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Oxazole,2-(chloromethyl)-5-(1,1-dimethylethyl)-, with the chemical abstracts service (CAS) registry number 77055-51-9, is a chemical compound belonging to the Oxazole family. It is typically a liquid at room temperature and is characterized by its unique molecular structure, which includes an oxazole ring (a heterocyclic compound) with a tertiary butyl group and a chloromethyl group substituted at the 5 and 2 positions, respectively.

224441-73-0

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224441-73-0 Usage

Uses

Used in Pharmaceutical Industry:
Oxazole,2-(chloromethyl)-5-(1,1-dimethylethyl)is used as an intermediate compound for the synthesis of various pharmaceuticals. Its distinctive molecular structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicine.
Used in Agrochemical Industry:
Oxazole,2-(chloromethyl)-5-(1,1-dimethylethyl)is also utilized as a building block in the creation of agrochemicals. Its presence in the molecular structure of certain agrochemicals can enhance their effectiveness in pest control and crop protection, thereby supporting agricultural productivity.
Used in Dye Industry:
Oxazole,2-(chloromethyl)-5-(1,1-dimethylethyl)is employed as a chemical constituent in the formulation of dyes. Its incorporation into dye molecules can improve the colorfastness and stability of the dyes, making them more suitable for various applications in the textile and other industries.

Check Digit Verification of cas no

The CAS Registry Mumber 224441-73-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,4,4,4 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 224441-73:
(8*2)+(7*2)+(6*4)+(5*4)+(4*4)+(3*1)+(2*7)+(1*3)=110
110 % 10 = 0
So 224441-73-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H12ClNO/c1-8(2,3)6-5-10-7(4-9)11-6/h5H,4H2,1-3H3

224441-73-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-tert-butyl-2-(chloromethyl)-1,3-oxazole

1.2 Other means of identification

Product number -
Other names 5-t-butyl-2-chloromethyloxazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:224441-73-0 SDS

224441-73-0Downstream Products

224441-73-0Relevant articles and documents

Nitrogen Mustard Derivatives

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, (2014/10/16)

The disclosure includes compounds of Formula (1): wherein X1, X2, Q, Z, R1, and R2 are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.

CDK INHIBITORS

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Page/Page column 51-52, (2010/07/09)

The present invention relates to CDK inhibitors and their use in the treatment of cell proliferative diseases such as cancer.

CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY

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, (2009/04/25)

The present invention relates to CDK inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The compounds of the invention may further act as HDAC inhibitors.

N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl] -4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent

Misra, Raj N.,Xiao, Hai-Yun,Kim, Kyoung S.,Lu, Songfeng,Han, Wen-Ching,Barbosa, Stephanie A.,Hunt, John T.,Rawlins, David B.,Shan, Weifang,Ahmed, Syed Z.,Qian, Ligang,Chen, Bang-Chi,Zhao, Rulin,Bednarz, Mark S.,Kellar, Kristen A.,Mulheron, Janet G.,Batorsky, Roberta,Roongta, Urvashi,Kamath, Amrita,Marathe, Punit,Ranadive, Sunanda A.,Sack, John S.,Tokarski, John S.,Pavletich, Nikola P.,Lee, Francis Y. F.,Webster, Kevin R.,Kimball, S. David

, p. 1719 - 1728 (2007/10/03)

N-Acyl-2-aminothiazoles with nonaromatic acyl side chains containing a basic amine were found to be potent, selective inhibitors of CDK2/cycE which exhibit antitumor activity in mice. In particular, compound 21 {N-[5-[[[5-(1,1-dimethylethyl)-2- oxazolyl]m

N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

-

, (2008/06/13)

The present invention describes compounds of formula I: and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula I compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for exam

Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy

-

, (2008/06/13)

The invention provides a method for preventing or treating alopecia induced by chemotherapy or radiotherapy by administering to a mammalian specie in need thereof a therapeutically effective amount of a compound of formula I or II or a pharmaceutically ac

Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: Synthesis, x-ray crystallographic analysis, and biological activities

Kim, Kyoung Soon,Kimball, S. David,Misra, Raj N.,Rawlins, David B.,Hunt, John T.,Xiao, Hai-Yun,Lu, Songfeng,Qian, Ligang,Han, Wen-Ching,Shan, Weifang,Mitt, Toomas,Cai, Zhen-Wei,Poss, Michael A.,Zhu, Hong,Sack, John S.,Tokarski, John S.,Chang, Chieh Ying,Pavletich, Nikola,Kamath, Amrita,Humphreys, William G.,Marathe, Punit,Bursuker, Isia,Kellar, Kristen A.,Roongta, Urvashi,Batorsky, Roberta,Mulheron, Janet G.,Bol, David,Fairchild, Craig R.,Lee, Francis Y.,Webster, Kevin R.

, p. 3905 - 3927 (2007/10/03)

High throughput screening identified 2-acetamido-thiazolylthio acetic ester 1 as an inhibitor of cyclin-dependent kinase 2 (CDK2). Because this compound is inactive in cells and unstable in plasma, we have stabilized it to metabolic hydrolysis by replacing the ester moiety with a 5-ethyl-substituted oxazole as in compound 14. Combinatorial and parallel synthesis provided a rapid analysis of the structure-activity relationship (SAR) for these inhibitors of CDK2, and over 100 analogues with IC50 values in the 1-10 nM range were rapidly prepared. The X-ray crystallographic data of the inhibitors bound to the active site of CDK2 protein provided insight into the binding modes of these inhibitors, and the SAR of this series of analogues was rationalized. Many of these analogues displayed potent and broad spectrum antiproliferative activity across a panel of tumor cell lines in vitro. In addition, A2780 ovarian carcinoma cells undergo rapid apoptosis following exposure to CDK2 inhibitors of this class. Mechanism of action studies have confirmed that the phosphorylation of CDK2 substrates such as RB, histone H1, and DNA polymerase α (p70 subunit) is reduced in the presence of compound 14. Further optimization led to compounds such as water soluble 45, which possesses a favorable pharmacokinetic profile in mice and demonstrates significant antitumor activity in vivo in several murine and human models, including an engineered murine mammary tumor that overexpresses cyclin E, the coactivator of CDK2.

Methods for preventing and treating alopecia induced by chemotherapy or radiotherapy

-

, (2008/06/13)

The invention provides a method for preventing or treating alopecia induced by chemotherapy or radiotherapy by administering to a mammalian specie in need thereof a therapeutically effective amount of a compound of formula I or II or a pharmaceutically ac

N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

-

, (2008/06/13)

The present invention describes compounds of formula I and enantiomers, diastereomers and pharmaceutically acceptable salts thereof. The formula I compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for examp

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