213699-53-7

Basic information

• Product Name: 1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethyl-
• Synonyms: 1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethyl-
• CAS NO: 213699-53-7
• Molecular Formula: C₁₅H₁₇NO₆
• Molecular Weight: 307.29858
• Mol File: 213699-53-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethyl-(213699-53-7)
• EPA Substance Registry System: 1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethyl-(213699-53-7)

Safety Data

• Hazardous Substances Data: 213699-53-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethylis used as a research compound for its potential medicinal properties. The presence of the diMethoxyphenyl group may contribute to its biological activity, making it a promising candidate for the development of new medications.
Used in Organic Synthesis:
1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethylis used as an intermediate in the production of other chemicals. Its unique structure and functional groups make it a valuable component in the synthesis of various organic compounds.
Used in Medicinal Chemistry:
1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethylis used as a building block in the design and synthesis of novel pharmaceutical agents. Its structural features and potential biological activities can be leveraged to create new drugs with improved therapeutic effects.
Used in Chemical Intermediates Industry:
1,3-Dioxane-4,6-dione, 5-[[(3,4-diMethoxyphenyl)aMino]Methylene]-2,2-diMethylis used as a key intermediate in the synthesis of various chemical products. Its versatility and reactivity make it an essential component in the production of a wide range of compounds for different industries.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 6315-89-5 3,4-dimethoxyaniline 
• 149-73-5 trimethyl orthoformate 
• 122-51-0 orthoformic acid triethyl ester 
• 15568-85-1 5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 127285-54-5 1,4-dihydro-6,7-dimethoxy-4-oxoquinoline 
• 13425-93-9 6,7-dimethoxyquinoline-4-ol 
• 190728-24-6 6,7?dimethoxy?4?(4?nitrophenoxy)quinoline 
• 190728-25-7 4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline 
• 286371-44-6 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-chloroaniline 
• 1437323-99-3 4-(6,7-dimethoxyquinolin-4-yloxy)-2,3-difluorophenylamine 
• 347161-74-4 4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline 
• 516526-44-6 4-(2-fluoro-4-nitro-phenoxy)-6,7-dimethoxy-quinoline 
• 35654-56-9 6,7-dimethoxy-4-chloroquinoline 
• 848128-82-5 5,6-dimethoxy-quinolin-4-ol 

Relevant articles and documents

N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound

The invention belongs to the technical field of medicines, relates to a compound with antitumor activity and a specific chemical structure, and in particular relates to an N-((6, 7-dimethoxyquinoline-4-yl) oxy) methyl)-N-(5-phenyl-1, 3, 4-thiadiazole-2-yl) benzamide compound and a preparation method and an application thereof. The structural general formula of the compound is shown in the specification, wherein an R group is mono-substituted or double-substituted phenyl, fluorophenyl, chlorphenyl, bromophenyl, benzyl, benzyloxy, benzene nitro or trifluoromethyl substituted at 2-position, 3-position or 4-position. Pharmacological studies show that the compound provided by the invention has a relatively remarkable proliferation inhibition effect on HER-2 positive breast cancer cells SK-Br-3, the effect is obviously superior to that of HER-2 negative breast cancer cells MCF-7, the compound can be used for preparing antitumor drugs, and a new way is opened up for deep research and development of tumor drugs in the future. The preparation method provided by the invention is simple and feasible, relatively high in yield and easy for large-scale production.

AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE

The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

AMINO ESTER DERIVATIVES, SAILTS THEREOF AND METHODS OF USE

The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.