207994-08-9

Basic information

• Product Name: 5-chloro-3-fluoropyridine-2-carboxylic acid
• Synonyms: 5-chloro-3-fluoropyridine-2-carboxylic acid;5-chloro-3-fluoropicolinic acid;5-Chloro-3-fluoropicolinic acid, 2-Carboxy-5-chloro-3-fluoropyridine;2-Pyridinecarboxylic acid, 5-chloro-3-fluoro-;5-Chloro-3-fluoro-2-pyridinecarboxylic acid;5-Chloro-3-fluoro-pyridin-2-carboxylic acid
• CAS NO: 207994-08-9
• Molecular Formula: C₆H₃ClFNO₂
• Molecular Weight: 175.546
• Mol File: 207994-08-9.mol

Chemical Properties

• Boiling Point: 278.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.576±0.06 g/cm3(Predicted)
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: 5-chloro-3-fluoropyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-fluoropyridine-2-carboxylic acid(207994-08-9)
• EPA Substance Registry System: 5-chloro-3-fluoropyridine-2-carboxylic acid(207994-08-9)

Safety Data

• Hazardous Substances Data: 207994-08-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Chloro-3-fluoropyridine-2-carboxylic acid is utilized as an intermediate in the synthesis of various pharmaceuticals. Its presence as a key component in the production process is attributed to its ability to be modified and incorporated into complex molecular structures, contributing to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 5-chloro-3-fluoropyridine-2-carboxylic acid is employed as a precursor in the creation of pesticides and other crop protection agents. Its unique functional groups and substituents allow for the design of compounds with targeted biological activities, enhancing crop yield and protection against pests.
Used in Organic Synthesis:
5-Chloro-3-fluoropyridine-2-carboxylic acid serves as an important building block in organic synthesis, where its versatile structure facilitates a wide range of chemical reactions. The presence of both chlorine and fluorine atoms in its structure imparts unique reactivity, making it suitable for the synthesis of various organic compounds with specific functional groups and properties.
Used in Medicinal Chemistry Research:
Due to its potential biological activities, 5-chloro-3-fluoropyridine-2-carboxylic acid is a subject of interest in medicinal chemistry research. Scientists explore its interactions with biological targets, aiming to uncover new therapeutic applications and understand its mechanisms of action, which could lead to the discovery of novel drugs and treatment strategies.

Upstream product

• 207994-06-7 3-fluoro-5-chloro-2-pyridinecarboxylic acid ethyl ester 
• 89402-43-7 5-chloro-2,3-difluoropyridine 
• 124-38-9 carbon dioxide 
• 514797-98-9 5-chloro-3-fluoro-2-iodopyridine 
• 514797-97-8 2-bromo-5-chloro-3-fluoro-pyridine 
• 514798-05-1 2-bromo-5-chloro-3-fluoro-4-iodopyridine 
• 514798-06-2 5-chloro-3-fluoro-2,4-diiodopyridine 
• 514797-96-7 5-chloro-3-fluoro-2(1H)-pyridinone 

Downstream Products

• 207994-09-0 3-fluoro-5-chloro-2-pyridinecarboxylic acid chloride 
• 1624603-44-6 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-fluoropicolinamide 
• 1624605-33-9 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-cyano-3-fluoropicolinamide 
• 1624605-32-8 N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-fluoropicolinamide 
• 1624605-04-4 N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-cyano-3-fluoropicolinamide 
• 1624606-67-2 N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-fluoropicolinamide 
• 1600507-25-2 N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-6-chloroisoxazolo[4,5-b]pyridin-3-amine 
• 1600511-95-2 N-(5-(5-((6-chloroisoxazolo[4,5-b]pyridin-3-yl)amino)-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 
• 1600535-78-1 (Z)-N-(5-(5-(5-chloro-3-fluoro-N'-hydroxypicolinimidamido)-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 
• 214055-11-5 5-chloro-3-fluoropyridine-2-carbaldehyde 
• 1369542-91-5 (R)-N-{3-[6-amino-4-cyclopropyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl]-4-fluorophenyl}-5-chloro-3-fluoropyridine-2-carboxamide 
• 1352417-54-9 (2S,3R)-N-[3-(5-amino-3-cyclopropyl-2-fluoro-3,6-dihydro-2H-1,4-oxazin-3-yl)phenyl]-5-chloro-3-fluoropyridine-2-carboxamide 
• 1352417-55-0 (2R,3R)-N-[3-(5-amino-3-cyclopropyl-2-fluoro-3,6-dihydro-2H-1,4-oxazin-3-yl)phenyl]-5-chloro-3-fluoropyridine-2-carboxamide 
• 1200498-40-3 methyl 5-chloro-3-fluoropicolinate 

Relevant articles and documents

Creating structural manifolds from a common precursor: Basicity gradient-driven isomerization of halopyridines

5-Chloro-2,3-difluoropyridine, an intermediate in the manufacturing process of an industrial pesticide, can be hydrolyzed to 5-chloro-3-fluoro-2H-pyridinone and the latter converted into 2,5-dichloro-3-fluoropyridine (1a), 2-bromo-5-chloro-3-fluoropyridine (1b), 5-chloro-3-fluoro-2-iodopyridine (1c) and 3-chloro-5-fluoropyridine (1d). Consecutive treatment of these four substrates with lithium diisopropylamide and carbon dioxide or lithium diisopropylamide and iodine affords the corresponding 4-pyridinecarboxylic acids 2 and 4-iodopyridines 3, respectively. Amide-promoted deprotonation of such 4-iodopyridines 3 triggers an isomerization in which lithium and iodine change places. The resulting species can be trapped with carbon dioxide to give the acids 5a-c or neutralized to give the halopyridines 4a-c. The iodopyridines 4a and 4b can be converted into the acids 6a and 6b, the latter product leading also to the congeners 6c and 6d. The diiodopyridine 4c provides an entry to the halopyridine 4d, which at the same time may act as the precursor to the acid 5d, the acid 7 or the bisacid 8. Finally, the acid 9 is accessible from either one of the 5-chloro-3-fluoro-2-halopyridines 1b and 1c. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).