29419-15-6

Basic information

• Product Name: 5-Fluoro-2-tetralone
• Synonyms: 5-Fluoro-3,4-dihydronaphthalen-2(1H)-one;5-Fluoro-2-tetralone;Zinc04202736;7-fluoro-3;7-fluoro-1,2,3,4-tetrahydronaphthalen-2-one;2(1H)-Naphthalenone, 7-fluoro-3,4-dihydro-;7-fluoro-3,4-dihydronaphthalen-2(1H)-one;7-Fluoro-3,4-dihydro-2(1H)-naphthalenone
• CAS NO: 29419-15-6
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• Mol File: 29419-15-6.mol

Chemical Properties

• Boiling Point: 265.5 °C at 760 mmHg
• Flash Point: 101.4 °C
• Appearance: /
• Density: 1.199 g/cm³
• Vapor Pressure: 0.00911mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 5-Fluoro-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-tetralone(29419-15-6)
• EPA Substance Registry System: 5-Fluoro-2-tetralone(29419-15-6)

Safety Data

• Hazardous Substances Data: 29419-15-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Fluoro-2-tetralone is utilized as an intermediate in organic synthesis for the production of pharmaceuticals. Its fluoro substitution is advantageous in medicinal chemistry, as it can significantly alter the physicochemical and biological properties of the resulting compounds, potentially enhancing their efficacy and selectivity as drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Fluoro-2-tetralone serves as a key intermediate in the synthesis of agrochemicals. The introduction of fluorine can improve the stability, bioavailability, and target specificity of the final products, leading to more effective and environmentally friendly pesticides or herbicides.
Used in Research and Development:
5-Fluoro-2-tetralone is also employed as a building block in research and development for creating new compounds with potential medicinal or agricultural properties. Its unique structural features make it a valuable tool for exploring novel chemical spaces and discovering innovative molecules with improved therapeutic or pesticidal profiles.

InChI:InChI=1/C10H9FO/c11-9-3-1-7-2-4-10(12)6-8(7)5-9/h1,3,5H,2,4,6H2

Upstream product

• 589-06-0 4-(4-fluorophenyl)butanoic acid 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 352-70-5 m-Fluorotoluene 
• 501-00-8 3-fluorophenylacetonitrile 
• 331-25-9 (3-fluorophenyl)acetic acid 
• 74-85-1 ethene 
• 458-04-8 3-fluorophenylacetyl chloride 

Downstream Products

• 184351-69-7 (7-Fluoro-1-methyl-3,4-dihydro-naphthalen-2-yl)-((R)-1-phenyl-ethyl)-amine 
• 184351-67-5 (7-Fluoro-3,4-dihydro-naphthalen-2-yl)-((R)-1-phenyl-ethyl)-amine 
• 889884-94-0 7-fluoronaphthalen-2-ol 

Relevant articles and documents

FUSED IMIDAZOLE DERIVATIVE

According to the present invention, fused imidazole derivatives of the general formula: wherein R1 is a hydrogen atom, a halogen atom, hydroxy group, a lower alkyl group or a lower alkoxy group, R2 is an aryl group, benzodioxanyl group, or 5-6 membered, monocyclic, unsaturated, heterocyclic group containing nitrogen atom(s) which may be substituted with lower alkyl, trityl or oxo, R3 is a hydrogen atom or hydroxy group, A is a group represented by the formula : -(CH2)m - or -O-(CH2)m- [wherein m is an integer of 1-3] and their salts are provided.

Bicyclic amine derivatives and their use as anti-psychotic agents

This invention relates to compounds of formula (I) STR1 which are useful as modulators of D3 receptors, in particular as antipsychotic agents.

Benzoquinazoline inhibitors of thymidylate synthase: Enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin- 1(2H)-ones

The synthesis and thymidylate synthase (TS) inhibitory activity of a series of simple benzo[f]-quinazolin-1(2H)-ones are described. Fully aromatic 3-amino compounds with compact lipophilic substituents in the 9-position were found to have I50 values as low as 20 nM on the isolated enzyme, and represent the first examples of potent, folate-based TS inhibitors that completely lack any structural feature corresponding to the (p- aminobenzoyl)glutamate moiety of the cofactor. A number of the compounds also showed moderate growth inhibitory activity against a human colon adenocarcinoma cell line (SW480), with IC50 values as low as 2 μM.