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CAS

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2708-77-2

4-FLUORO-DL-GLUTAMIC ACID is an amino acid derivative with a fluorine atom substitution at the 4th position. It is a key component in the synthesis of various pharmaceutical compounds and serves as a valuable tool in the medical field for diagnostic purposes.

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  • 2708-77-2 Structure

  • Basic information

    1. Product Name: 4-FLUORO-DL-GLUTAMIC ACID
    2. Synonyms: DL-4-FLUOROGLUTAMIC ACID;(+/-)-2-AMINO-4-FLUOROGLUTARIC ACID;4-FLUORO-DL-GLUTAMIC ACID;4-FLUOROGLUTAMIC ACID;H-4-F-DL-Glu-OH;DL-4-Fluoroglutamic acid 98%;DL-4-Fluoroglutamicacid98%;4-FLUORO-DL-GLUTAMIC ACID 97%
    3. CAS NO:2708-77-2
    4. Molecular Formula: C5H8FNO4
    5. Molecular Weight: 165.12
    6. EINECS: 220-302-8
    7. Product Categories: N/A
    8. Mol File: 2708-77-2.mol

  • Chemical Properties

    1. Melting Point: 185°C (dec.)
    2. Boiling Point: 342.4 °C at 760 mmHg
    3. Flash Point: 160.9 °C
    4. Appearance: /
    5. Density: 1.498 g/cm3
    6. Vapor Pressure: 1.37E-05mmHg at 25°C
    7. Refractive Index: 1.491
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 2.06±0.10(Predicted)
    11. BRN: 1947477
    12. CAS DataBase Reference: 4-FLUORO-DL-GLUTAMIC ACID(CAS DataBase Reference)
    13. NIST Chemistry Reference: 4-FLUORO-DL-GLUTAMIC ACID(2708-77-2)
    14. EPA Substance Registry System: 4-FLUORO-DL-GLUTAMIC ACID(2708-77-2)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2708-77-2(Hazardous Substances Data)

2708-77-2 Usage

Uses

Used in Pharmaceutical Synthesis:
4-FLUORO-DL-GLUTAMIC ACID is used as a reagent for the synthesis of analogues of Methotrexate (M260675), a drug that is utilized in the treatment of acute leukemia, breast carcinoma, and rheumatoid arthritis. Its unique structure allows for the development of novel therapeutic agents with potential improvements in efficacy and safety.
Used in Medical Imaging:
In the medical field, the labelled form of 4-FLUORO-DL-GLUTAMIC ACID is employed as an amino acid radiotracer for the imaging of tumors. This application aids in the detection and monitoring of cancerous growths, providing valuable information for diagnosis and treatment planning.

Check Digit Verification of cas no

The CAS Registry Mumber 2708-77-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,7,0 and 8 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2708-77:
(6*2)+(5*7)+(4*0)+(3*8)+(2*7)+(1*7)=92
92 % 10 = 2
So 2708-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H8FNO4/c6-2(4(8)9)1-3(7)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)/t2?,3-/m0/s1

2708-77-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Alfa Aesar

  • (L10517)  4-Fluoro-DL-glutamic acid, erythro + threo, 97%   

  • 2708-77-2

  • 25mg

  • 281.0CNY

  • Detail

  • Alfa Aesar

  • (L10517)  4-Fluoro-DL-glutamic acid, erythro + threo, 97%   

  • 2708-77-2

  • 100mg

  • 853.0CNY

  • Detail

  • Aldrich

  • (89377)  4-Fluoro-DL-glutamicacid  ≥93%

  • 2708-77-2

  • 89377-100MG-F

  • 1,304.55CNY

  • Detail

2708-77-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-FLUORO-DL-GLUTAMIC ACID

1.2 Other means of identification

Product number -
Other names DL-erythro-4-fluoroglutamic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2708-77-2 SDS

2708-77-2Relevant articles and documents

Chemistry of 4-fluoroglutamic acid. Part 2. Separation of the diastereomers on a large scale. Preparation of cis- and trans-4-fluoro-5-pyrrolidone-2-carboxylic acids (4-fluoropyroglutamic acids)

Tolman, V.,Vlasakova, V.,Nemecek, J.

, p. 185 - 191 (2007/10/02)

Separation of the 4-fluoroglutamic acid diastereomers has been achieved by crystalization of the hydrochlorides of their dialkyl esters 1b and 2d.Subsesquent hydrolysis afforded the diastereomers 1a and 2a in 100percent steric purity.Conversion of the acids into the 5-methyl esters followed by treatment with ammonia gives rise to the trans and cis isomers of 4-fluoro-5-pyrrolidine-2-carboxylic acid, 3 and 4.NMR data are given.

Chemistry of 4-fluoroglutamic acid. Part 1. A critical survey of its syntheses: an attempt to optimize reaction conditions for large-scale preparation

Tolman, V.

, p. 179 - 183 (2007/10/02)

Synthetic methods for the preparation of 4-fluoroglutamic acid (1) are reviewed.The utility of every method for routine laboratory work is evaluated with respect to the accessibility of starting materials and reagents, the overall yields and also from the viewpoint of safety.Optimum reaction conditions are given for the selected pathway, suitable for large-scale synthesis.

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