305371-16-8

Basic information

• Product Name: [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER;Tert-butyl(4-(2-cyanoacetyl)-6-fluoropyridin-3-yl)carbamate
• CAS NO: 305371-16-8
• Molecular Formula: C₁₃H₁₄FN₃O₃
• Molecular Weight: 279.27
• Mol File: 305371-16-8.mol

Chemical Properties

• Boiling Point: 411.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.285±0.06 g/cm3(Predicted)
• PKA: 5.00±0.16(Predicted)
• CAS DataBase Reference: [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER(305371-16-8)
• EPA Substance Registry System: [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER(305371-16-8)

Safety Data

• Hazardous Substances Data: 305371-16-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER is used as an intermediate compound for the synthesis of various pharmaceuticals. Its role in creating novel compounds with biological activity makes it a valuable asset in the development of new drugs and therapies.
Used in Agrochemical Industry:
In the agrochemical industry, [6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER is utilized as an intermediate in the synthesis of agrochemicals. Its potential to contribute to the development of new compounds with biological activity can lead to the creation of innovative products for agricultural applications, such as pesticides and fertilizers.
Used in Medicinal Chemistry Research:
[6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER is employed as a building block in medicinal chemistry research. Its ability to form novel compounds with biological activity makes it a valuable tool for scientists working on the design and synthesis of new drugs and therapeutic agents.
Used in Drug Development:
[6-FLUORO-4-(3-NITRILOPROPIONYL)PYRIDIN-3-YL]CARBAMIC ACID TERT-BUTYL ESTER is used as a key component in drug development, where its potential to create new biologically active compounds can contribute to the discovery of innovative treatments for various diseases and conditions.

Upstream product

• 75-05-8 acetonitrile 
• 305371-15-7 5-tert-butoxycarbonylamino-2-fluoro-isonicotinic acid, methyl ester 
• 1827-27-6 2-fluoro-5-aminopyridine 
• 171178-41-9 (6-fluoro-pyridin-3-yl)-carbamic acid, tert-butyl ester 
• 171178-42-0 5-[N-(tert-Butoxycarbonyl)-amino]-2-fluoropyridine-4-carboxylic acid 
• 305371-42-0 5-tert-butoxycarbonylamino-2-chloro-isonicotinic acid, methyl ester 
• 4548-45-2 2-chloro-5-nitropyridine 
• 456-24-6 2-Fluoro-5-nitropyridine 

Downstream Products

• 305371-17-9 6-fluoro-4-hydroxy-[1.7]naphthyridine-3-carbonitrile 
• 305371-20-4 4-(3-bromo-phenylamino)-6-(4-methoxy-benzylamino)-[1.7]naphthyridine-3-carbonitrile 
• 305371-18-0 4-chloro-6-fluoro-[1,7]naphthyridine-3-carbonitrile 

Relevant articles and documents

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles

The syntheses and EGFR kinase inhibitory activity of a series of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles are described. Both reversible and irreversible binding inhibitors were prepared. These series were compared with each other and with the corresponding 4-anilinoquinoline-3-carbonitriles. Compounds having a 1,7-naphthyridine core structure can retain high potency while those with a 1,8-naphthyridine core are significantly less active. These results are consistent with molecular modeling observations.

SUBSTITUTED-3-CYANO-[1.7],[1.5], AND [1.8]-NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES

This invention provides compounds of formula (I) having structure (a) wherein A'' is a diavalent moiety selected from the group (a, b, c) which are useful as inhibitors of protein tyrosine kinase.