin

New synthesis method of natural product Salvianolic Acid F

-

, (2018/01/04)

The invention discloses a new synthesis method of a natural product Salvianolic Acid F. The method comprises the following steps: carrying out hydroxyl group protection on 4-methycatechol used as a raw material, carrying out a methyl radical reaction, and

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