214210-30-7

Basic information

• Product Name: 4-Bromo-2-fluorobenzenesulfonamide
• Synonyms: 4-Bromo-2-fluorobenzenesulfonamide;4-broMo-2-fluorobenzene-1-sulfonaMide
• CAS NO: 214210-30-7
• Molecular Formula: C₆H₅BrFNO₂S
• Molecular Weight: 254.08
• Product Categories: Fluorobenzene;Benzenes;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 214210-30-7.mol

Chemical Properties

• Boiling Point: 356.086 °C at 760 mmHg
• Flash Point: 169.155 °C
• Appearance: /
• Density: 1.831 g/cm³
• Vapor Pressure: 0.038mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.50±0.60(Predicted)
• CAS DataBase Reference: 4-Bromo-2-fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-fluorobenzenesulfonamide(214210-30-7)
• EPA Substance Registry System: 4-Bromo-2-fluorobenzenesulfonamide(214210-30-7)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 214210-30-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-Bromo-2-fluorobenzenesulfonamide is utilized as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable component in the development of new drugs and pesticides.
Used in Chemical Research and Development:
In the chemical industry, 4-Bromo-2-fluorobenzenesulfonamide serves as a key intermediate in research and development processes. Its properties and reactivity are studied to understand its potential applications and to develop new methods for synthesizing related compounds.
Used in Antimicrobial Applications:
4-Bromo-2-fluorobenzenesulfonamide has been studied for its potential antimicrobial properties. It is used as a subject of interest in the development of new therapeutic agents that can combat various types of infections.
Used in Anti-inflammatory Applications:
4-Bromo-2-fluorobenzenesulfonamide has also been investigated for its anti-inflammatory properties, which could be beneficial in the development of new treatments for inflammatory conditions and diseases.

InChI:InChI=1/C9H8ClFO2/c1-13-9(12)4-6-2-3-7(11)5-8(6)10/h2-3,5H,4H2,1H3

Upstream product

• 216159-03-4 4-bromo-2-fluorobenzenesulfonyl chloride 

Downstream Products

• 855481-98-0 4-bromo-2-(cyclohexyloxy)benzenesulfonamide 
• 1204573-63-6 4-bromo-2-(cyclopropylamino)benzenesulfonamide 
• 491876-03-0 C₂₇H₂₅BFNO₆S 
• 30058-40-3 2-fluorobenzenesulfonamide 
• 491876-10-9 4-bromo-N-(4,4'-dimethoxytrityl)-2-fluorobenzenesulfonamide 

Relevant articles and documents

PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.

HIGHLY SELECTIVE C-MET INHIBITORS AS ANTICANCER AGENTS

Disclosed are novel nitrogen-containing, heterocyclic, c-Met inhibitor compounds, processes for their preparation and formulations thereof. The compounds are useful as therapeutical agents for the inhibition, regulation, and control of c-Met kinase signal pathway, and useful for treating in a subject a cell proliferative disorder or disorders mediated by c-Met.

AMINOALCOHOL DERIVATIVES

The present invention relates to a compound of the formula [I]: wherein (a), in which -Y-, R4, R5 and R6 are4 R5each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20 R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, -Z-R9 or (b), in which -Z- is -0-, -S-, R9 -SO- or -SO2-, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R10, in which -D- is -CONHSO2- or -S02NHCO-, E is bond or lower alkylene, and R10is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.

Aminoalcohol derivatives

The present invention relates to a compound formula[I]: wherein X is bond, —CH2—, —O— or —NH—, R1 and R12 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or optionally substituted lower alkyl, R3 is hydrogen or an amino protective group, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, R7 is -Z-R13, in which Z is bond, etc., and R13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, R8 is —Y—R9, in which Y is bond, —CH2—, —O—, —S—, etc., and R9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.