215257-64-0

Basic information

• Product Name: 2-Pyrimidinamine, 4,6-bis(4-chlorophenyl)-
• CAS NO: 215257-64-0
• Molecular Formula: C16H11Cl2N3
• Molecular Weight: 316.189
• Mol File: 215257-64-0.mol

Chemical Properties

• CAS DataBase Reference: 2-Pyrimidinamine, 4,6-bis(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 4,6-bis(4-chlorophenyl)-(215257-64-0)
• EPA Substance Registry System: 2-Pyrimidinamine, 4,6-bis(4-chlorophenyl)-(215257-64-0)

Safety Data

• Hazardous Substances Data: 215257-64-0(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 20725-25-1 1,3-bis(4-chlorophenyl)prop-2-en-1-one 
• 113-00-8 guanidine nitrate 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 873-76-7 para-Chlorobenzyl alcohol 
• 19672-59-4 (E)-1,3-di(4-chlorophenyl)-2-propen-1-one 
• 50-01-1 guanidine hydrochloride 
• 506-93-4 guanidine nitrate 
• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 1679-18-1 4-Chlorophenylboronic acid 
• 593-85-1 diguanidine carbonate 

Downstream Products

• 1392402-46-8 C₂₃H₁₆Cl₂N₄ 
• 1392402-47-9 C₂₉H₂₀Cl₂N₆O 
• 1392402-48-0 C₂₈H₁₉Cl₂N₇O 

Relevant articles and documents

A green approach for the synthesis of benzazolyl pyrimidinyl carbamothioates under ultrasonication and their antimicrobial activity

A library of benzazolyl pyrimidinyl carbamothioates were prepared by the reaction of benzazolyl carbonothioates with pyrimidinyl-2-amine in the presence of an ionic liquid- 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) under ultrasonication at a frequency of 35?kHz and tested for antimicrobial activity. Chloro- and nitro-substituted benzothiazolyl/benzimidazolyl pyrimidinyl carbamothioates displayed prominent antibacterial activity against Bacillus subtilis, while nitro-substituted benzothiazolyl/benzimidazolyl pyrimidinyl carbamothioates showed excellent antifungal activity against Aspergilus niger. Graphic abstract: [Figure not available: see fulltext.].

Photocatalytic synthesis of 2-amino-4,6-diarylpyrimidines using nanoTiO2

Photocatalytic synthesis of 2-amino-4,6-diarylpyrimidines was carried out by using nano TiO2. The method follows a green route by avoiding the use of toxic organic solvents and tedious experimental conditions. Compared with conventional methods the present strategy offers excellent yield under UV irradiation for a period of 20 min in ethanolic medium. Only a small quantity of nanocatalyst (1 mol%) is sufficient to achieve the completion of the reaction. The nanocatalyst can be reused up to four reaction cycles without much loss in the activity.

Iron Catalyzed Synthesis of Pyrimidines Under Air

Herein we report an iron-catalyzed multicomponent dehydrogenative functionalization of alcohols to pyrimidines under atmospheric conditions. Using a well-defined Fe(II)-complex featuring redox noninnocent 2-phenylazo-(1,10-phenanthroline) ligand, as a cat

Ultrasound-mediated synthesis, biological evaluation, docking and in vivo acute oral toxicity study of novel indolin-2-one coupled pyrimidine derivatives

The work reports ultrasound-mediated greener synthesis of 11 novel 3-(4-(4-chlorophenyl)-6-(substituted phenyl/heteryl)pyrimidin-2-ylimino)indolin-2-one (7a–7k) derivatives. The synthesized derivatives were evaluated for their in vitro anticancer activity against a panel of selected human cancer cell lines of breast (MCF-7), cervix (HeLa), prostate (PC-3) and lung (A-549). Among the tested compounds, 7b exhibited most promising in vitro anticancer activity against HeLa, PC-3 and A-549 with GI50 value 15.38, 19.67 and 4.37?μM, respectively. The compounds (7a–7k) were also screened for induction of apoptosis and morphological changes in cancer cells at their GI50 concentration. The treatment of HeLa, PC-3 and A549 cancer cells with 7b and treatment of MCF-7 cancer cells with 7h showed apoptosis and morphological changes such as cell shrinkage, cell wall deformation and reduced number of viable cells. The compound 7b has shown almost 5.00 times more selectivity for PC-3 cancer cell lines in comparison to the RWPE-1 normal prostate epithelial cells. Molecular docking study has been carried out, which replicates results of biological activity in cases of initial hits 7b, 7c and 7d, suggesting that these compounds have a potential to become lead molecules in the drug discovery process. In silico ADMET study was performed for predicting pharmacokinetic properties and toxicity profile of the synthesized compounds and expressed good oral drug-like behaviour. An in vivo acute oral toxicity study was performed using Swiss albino mice for the most active compounds 7b and 7c, and results indicate that the compounds are non-toxic in nature.

Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity

(1) The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. (2) Better yields were recorded in 4-(N,N-dimethylamino)pyridine and Et3N. (3) The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity (13c, 13e, 14e: minimum inhibitory concentration?=?6.25?μg/well against Bacillus subtilis; 13e, 14e: minimum inhibitory concentration?=?6.25?μg/well against Aspergillus niger).

Synthesis and Antimicrobial Activity of Azolyl Pyrimidines

A new class of azolyl pyrimidines linked by diamino sulfone moiety was prepared and studied their antimicrobial activity. Chloro-substituted and nitro-substituted thiazolyl pyrimidines (9c and 9e) showed excellent antibacterial activity against Bacillus subtilis, while imidazolyl pyrimidines (10c and 10e) exhibited promising antifungal activity against Aspergillus niger.

Synthesis, characterization of 4,6-disubstituted aminopyrimidines and their sulphonamide derivatives as anti-Amoebic agents

The present study describes the synthesis and anti-Amoebic activity of 4,6-disubstituted aminopyrimidines (1b-10b) and their sulphonamide derivatives (1-20). All the desired compounds were characterized by spectral data and their purity was confirmed by e

Synthesis and evaluation of some novel [1,2,4]triazolo[1,5-α] pyrimidine derivatives for anticancer activity

A series of 7-(4-chlorophenyl)-2-phenyl-1,7-dihydro [1,2,4] triazolo [1,5α] pyrimidine 4a-l have been synthesized and evaluated for anticancer activity. The newly synthesized compounds have been characterized by IR, 1H NMR and elemental analyse

Synthesis of 2-amino-4,6-diarylpyrimidines using inorganic solid support under microwave and ultrasound irradiation and their antibacterial activity

An expeditious method for the exclusive one-pot synthesis of 2-amino-4,6-diarylpyrimidines (3a-i) is described by the condensation of variously substituted chalcones (1a-i) with guanidine nitrate using inorganic solid support under microwave or ultrasound

Anti-bacterial and anti-leishmanial studies of 4, 6-diarylpyrimidin-2- amines

Seven new chalcones along with nine already reported ones were synthesized from aryl aldehydes and substituted acetophenones by Claisen-Schmidt condensation. Each chalcone was treated with guanidine hydrochloride followed by oxidation with H2O