202198-91-2Relevant articles and documents
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease
Sharma, Piyoosh,Tripathi, Avanish,Tripathi, Prabhash Nath,Prajapati, Santosh Kumar,Seth, Ankit,Tripathi, Manish Kumar,Srivastava, Pavan,Tiwari, Vinod,Krishnamurthy, Sairam,Shrivastava, Sushant Kumar
, p. 510 - 524 (2019/02/24)
The multitarget-directed strategy offers an effective and promising paradigm to treat the complex neurodegenerative disorder, such as Alzheimer's disease (AD). Herein, a series of N-benzylpiperidine analogs (17–31 and 32–46) were designed and synthesized
Broadening the chemical scope of laccases: Selective deprotection of N-benzyl groups
Martínez-Montero, Lía,Díaz-Rodríguez, Alba,Gotor, Vicente,Gotor-Fernández, Vicente,Lavandera, Iván
supporting information, p. 2794 - 2798 (2015/05/27)
Laccase from Trametes versicolor together with TEMPO has been found to be a very efficient system to deprotect N-benzylated primary amines, differing from previously described methods since it uses oxygen as a mild oxidant in aqueous medium. Chemoselective removal of the benzyl group was achieved with excellent yields when secondary amines and alcohol moieties were also present.
Efficient and scalable method for the selective alkylation and acylation of secondary amines in the presence of primary amines
Laduron, Frederic,Tamborowski, Vanessa,Moens, Luc,Horvath, Andras,De Smaele, Dirk,Leurs, Stef
, p. 102 - 104 (2012/12/24)
Selective substitution of secondary amines in the presence of primary amines is performed by using the reaction solvent, methyl isobutylketone (MIBK), as a temporary protecting group for the primary amine. After acylation or alkylation of the secondary amine, the resulting imine intermediate is smoothly hydrolysed, leading to the free primary amine in high yield and purity. This procedure represents a cheap and scalable alternative to multistep methods requiring several protections and deprotections.
ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS
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Page 61, (2010/02/10)
Compounds represented by Formula (I) which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R', R
A new series of M3 muscarinic antagonists based on the 4-amino-piperidine scaffold
Diouf,Gadeau,Chelle,Gelbcke,Talaga,Christophe,Gillard,Massingham,Guyaux
, p. 2535 - 2539 (2007/10/03)
A series of 4-amino-piperidine containing molecules have been synthesized and structure-affinity relationship toward the M3-muscarinic receptor has been investigated. Chemical modulations provided molecules with Ki for the human M3-R up to 1 nM with variable selectivity (3- to 40-fold) over the human M2-R. Compounds 2 (pA2=8.3, 8.6) demonstrates in vitro on guinea pig bladder and ileal strips potent anticholinergic properties and tissue selectivity.
