20809-78-3

Basic information

• Product Name: BIS(P-TOLYL)ACETIC ACID
• Synonyms: BIS(P-TOLYL)ACETIC ACID;Bis(4-methylphenyl)acetic acid
• CAS NO: 20809-78-3
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.29704
• Mol File: 20809-78-3.mol

Chemical Properties

• Melting Point: 144 °C
• Boiling Point: 332.1°Cat760mmHg
• Flash Point: 168.8°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 5.96E-05mmHg at 25°C
• Refractive Index: 1.584
• PKA: 4.95±0.10(Predicted)
• CAS DataBase Reference: BIS(P-TOLYL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(P-TOLYL)ACETIC ACID(20809-78-3)
• EPA Substance Registry System: BIS(P-TOLYL)ACETIC ACID(20809-78-3)

Safety Data

• Hazardous Substances Data: 20809-78-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Bis(p-tolyl)acetic acid is used as an intermediate in the synthesis of various drugs, particularly non-steroidal anti-inflammatory medications. Its unique structure allows it to be a key component in the development of these medications, contributing to their efficacy and therapeutic properties.
Used in Agricultural Chemicals Production:
This chemical compound is also used as a building block in the production of agricultural chemicals. Its versatility and reactivity make it an essential component in the synthesis of various agrochemicals, enhancing their effectiveness and performance in agricultural applications.
Used in Dyes and Perfumes Industry:
Bis(p-tolyl)acetic acid is utilized in the production of dyes and perfumes due to its unique chemical properties. It serves as a key component in the synthesis of various dyes, contributing to their color intensity and stability. In the perfume industry, it is used in the creation of various fragrances, enhancing their aroma and longevity.

InChI:InChI=1/C16H16O2/c1-11-3-7-13(8-4-11)15(16(17)18)14-9-5-12(2)6-10-14/h3-10,15H,1-2H3,(H,17,18)

Upstream product

• 40195-52-6 bis(p-tolyl)ketene 
• 4528-66-9 bis(4-methylphenyl)-acetaldehyde 
• 92962-16-8 bis(4-methylphenyl)acetonitrile 
• 411239-48-0 di-p-tolyl-malonic acid diethyl ester 
• 6295-06-3 butyl glyoxalate 
• 20809-68-1 Methyl-2,2-bis--3-oxo-succinat 
• 624-31-7 4-tolyl iodide 
• 86119-84-8 phosphoric acid 
• 1218-89-9 4,4'-dimethylbenzoin 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 57-13-6 urea 
• 110-86-1 pyridine 
• 64-19-7 acetic acid 

Downstream Products

• 5359-40-0 methyl 2,2-di(p-tolyl)acetate 
• 23597-04-8 ethyl 2,2-di(p-tolyl)acetate 
• 528856-88-4 2,2-di-para-toluylethanol 
• 138952-03-1 2,2-bis(4-methylphenyl)-4-pentenoic acid 
• 58539-00-7 2,2-bis(4-methylphenyl)propionic acid 
• 762299-83-2 ISOPROPYL 3-[1-(3-{[BIS(4-METHYLPHENYL)ACETYL]AMINO}PROPYL)-4-PIPERIDINYL]PHENYLCARBAMATE 
• 794479-97-3 N-{3-[1-(3-{[2,2-BIS(4-METHYLPHENYL)ACETYL]AMINO}PROPYL)-4-PIPERIDINYL]PHENYL}CYCLOPROPANECARBOXAMIDE 
• 794480-00-5 N-{3-[1-(3-{[BIS(4-METHYLPHENYL)ACETYL]AMINO}PROPYL)-4-PIPERIDINYL]-4-FLUOROPHENYL}-2-METHYLPROPANAMIDE 
• 762298-48-6 N-{3-[1-(3-{[BIS(4-METHYLPHENYL)ACETYL]AMINO}PROPYL)4-PIPERIDINYL]PHENYL}-2-METHYLPROPANAMIDE 
• 114785-50-1 (S)-1-Benzyl-5-(2,2-di-p-tolyl-acetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid 

Relevant articles and documents

Visible-Light-Driven External-Reductant-Free Cross-Electrophile Couplings of Tetraalkyl Ammonium Salts

Cross-electrophile couplings between two electrophiles are powerful and economic methods to generate C-C bonds in the presence of stoichiometric external reductants. Herein, we report a novel strategy to realize the first external-reductant-free cross-electrophile coupling via visible-light photoredox catalysis. A variety of tetraalkyl ammonium salts, bearing primary, secondary, and tertiary C-N bonds, undergo selective couplings with aldehydes/ketone and CO2. Notably, the in situ generated byproduct, trimethylamine, is efficiently utilized as the electron donor. Moreover, this protocol exhibits mild reaction conditions, low catalyst loading, broad substrate scope, good functional group tolerance, and facile scalability. Mechanistic studies indicate that benzyl radicals and anions might be generated as the key intermediates via photocatalysis, providing a new direction for cross-electrophile couplings.

Silica sulfuric acid as a highly efficient catalyst for the synthesis of diarylacetic acids

ABSTRACT: An efficient heterogeneous method for the synthesis of diarylacetic acids was developed utilizing silica sulfuric acid as a catalyst. The reaction is highly efficient with a small amount of catalyst for the combination of a variety of electron-n

A Study of the Ferrous Ion-initiated SRN1 Reactions of Halogenoarenes with tert-Butyl Acetate and N-Acylmorpholine Enolates

A detailed preparative study is reported of the ferrous ion-initiated SRN1 reactions of a range of halogenoarenes with the sodium enolates of tert-butyl acetate, n-acetylmorpholine and a number of higher N-acylmorpholines.Smooth and rapid substitution occurs in many cases, and good to excellent yields were obtained of arylacetic esters or acids, arylacetamides and arylalkanamides.The broad scope and limitations of the process have been defined, and the possible role of the ferrous ion is discussed.