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3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxyis a chemical compound with the potential for various applications, particularly in the pharmaceutical industry. It is characterized by its unique molecular structure, which includes a quinoline ring with a carbonitrile group, a chloropropoxy group, and hydroxy and methoxy substituents. 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxyis known for its role in the synthesis of important medications.

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  • 214470-66-3 Structure
  • Basic information

    1. Product Name: 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-
    2. Synonyms: 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-;7-(3-chloropropoxy)-4-hydroxy-6-methoxyquinoline-3-carbonitrile;7-(3-Chloropropoxy)-4-hydroxy-6-methoxy-3-quinolinecarbonitrile
    3. CAS NO:214470-66-3
    4. Molecular Formula: C14H13ClN2O3
    5. Molecular Weight: 292.71762
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 214470-66-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 506.4°C at 760 mmHg
    3. Flash Point: 260.1°C
    4. Appearance: /
    5. Density: 1.37g/cm3
    6. Vapor Pressure: 7.04E-11mmHg at 25°C
    7. Refractive Index: 1.623
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 1.02±0.50(Predicted)
    11. CAS DataBase Reference: 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-(214470-66-3)
    13. EPA Substance Registry System: 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-(214470-66-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 214470-66-3(Hazardous Substances Data)

214470-66-3 Usage

Uses

Used in Pharmaceutical Industry:
3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxyis used as a key intermediate in the synthesis of Bosutinib (B676095), an anticancer medication. The compound plays a crucial role in the development of this drug, which targets specific tyrosine kinases involved in cancer cell growth and proliferation.
Application Reason:
The compound's unique structure allows it to be a valuable building block in the synthesis of Bosutinib, a potent inhibitor of BCR-ABL and Src kinases. By incorporating this compound into the drug's structure, researchers can develop a medication that effectively targets cancer cells and helps in the treatment of various types of cancer.

Check Digit Verification of cas no

The CAS Registry Mumber 214470-66-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,4,7 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 214470-66:
(8*2)+(7*1)+(6*4)+(5*4)+(4*7)+(3*0)+(2*6)+(1*6)=113
113 % 10 = 3
So 214470-66-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H13ClN2O3/c1-19-12-5-10-11(6-13(12)20-4-2-3-15)17-8-9(7-16)14(10)18/h5-6,8H,2-4H2,1H3,(H,17,18)

214470-66-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-(3-Chloropropoxy)-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarbon itrile

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:214470-66-3 SDS

214470-66-3Relevant articles and documents

A new and practical synthesis of 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile

Mao, Yongjun,Qin, Jianfeng,He, Haijun,Liu, Gang,Gao, Bingyi,Wang, Han

, p. 1885 - 1891 (2014/08/18)

New and improved synthetic route of bosutinib intermediate 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile (3) is described on a hectogram scale. An intramolecular cyclization of 3-(2-aminophenyl)-3-oxopropanenitrile 11 with DMF-DM

Synthesis and structure-activity relationships of 3-cyano-4(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors

Zhang, Nan,Wu, Biqi,Powell, Dennis,Wissner, Allan,B. Floyd, Middleton,D. Kovacs, Eleonora,Toral-Barza, Lourdes,Kohler, Constance

, p. 2825 - 2828 (2007/10/03)

A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells. (C) 2000 Elsevier Science Ltd.

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