214470-66-3 Usage
Uses
Used in Pharmaceutical Industry:
3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxyis used as a key intermediate in the synthesis of Bosutinib (B676095), an anticancer medication. The compound plays a crucial role in the development of this drug, which targets specific tyrosine kinases involved in cancer cell growth and proliferation.
Application Reason:
The compound's unique structure allows it to be a valuable building block in the synthesis of Bosutinib, a potent inhibitor of BCR-ABL and Src kinases. By incorporating this compound into the drug's structure, researchers can develop a medication that effectively targets cancer cells and helps in the treatment of various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 214470-66-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,4,7 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 214470-66:
(8*2)+(7*1)+(6*4)+(5*4)+(4*7)+(3*0)+(2*6)+(1*6)=113
113 % 10 = 3
So 214470-66-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H13ClN2O3/c1-19-12-5-10-11(6-13(12)20-4-2-3-15)17-8-9(7-16)14(10)18/h5-6,8H,2-4H2,1H3,(H,17,18)
214470-66-3Relevant articles and documents
A new and practical synthesis of 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile
Mao, Yongjun,Qin, Jianfeng,He, Haijun,Liu, Gang,Gao, Bingyi,Wang, Han
, p. 1885 - 1891 (2014/08/18)
New and improved synthetic route of bosutinib intermediate 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile (3) is described on a hectogram scale. An intramolecular cyclization of 3-(2-aminophenyl)-3-oxopropanenitrile 11 with DMF-DM
Synthesis and structure-activity relationships of 3-cyano-4(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors
Zhang, Nan,Wu, Biqi,Powell, Dennis,Wissner, Allan,B. Floyd, Middleton,D. Kovacs, Eleonora,Toral-Barza, Lourdes,Kohler, Constance
, p. 2825 - 2828 (2007/10/03)
A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells. (C) 2000 Elsevier Science Ltd.