200630-96-2

Basic information

• Product Name: N-(3-Acetylphenyl)-N-ethylacetaMide
• Synonyms: N-(3-Acetylphenyl)-N-ethylacetaMide
• CAS NO: 200630-96-2
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Product Categories: Aromatics, Miscellaneous Reagents
• Mol File: 200630-96-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: N-(3-Acetylphenyl)-N-ethylacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Acetylphenyl)-N-ethylacetaMide(200630-96-2)
• EPA Substance Registry System: N-(3-Acetylphenyl)-N-ethylacetaMide(200630-96-2)

Safety Data

• Hazardous Substances Data: 200630-96-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-Acetylphenyl)-N-ethylacetamide is used as a reactant for the preparation of 5-Oxo-Zaleplon (O870470), which is a metabolite of Zaleplon (Z145000). This application is significant in the development and synthesis of new pharmaceutical compounds, potentially contributing to advancements in the treatment of various medical conditions.

Upstream product

• 557-20-0 diethylzinc 
• 75-36-5 acetyl chloride 
• 121-89-1 3-Nitroacetophenone 
• 98-86-2 acetophenone 
• 74-96-4 ethyl bromide 
• 7463-31-2 3-Acetamidoacetophenone 
• 75-03-6 ethyl iodide 

Downstream Products

• 1158910-07-6 N-(3-(1-(2-(4-chlorophenoxy)phenylamino)ethyl)phenyl)-N-ethylacetamide 
• 96605-66-2 N-{3-[3-(dimethylamino)prop-2-enoyl]phenyl}-N-ethylacetamide 

Relevant articles and documents

Electrophilic Amination with Nitroarenes

An exceptionally general electrophilic amination, which directly transforms commercially available nitroarenes into alkylated aromatic aminoboranes with zinc organyl compounds was developed. The reaction starts with a two-step partial reduction of the nitro group to a nitrenoid, which is used in situ as the electrophilic amination reagent. To facilitate isolation, the resulting air- and moisture-sensitive aminoboranes were reacted with a range of electrophiles. The method not only represents a direct transformation of nitro compounds into electrophilic amination reagents but also provides an elegant alternative to dehydrocoupling methods for the generation of aminoboranes.

A new method for synthesizing zaleplon (by machine translation)

The present invention provides a new method for synthesizing zaleplon. In particular, the method of the invention takes the acetophenone as raw materials, make N-ethyl-N-[ 3 - (3- dimethyl amine -1-oxo-2-propenyl) phenyl] acetamide, with 3-amino-4-cyano pyrazole reaction, forming N-[ 3 - (3-cyano-pyrazolo [1,5-α] pyrimidin-7-yl) phenyl]-N-ethyl acetamide. The synthetic route of the present invention of fewer steps, after treatment is simple, low cost, suitable for industrial production. (by machine translation)

2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS

The present invention relates to compounds of Formula: (I), or pharmaceutically acceptable salt thereof, wherein the variables are defined in the description. The compounds act as kinase inhibitors.