327056-62-2

Basic information

• Product Name: 2-Cyano-5-fluoropyridine
• Synonyms: 2-Pyridinecarbonitrile,5-fluoro-(9CI);2-Cyano-5-fluoropyridine, 98+%;5-Fluoropyridine-2-carbonitrile;2-Cyano-5-fluoropyridine;5-Fluoropyridine-2-carbonitrile 97%;5-Fluoropicolinonitrile;2-Cyano-5-fluorpyridine;2-Cyano-5-fluoropyridine, 5-Fluoropicolinonitrile
• CAS NO: 327056-62-2
• Molecular Formula: C₆H₃FN₂
• Molecular Weight: 122.1
• EINECS: -0
• Product Categories: PYRIDINE;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building BlocksHeterocyclic Building Blocks;New Products for Chemical Synthesis;Pyridines;Fluorine series
• Mol File: 327056-62-2.mol

Chemical Properties

• Melting Point: 41-44°C
• Boiling Point: 214.9 °C at 760 mmHg
• Flash Point: 99 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 0.152mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: -2.74±0.10(Predicted)
• CAS DataBase Reference: 2-Cyano-5-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-5-fluoropyridine(327056-62-2)
• EPA Substance Registry System: 2-Cyano-5-fluoropyridine(327056-62-2)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-41-50/53
• Safety Statements: 26-39-60-61
• RIDADR: UN3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 327056-62-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Cyano-5-fluoropyridine is used as a key intermediate for the synthesis of various pharmaceuticals. Its presence in the molecular structure of these drugs contributes to their therapeutic properties, making it an essential component in the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Cyano-5-fluoropyridine is utilized as a building block in the production of agrochemicals. Its incorporation into the molecular structure of these compounds enhances their effectiveness in pest control and crop protection, thereby contributing to increased agricultural productivity.
Used in Dye Industry:
2-Cyano-5-fluoropyridine is employed as a precursor in the synthesis of dyes, imparting specific color characteristics and properties to the final product. Its use in this industry is crucial for the development of high-quality dyes with desired attributes.
Used in Organic Synthesis:
As a versatile building block in organic synthesis, 2-Cyano-5-fluoropyridine is used for the preparation of a wide range of chemical compounds. Its unique structure allows for various chemical reactions, enabling the synthesis of complex molecules with diverse applications.
Safety Precautions:

InChI:InChI=1/C6H3FN2/c7-5-1-2-6(3-8)9-4-5/h1-2,4H

Upstream product

• 89809-64-3 2-cyano-5-chloropyridine 
• 55338-73-3 5-amino-2-cyanopyridine 

Downstream Products

• 915720-54-6 1-(5-fluoropyridin-2-yl)ethan-1-one 
• 107504-08-5 5-fluoropicolinic acid 
• 905587-18-0 N-(1-(5-fluoropyridin-2-yl)vinyl)acetamide 
• 327056-58-6 (Z)-N'-hydroxy-5-fluoropyridine-2-carboxamidine 
• 1032188-85-4 (3-fluoro-5-(trifluoromethyl)phenyl)(5-fluoropyridin-2-yl)methanone 
• 1309591-63-6 C₁₈H₂₀FN₅O₄ 
• 1339045-66-7 5-fluoro-2-(5'-(5''-(4'''-methylpiperazin-1'''-yl)benzimidazol-2''-yl)benzimidazol-2'-yl)pyridine 
• 1351503-91-7 tert-butyl 3-((6-((4-(2-((5-(tert-butyl)isoxazol-3-yl)amino)-2-oxoethyl)phenyl)carbamoyl)pyridin-3-yl)oxy)pyrrolidine-1-carboxylate 
• 1351503-18-8 3-(6-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenylcarbamoyl)pyridin-3-yloxy)-1-isopropylpyrrolidinium methanesulfonate 
• 1351503-17-7 N-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-5-(1-isopropylpyrrolidin-3-yloxy)picolinamide 
• 1351503-16-6 N-(4-(2-(5-tert-butylisoxazol-3-ylamino)-2-oxoethyl)phenyl)-5-(pyrrolidin-3-yloxy)picolinamide hydrochloride 
• 1269626-48-3 6-chloro-5-(2-fluoro-benzyl)-2-(5-fluoro-pyridin-2-yl)-pyrimidin-4-ylamine 
• 1269625-97-9 4-{5-[(2-Fluorophenyl)methyl]-6-(morpholin-4-yl)-2-(pyridin-2-yl)pyrimidin-4-yl}morpholine 
• 1269625-99-1 5-(2-Fluoro-benzyl)-6-morpholin-4-yl-2-(5-morpholin-4-yl-pyridin-2-yl)-pyrimidin-4-ylamine 

Relevant articles and documents

An improved Balz-Schiemann reaction enabled by ionic liquids and continuous processing

A Balz-Schiemann reaction was developed to convert 2-cyano-5-aminopyridine to 2-cyano-5-fluoropyridine. The use of an ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate, BMIMBF4) as a solvent was found to be critical in achieving high assay yields and high selectivity for the fluorination vs. protonation. A process was developed to recycle and reuse the ionic liquid enabling its cost-effective use as a solvent. Finally, the optimal conditions were demonstrated under as a continuous process to address process safety risks associated with diazonium intermediates and the product was used to access a key intermediate in the synthesis of β-amyloid cleaving enzyme 1 inhibitor, verubecestat.

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