32483-15-1

Basic information

• Product Name: AC-LEU-NHME
• Synonyms: AC-LEU-NHME;ACETYL-L-LEUCINE METHYL AMIDE;N-ALPHA-ACETYL-L-LEUCINE-N-METHYLAMIDE;AC-LEUCINE-NHME
• CAS NO: 32483-15-1
• Molecular Formula: C9H18N2O2
• Molecular Weight: 186.25
• Mol File: 32483-15-1.mol

Chemical Properties

• Melting Point: 165.3-166.8 °C
• Boiling Point: 409 °C at 760 mmHg
• Flash Point: 176.4 °C
• Appearance: /
• Density: 0.981 g/cm³
• Vapor Pressure: 6.71E-07mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: Store at RT.
• PKA: 14.62±0.46(Predicted)
• CAS DataBase Reference: AC-LEU-NHME(CAS DataBase Reference)
• NIST Chemistry Reference: AC-LEU-NHME(32483-15-1)
• EPA Substance Registry System: AC-LEU-NHME(32483-15-1)

Safety Data

• Hazardous Substances Data: 32483-15-1(Hazardous Substances Data)

Usage

Purification Methods

Recrystallise the amide from EtOAc, EtOH/hexane mixture or toluene/hexane mixture. [Applewhite & Niemann J Am Chem Soc 81 2212 1959.]

InChI:InChI=1/C9H18N2O2/c1-6(2)5-8(9(13)10-4)11-7(3)12/h6,8H,5H2,1-4H3,(H,10,13)(H,11,12)/t8-/m0/s1

Upstream product

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Relevant articles and documents

Oxidative Damage in Aliphatic Amino Acids and Di- and Tripeptides by the Environmental Free Radical Oxidant NO3?: the Role of the Amide Bond Revealed by Kinetic and Computational Studies

Kinetic and computational data reveal a complex behavior of the important environmental free radical oxidant NO3? in its reactions with aliphatic amino acids and di- and tripeptides, suggesting that attack at the amide N-H bond in the peptide backbone is a highly viable pathway, which proceeds through a proton-coupled electron transfer (PCET) mechanism with a rate coefficient of about 1 × 106 M-1 s-1 in acetonitrile. Similar rate coefficients were determined for hydrogen abstraction from the α-carbon and from tertiary C-H bonds in the side chain. The obtained rate coefficients for the reaction of NO3? with aliphatic di- and tripeptides suggest that attack occurs at all of these sites in each individual amino acid residue, which makes aliphatic peptide sequences highly vulnerable to NO3?-induced oxidative damage. No evidence for amide neighboring group effects, which have previously been found to facilitate radical-induced side-chain damage in phenylalanine, was found for the reaction of NO3? with side chains in aliphatic peptides.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

Aqueous Solutions Containing Amino Acids and Peptides. Part 16. --Solute-Solute Interactions in Solutions Containing some N-Acetyl-N'-methylamino Acid Amides

The energetics of the interactions occuring between some N-acetyl-N'-methylamino acid amides in aqueous solutions at 25 deg C have been investigated.Osmotic coefficients and enthalpies of dilution have been obtained for single-component and two-component