2831-60-9Relevant articles and documents
Ligand-Free Copper-Catalyzed Ullmann-Type C?O Bond Formation in Non-Innocent Deep Eutectic Solvents under Aerobic Conditions
Capriati, Vito,García-álvarez, Joaquín,Marinò, Manuela,Perna, Filippo M.,Quivelli, Andrea Francesca,Vitale, Paola
, (2021/12/09)
An efficient and novel protocol was developed for a Cu-catalyzed Ullmann-type aryl alkyl ether synthesis by reacting various (hetero)aryl halides (Cl, Br, I) with alcohols as active components of environmentally benign choline chloride-based eutectic mixtures. Under optimized conditions, the reaction proceeded under mild conditions (80 °C) in air, in the absence of additional ligands, with a catalyst [CuI or CuII species] loading up to 5 mol% and K2CO3 as the base, providing the desired aryloxy derivatives in up to 98 % yield. The potential application of the methodology was demonstrated in the valorization of cheap, easily available, and naturally occurring polyols (e. g., glycerol) for the synthesis of some pharmacologically active aryloxypropanediols (Guaiphenesin, Mephenesin, and Chlorphenesin) on a 2 g scale in 70–96 % yield. Catalyst, base, and deep eutectic solvent could easily and successfully be recycled up to seven times with an E-factor as low as 5.76.
Preparation method of 2,4-dinitrophenoxyethanol
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Paragraph 0029; 0030, (2017/08/28)
The invention relates to a preparation method of 2,4-dinitrophenoxyethanol. The preparation method comprises the following steps that 1, condensation reaction is conducted, specifically, 2,4-dinitrochlorobene serves as a raw material, is hydrolyzed in an alkaline aqueous solution with the certain concentration and then is condensed with ethylene oxide to obtain condensation reaction liquid; 2, extraction is conducted, specifically, the reaction liquid is dropwise added into a certain organic solvent, layered, concentrated, cooled and crystallized to obtain a crude 2,4-dinitrophenoxyethanol product; and 3, purification is conducted, specifically, the crude 2,4-dinitrophenoxyethanol product is recrystallized to obtain a refined 2,4-dinitrophenoxyethanol product. The preparation method improves the product quality, and also reduces environmental pollution, thereby making product production to be clean and environmentally friendly and enabling products to be more suitable for mass production
2, 4-dinitrophenoxyethanol synthesizing method
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Paragraph 0032; 0033; 0034; 0035; 0036, (2016/10/08)
The invention relates to a 2, 4-dinitrophenoxyethanol synthesizing method, and a product is mainly used for missile servo propellant, a missile servo mechanism, an automobile safe air bag and the like. The synthesizing method includes the steps that 2,4-dinitrochlorobenzene, glycol and strong base are adopted as reactors, deionized water serves as a dispersing agent, a two-step method is adopted to synthesize 2,4-dinitrophenoxyethanol , in the first step, the 2,4-dinitrochlorobenzene is heated and melted and evenly mixed with the glycol to form a system similar to the homogeneous phase, in the second step, a strong base solution is dropwise added to a reaction system for a reaction, then the deionized water is added, the system is further dispersed, and a synthesis reaction is completed. By means of the synthesizing method, the problem that the content change of unitary substituendums and binary substituendums in DNE synthesized in different batches is solved radically, reaction efficiency is high, the yield is high, by-products are harmless, the contents of the unitary substituendums and the binary substituendums are controllable, and the content of the unitary substituendums is controllable within the range from 10% to 95%.
Coupling compounds and hair dyeing compositions containing them
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Page/Page column 10, (2008/06/13)
The present invention refers to compounds of the formula (I) wherein R1 is (C1-C4)-alkyl, (C1-C4)-alkyl which is substituted by hydroxy, (C1-C4)-alkoxy, hydroxy-(C1-C4)-alkoxy, CN, -COOR5, -CON(R5)2 or -N(R5)2 or is phenyl; R2 is hydrogen, methyl or ethyl; R3 is (C1-C4)-alkylsulfonyl, (C1-C4)-alkylsulfonyl which is substituted by hydroxy, halogen, cyano, (C1-C4)-alkoxy or -N(R5)2 or is -SO2-CH=CH2, -SO2N(R5)2 or -PO(OR5)2; R4 is hydrogen, (C2-C4)-alkyl which is substituted by hydroxy, (C1-C4)-alkoxy or hydroxy-(C1-C4)-alkoxy; each of R5, independently is hydrogen, (C1-C4)-alkyl or hydroxy-(C2-C4)-alkyl; whereas R3 is not -NHSO2CH3 if R2 and R4 are both hydrogen and R1 is methyl, as well as hair dye compostions containing them.
Process for the preparation of 1-substituted 2,4-dinitrobenzenes
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, (2008/06/13)
Provided is a process for the preparation of specific 1-substituted 2,4-dinitrobenzenes by reaction of 1-halogeno-2,4-dinitrobenzenes with mono-alkali metal salts of specific diols, in which the 1-halogeno-2,4-dinitrobenzene and the mono-alkali metal salt of the diol are simultaneously added and reacted.
