2850-26-2

Basic information

• Product Name: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate
• Synonyms: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate;Ethyl (tosylmethyl)carbamate;Ethyl N-(p-tolylsulfonylmethyl)carbamate
• CAS NO: 2850-26-2
• Molecular Formula: C₁₁H₁₅NO₄S
• Molecular Weight: 257.3061
• Mol File: 2850-26-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate(2850-26-2)
• EPA Substance Registry System: ethyl n‐[(4‐methylbenzenesulfonyl)methyl]carbamate(2850-26-2)

Safety Data

• Hazardous Substances Data: 2850-26-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Sulindac is used as an anti-inflammatory agent for the treatment of various conditions characterized by pain and inflammation. It is particularly effective for conditions such as arthritis, gout, and ankylosing spondylitis due to its ability to reduce the prostaglandins that cause these symptoms.
Used in Pain Management:
Sulindac serves as an analgesic, helping to alleviate pain associated with inflammatory conditions. Its mechanism of action makes it a suitable option for managing mild to moderate pain that arises from inflammation.
Used in Inflammation Reduction:
As an NSAID, sulindac is used to reduce inflammation in the body. It is particularly useful for conditions where inflammation can lead to joint damage or other complications, such as in the case of arthritis.
Precautionary Note:
While sulindac is effective for its intended uses, it is not without potential side effects. Common side effects include stomach upset, heartburn, and dizziness. More seriously, it may increase the risk of cardiovascular events. Therefore, its use should be carefully considered and monitored under the guidance of a healthcare professional to ensure safety and effectiveness.

Upstream product

• 50-00-0 formaldehyd 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 51-79-6 urethane 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 64-17-5 ethanol 
• 10564-55-3 1-isocyanatomethanesulfonyl-4-methyl-benzene 
• 14738-27-3 ethyl (p-tolylthio)acetate 
• 28126-38-7 N--thiocarbaminsaeure-O-ethylester 
• 2850-19-3 (toluene-4-sulfonyl)-acetic acid ethyl ester 
• 30014-36-9 N-(Tosylmethyl)-carbamoylchlorid 
• 2850-22-8 p-toluenesulfonylacethydrazide 

Downstream Products

• 2881-09-6 p-Toluolsulfonylformaldehyd-(triphenylphosphoranyliden-hydrazon) 
• 7569-26-8 chloromethyl p-tolylsulfone 
• 1538-98-3 p-tosyldiazomethane 
• 15645-75-7 1,1’-[(Z)-ethene-1,2-diyldisulfonyl]bis(4-methylbenzene) 
• 15717-50-7 E-ditosylethene 
• 875011-80-6 (+)-2-n-amyl-2-cyclopropenyl-4-tolyl sulfone 
• 875011-86-2 (-)-cis-1-methyl-4-(2-pentyl-cyclopropanesulfonyl)-benzene 
• 875011-96-4 (+/-)-2-n-amyl-2-cyclopropenyl-4-tolyl sulfone 

Relevant articles and documents

Synthesis method of sulfonyl carbamate

The invention discloses a synthesis method of sulfuryl carbamate, and the method comprises the following steps: by taking sodium aromatic sulfinate, ethyl carbamate and paraformaldehyde as reaction raw materials, carrying out catalytic reaction under the action of a reaction catalyst and under the conditions of heating and pressurizing to prepare the sulfuryl carbamate. The synthesis method is easy and convenient to operate and low in production cost, the adopted synthesis raw materials are low in price, easy to obtain, non-toxic, green and environmentally friendly, the obtained target product is high in purity and ideal in yield, and large-scale production of the sulfuryl carbamate can be achieved.

An Efficient Direct Access to Carbamates from Alcohols and TosMIC Mediated by Iodine in DMSO

A new approach for the synthesis of carbamates from alcohols and TosMIC promoted by iodine/DMSO system is reported. This method offers a one-step, direct and practical strategy for the rapid construction of carbamates under mild conditions. The reaction proceeds via sequential oxidation of isocyanide to isocyanate and nucleophilic addition of alcohols to isocyanate to afford the carbamates in high yields.

Mild oxidation of tosylmethylisocyanide to tosylmethylisocyanate: Utility in synthetic and medicinal chemistry

A convenient and efficient (one-step) oxidation is reported of commercially available tosylmethylisocyanide (TOSMIC) to form tosylmethylisocyanate, making this highly reactive bifunctional molecule a readily available synthetic reagent. Besides engaging in nucleophilic addition reactions with alcohols, amines, and thiols, tosylmethylisocyanate also reacts with carboxylic acids to form tosylmethylamides, which undergo substitution reactions in the presence of organocopper and organomagnesium reagents.

Theory-guided discovery of unique chemical transformations of cyclopropenes

(Chemical Equation Presented) Chiral 2-cyclopropenyl-4-tolyl sulfones, available by the [2 + 1]-cycloaddition of tosyldiazomethane to acetylenes under catalysis by the Rh(II) complex 1, provide a number of unusual transformations and useful chiral product

Improved preparation of tosyldiazomethane

Treatment of the carbamate 2a by i-amyl nitrite and TMSCl in presence of a reduced amount of pyridine, followed by decomposition of the resulting nitroso derivative 3a with activated alumina afforded in high yield the pure, crystalline, diazosulfone 1a, a