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4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline is a quinazoline derivative with potential pharmacological properties. It is a chemical compound that has been studied for its potential use in treating various diseases, including cancer and inflammatory conditions. 4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline exhibits inhibitory effects on specific enzymes and receptors in the body, making it a valuable candidate for drug development. Its unique structure and properties also make it a promising candidate for further research and potential therapeutic applications.

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  • Quinazoline,4-chloro-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-

    Cas No: 264208-72-2

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  • 264208-72-2 Structure
  • Basic information

    1. Product Name: 4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline
    2. Synonyms: 4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;4-Chloro-7-[N-methylpiperidin-4-ylmethoxy]-6-methoxyquinazoline;4-Chloro-6-Methoxy-7-(4-Methyl-piperidin-1-ylMethoxy)-quinazoline;7-((1-Methylpiperidin-4-yl)Methoxy)-4-chloro-6-Methoxyquinazoline;4-chloro-6-Methoxy-7-[(1-Methyl-4-piperidinyl)Methoxy]-Quinazoline;Quinazoline,4-chloro-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
    3. CAS NO:264208-72-2
    4. Molecular Formula: C16H20ClN3O2
    5. Molecular Weight: 321.806
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 264208-72-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 446.5±40.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.221
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. PKA: 8.90±0.10(Predicted)
    10. CAS DataBase Reference: 4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline(264208-72-2)
    12. EPA Substance Registry System: 4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline(264208-72-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 264208-72-2(Hazardous Substances Data)

264208-72-2 Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline is used as a potential therapeutic agent for the treatment of various diseases, such as cancer and inflammatory conditions. Its inhibitory effects on certain enzymes and receptors make it a valuable candidate for drug development.
Used in Drug Development:
4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline is used as a candidate for the development of new drugs targeting specific enzymes and receptors involved in the pathogenesis of various diseases. Its unique structure and properties contribute to its potential as a promising therapeutic agent.
Used in Research:
4-Chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline is used as a subject of research to further explore its pharmacological properties and potential therapeutic applications. Its unique structure and properties make it an interesting candidate for studying the mechanisms of action and potential synergistic effects with other compounds in the treatment of various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 264208-72-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,4,2,0 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 264208-72:
(8*2)+(7*6)+(6*4)+(5*2)+(4*0)+(3*8)+(2*7)+(1*2)=132
132 % 10 = 2
So 264208-72-2 is a valid CAS Registry Number.

264208-72-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-chloro-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:264208-72-2 SDS

264208-72-2Relevant articles and documents

QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF

-

, (2021/02/18)

Related to a quinazoline compound serving as an EFGR triple mutation inhibitor and applications thereof. Specifically, disclosed are a compound as represented by the following formula (I), a pharmaceutical composition comprising the compound of formula (I

Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S

Li, Qiannan,Zhang, Tao,Li, Shiliang,Tong, Linjiang,Li, Junyu,Su, Zhicheng,Feng, Fang,Sun, Deheng,Tong, Yi,Wang, Xia,Zhao, Zhenjiang,Zhu, Lili,Ding, Jian,Li, Honglin,Xie, Hua,Xu, Yufang

, p. 869 - 873 (2019/06/08)

In this paper, we describe the discovery and optimization of a series of noncovalent reversible epidermal growth factor receptor inhibitors of EGFRL858R/T790M/C797S. One of the most promising compounds, 25g, inhibited the enzymatic activity of EGFRL858R/T790M/C797S with an IC50 value of 2.2 nM. Cell proliferation assays showed that 25g effectively and selectively inhibited the growth of EGFRL858R/T790M/C797S-dependent cells. This series of compounds, which occupy both the ATP binding site and the allosteric site of the EGFR kinase, may serve as a basis for the development of fourth-generation EGFR inhibitors for L858R/T790M/C797S mutants.

Anilinoquinazoline inhibitors of the RET kinase domain - Elaboration of the 7-position

Jordan, Allan M.,Begum, Habiba,Fairweather, Emma,Fritzl, Samantha,Goldberg, Kristin,Hopkins, Gemma V.,Hamilton, Niall M.,Lyons, Amanda J.,March, H. Nikki,Newton, Rebecca,Small, Helen F.,Vishwanath, Swamy,Waddell, Ian D.,Waszkowycz, Bohdan,Watson, Amanda J.,Ogilvie, Donald J.

, p. 2724 - 2729 (2016/05/09)

We have previously reported a series of anilinoquinazoline derivatives as potent and selective biochemical inhibitors of the RET kinase domain. However, these derivatives displayed diminished cellular potency. Herein we describe further optimisation of the series through modification of their physicochemical properties, delivering improvements in cell potency. However, whilst cellular selectivity against key targets could be maintained, combining cell potency and acceptable pharmacokinetics proved challenging.

Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase

Yu, Bing,Tang, Li-Da,Li, Yi-Liang,Song, Shu-Hui,Ji, Xiao-Liang,Lin, Mu-Sen,Wu, Chun-Fu

scheme or table, p. 110 - 114 (2012/02/16)

We report herein the design and synthesis of novel 4-aminoquinazoline derivatives based on the inhibitors of VEGFR-2 tyrosine kinases. The VEGFR-2 inhibitory activities of these newly synthesized compounds were also evaluated and compared with that of ZD6

A novel approach to quinazolin-4(3H)-one via quinazoline oxidation: an improved synthesis of 4-anilinoquinazolines

Marzaro, Giovanni,Guiotto, Adriano,Pastorini, Giovanni,Chilin, Adriana

experimental part, p. 962 - 968 (2010/03/25)

A novel strategy to prepare 4-anilinoquinazoline derivatives based on the oxidation of the quinazoline ring is described. Quinazoline oxidation has been investigated and improved, thus leading to an efficient and high yielding method to quinazolin-4(3H)-ones. Efficiency of this approach has been evaluated synthesizing four well known tyrosine kinase inhibitors and comparing the obtained yields with those achievable through conventional synthetic methods.

Therapeutic quinazoline derivatives

-

, (2008/06/13)

A compound of formula (I) or a salt, ester, amide or prodrug thereof; where X is O, or S, S(O), S(O)2 or NR6 where R6 is hydrogen of C1-6alkyl; R5 is an optionally substituted 6-membered aromatic ring containing at least one nitrogen atom, and R1, R2, R3, R4 are independently selected from halogeno, cyano, nitro, C1-3alkylsulphanyl, —N(OH)R7— (wherein R7 is hydrogen, or C1-3alkyl), or R9X1— (wherein X1 represents a direct bond, —O—, —CH2—, —OC(O), —C(O)—, —S—, —SO—, —SO2—, —NR10C(O)—, —C(O)NR11—, —SO2NR12—, —NR13SO2— or NR14— (wherein R10, R11, R12, R13 and R14 each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl), and R9 is hydrogen, optionally substituted hydrocarbyl, optionally substituted heterocyclyl or optionally substituted alkoxy; provided that at least one of R2 or R3 is other than hydrogen. These compounds inhibit aurora 2 kinase and are useful in the preparation of medicaments for the treatment of proliferative disease such as cancer.

Benzazole analogues and uses thereof

-

Page/Page column 24, (2008/06/13)

The present invention relates to N2-heteroaryl-benzazole-2,(5 or 6)-diamine derivatives and compositions thereof as protein kinase inhibitors for the treatment of e.g. cancer.

QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS

-

Page/Page column 22, (2010/11/08)

The invention relates to quinazoline derivatives of the formula I:- wherein: m is an integer from 1 to 3; R 1 represents halogeno or C 1-3 alkyl; X 1 represents -O-; R 2 is selected from one of the following three groups: 1) C 1-5 alkylR 3 (wherein R 3 is piperidin-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C 1-4 alkyl, C 1-4 hydroxyalkyl and C 1-4 alkoxy; 2) C 2-5 alkenylR 3 (wherein R 3 is as defined hereinbefore); 3) C 2-5 alkynylR 3 (wherein R 3 is as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

Fluorine-18 labeling of 6,7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: Synthesis of18F-Iressa and related molecular probes

Seimbille, Yann,Phelps, Michael E.,Czernin, Johannes,Silverman, Daniel H. S.

, p. 829 - 843 (2007/10/03)

Inhibitors of tyrosine kinase enzymatic activity represent a promising new class of antineoplastic agents. Although clinical studies performed over the last decade give more insight on the potential therapeutic applications of such drugs, identification of the individual patients who might benefit from them remains a major challenge. We have developed a synthetic strategy for the production of a wide variety of radiolabeled 6,7-disubstituted 4-anilinoquinazolines suitable for noninvasive imaging of tyrosine kinase receptors to predict therapy effectiveness. Three new F-18 labeled radiopharmaceuticals based on the therapeutic agents Tarceva, Iressa, and ZD6474 were synthesized. Decay-corrected yields varied between 25 and 40% for a total synthesis time of 120 min, thus providing F-18 labeled tyrosine kinase inhibitors in quantities and times practical for use as PET radiopharmaceuticals. Copyright

QUINAZOLINE DERIVATIVES

-

Page/Page column 36, (2010/02/11)

The invention relates to the use of compounds of the formula I: wherein: ring C is a 5-6 membered heterocyclic moiety; Z is -O-, -S-, or -CH2-; R1 is hydrogen, C1-4alkyl, C1-4alkoxymethyl, di(C1-4)alkoxy)methyl, C1-4alkanoyl, trifluoromethyl, cyano, amino, C2-5alkenyl, C2-5alkynyl, carboxy, C3-7cycloalkyl, C3-7-cycloalkylC1-3alkyl, or an optionally substituted group selected from phenyl, benzyl, phenylC2-4alkyl and a 5-6 membered heterocyclic group; n is an integer from 0 to 5; m is an integer from 0 to 3; R2 represents hydrogen, hydroxy, halgeno, cyano, nitro, trifluoromethyl, C1-3alkyl, C1-3alkoxy, C1-3alkylsulphanyl, -NR3R4 (wherein R3 and R4, which may be the same or different, each represents hydrogen or C1-3alkyl), or R5X1- (wherein X1 represents a direct bond, -CH2-, or a heteroatom linker group and R5 is an alkyl, alkenyl or alkynyl chain optionally substituted by for example hydroxy, amino, nitro, alkyl, cycloalkyl, alkoxyalkyl, or an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring, which alkyl, alkenyl or alkynyl chain may have a heteroatom linker group, or R5 is an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring, and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

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