2082-59-9

Basic information

• Product Name: VALERIC ANHYDRIDE
• Synonyms: VALERIC ANHYDRIDE;Pentanoic acid, anhydride;Pentanoicacid,anhydride;pentanoicacidanhydride;PENTANOIC ANHYDRIDE;N-PENTANOIC ANHYDRIDE;N-VALERIC ANHYDRIDE;VALERIC ANHYDRIDE 98%
• CAS NO: 2082-59-9
• Molecular Formula: C₁₀H₁₈O₃
• Molecular Weight: 186.25
• EINECS: 218-212-9
• Mol File: 2082-59-9.mol

Chemical Properties

• Melting Point: −56 °C(lit.)
• Boiling Point: 228-230 °C(lit.)
• Flash Point: 214 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 0.944 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0758mmHg at 25°C
• Refractive Index: n20/D 1.421(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• BRN: 1770130
• CAS DataBase Reference: VALERIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: VALERIC ANHYDRIDE(2082-59-9)
• EPA Substance Registry System: VALERIC ANHYDRIDE(2082-59-9)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2082-59-9(Hazardous Substances Data)

Usage

Uses

1. Pharmaceutical Industry:
Valeric Anhydride is used as a synthetic reagent for the production of non-imadazole histamine H3-antagonists, which are important in the development of medications targeting histamine-related conditions.
2. Cancer Research:
Valeric anhydride is used as a reactant in the preparation of millepachine derivatives, a new class of tubulin polymerization inhibitors. These compounds have potential applications in cancer research and treatment.
3. Chemical Synthesis:
Valeric anhydride is used as a reactant to synthesize various compounds, including:
a. Alkyl 9-nitrocamptothecin esters through an esterification reaction, which are potentially useful in the development of anticancer drugs.
b. Modified bismuth metal-organic frameworks (Bi-MOFs), which have potential applications in gas storage, catalysis, and drug delivery.
c. O-acylated chitosan nanofibers (CSNFs) for potential usage in biomaterials and food packaging, due to their enhanced properties such as improved mechanical strength and biocompatibility.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C10H18O3/c1-3-5-7-9(11)13-10(12)8-6-4-2/h3-8H2,1-2H3

Upstream product

• 7137-27-1 acetic acid valeric acid-anhydride 
• 108-24-7 acetic anhydride 
• 109-52-4 valeric acid 
• 75-36-5 acetyl chloride 
• 79-37-8 oxalyl dichloride 
• 6106-41-8 sodium valerate 
• 71-43-2 benzene 
• 109-72-8 n-butyllithium 
• 86950-96-1 1-(methoxycarbonyl)pyridine-1-ium chloride 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 7732-18-5 water 
• 7553-56-2 iodine 
• 56-23-5 tetrachloromethane 
• 1942-46-7 5-decyne 

Downstream Products

• 3194-17-0 1-furan-2-yl-pentan-1-one 
• 725266-67-1 6-ethyl-3-valeryl-pyran-2,4-dione 
• 551-08-6 3-butylidenephthalide 
• 67049-60-9 2,4,6-triiodo-3,5-bis-valerylamino-benzoic acid 
• 5394-88-7 1-(4-methoxy-3-methylphenyl)-1-pentanone 
• 63042-28-4 estradiol divalerate 
• 128788-26-1 3-valeryloxy-estra-1,3,5(10)-trien-17-one 
• 3129-43-9 testosterone-17-valerate 
• 7726-03-6 cholesteryl n-pentanoate 
• 65201-68-5 benzene-hexa-n-pentanoate 
• 6677-15-2 17-valeryloxy-pregn-4-ene-3,20-dione 
• 2706-90-3 Perfluoropentanoic acid 
• 53086-30-9 3c-(3-nitro-phenyl)-2-propyl-acrylic acid 
• 53086-30-9 α-propyl-m-nitrocinnamic acid 

Relevant articles and documents

ON THE REGIOSELECTIVITY OF THE REACTION OF N-METHOXYCARBONYLPYRIDINIUM CHLORIDE WITH GRIGNARD REAGENTS: HIGHLY REGIOSELECTIVE SYNTHESIS OF 2-SUBSTITUTED N-METHOXYCARBONYL-1,2-DIHYDROPYRIDINES.

Whereas alkyl Grignard reagents undergo 1,2- and 1,4-additions to N-methoxycarbonyl-pyridinium chloride in a variable ratio, alkenyl and alkynyl Grignard reagents do the exclusive 1,2-addition to afford 2-substituted N-methoxycarbonyl-1,2-dihydropyridines in fair to excellent yields.

PROCESSES FOR PREPARING 4-METHYL-5-NONANONE AND 4-METHYL-5-NONANOL

The present invention provides a process for preparing 4-methyl-5-nonanone of the following formula (3), the process comprising at least a step of subjecting pentanoic anhydride of the following formula (1) and a 2-pentyl nucleophilic reagent of the following general formula (2), in which M represents Li, MgZ1, or ZnZ1, wherein Z1 represents a halogen atom or a 2-pentyl group, to a nucleophilic substitution reaction to produce 4-methyl-5-nonanone (3), as well as a process for preparing 4-methyl-5-nonanol of the following formula (7), the process comprising at least steps of preparing 4-methyl-5-nonanone and subjecting the obtained 4-methyl-5-nonanone and a reducing agent to a reduction reaction to produce 4-methyl-5-nonanol (7).

Valeric anhydride preparation method

The present invention discloses a valeric anhydride preparation method comprising the following steps: (a) adding an organic solvent and valeric acid into a reaction vessel, then adding portionwise dicyclohexyl carbodiimide for reaction at the room temperature for 20 to 40 minutes; and (2) removing solid impurities by filtration, recovering the organic solvent by distillation under reduced pressure, after the the organic solvent is completely recovered, heating for distilling under reduced pressure to obtain an object product valeric anhydride. The method uses the valeric acid and the dicyclohexyl carbodiimide for reaction for preparation of the valeric anhydride, the separation process is simple, the obtained valeric anhydride is high in quality, and the valeric anhydride purity reaches 99.3%.

Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors

The natural product, cyclophellitol and its aziridine analogue are potent mechanism-based retaining β-glucosidase inhibitors. In this paper we explore the inhibitory potency of a number of cyclophellitol analogues against the three human retaining β-glucosidases, GBA, GBA2 and GBA3. We demonstrate that N-alkyl cyclophellitol aziridine is at least equally potent in inhibiting the enzymes evaluated as its N-acyl congener, whereas the N-sulfonyl analogue is a considerably weaker inhibitor. Our results complement the literature on the inhibitory potency of cyclophellitol analogues and hold promise for the future design of more effective activity-based retaining glycosidase probes with respect to probe stability in physiological media.

Synthesis of α-diazoketone by the action of diazoalkanes on butyric anhydride

Butyric anhydride reacts with diazo-n-alkanes In dry ether at 0°C gave 1-diazo-1-n-alkyl pentanones.

Kinetics of alcoholysis of valeric anhydride by cyclohexanol in the presence of formic acid

Kinetics of the reaction proceeding at the industrial process of cyclohexane oxidation are studied by the model reaction of the alcoholysis of valeric anhydride by cyclohexanol in the presence of formic acid.

Simple preparation of symmetrical carboxylic acid anhydrides by means of Na2CO3/SOCl2

A convenient and general method for the synthesis of symmetrical carboxylic acid anhydrides using sodium carbonate/thionyl chloride is described. Copyright Taylor & Francis Group, LLC.

Indole derivative and application thereof

This invention relates to a compound represented by formula (I) or a salt thereof, and a therapeutic agent for osteoporosis, an osteoblast activator, and an osteoclast suppressor comprising the same: wherein X represents a halogen atom; R1 represents a hydrogen atom, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, a substituted or unsubstituted aromatic group, substituted or unsubstituted aralkyl, substituted or unsubstituted acyl, substituted or unsubstituted arylsulfonyl, substituted or unsubstituted C1-6 alkylsulfonyl, or hydroxyl; R2 represents substituted or unsubstituted C1-21 alkyl; R3, R5 and R6, which may be the same or different, each represent a hydrogen atom or a halogen atom; and R4 represents a hydrogen atom or substituted or unsubstituted C1-6 alkyl.

Dabco/SOCl2, mild, and convenient reagent for the preparation of symmetrical carboxylic acid anhydrides

Various types of carboxylic acids undergo rapid dehydration with 1,4-diazabicyclo[2.2.2]octane, dabco / thionyl chloride, under mild reaction conditions to afford symmetrical acid anhydrides in high isolated yields.

A search for quantitative acylation of α-trinositol (1D-myo-inositol 1,2,6-tris(dihydrogen phosphate) pentasodium salt)

The acylation of α-trinositol is very sensitive to reaction conditions. Competing condensation reactions may give pyrophosphates and cyclic phosphates. Treatment of a tert-ammonium salt corresponding to α-trinositol with carboxylic acid anhydride and DMAP gives a good yield of the expected esters.