905587-18-0

Usage

Uses

Used in Pharmaceutical Research:
N-(1-(5-fluoropyridin-2-yl)vinyl)acetamide is used as a building block for the synthesis of new drug candidates due to its unique chemical structure and potential for diverse biological activities.
Used in Medicinal Chemistry:
N-(1-(5-fluoropyridin-2-yl)vinyl)acetamide is used as a key intermediate in the development of novel pharmaceuticals, leveraging its vinyl group and fluoropyridine moiety to create compounds with specific therapeutic properties.
Used in Drug Discovery Processes:
In the drug discovery industry, N-(1-(5-fluoropyridin-2-yl)vinyl)acetamide is utilized for its potential to contribute to the creation of innovative medications, particularly those targeting various diseases and conditions by interacting with biological systems in unique ways.

Upstream product

• 327056-62-2 5-fluoropicolinonitrile 
• 41404-58-4 2-bromo-5-fluoropyridine 
• 75-16-1 methylmagnesium bromide 
• 108-24-7 acetic anhydride 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 905587-15-7 (S)-1-(5-fluoropyridin-2-yl)-ethanamine 
• 905587-16-8 (S)-tert-butyl-1-(5-fluoropyridin-2-yl)ethylcarbamate 
• 915720-21-7 AZ23 
• 1073149-00-4 (S)-1-(5-fluoropyridin-2-yl)ethanamine hydrochloride 
• 915720-57-9 1-(5-fluoropyridin-2-yl)ethan-1-amine 
• 905587-17-9 N-(1-(5-fluoropyridin-2-yl)ethyl)acetamide 
• 1352624-04-4 (R)-N-(1-(5-fluoropyridin-2-yl)ethyl)acetamide 
• 1202070-39-0 (1R)-1-(5-fluoropyridin-2-yl)ethanamine hydrochloride 
• 905587-17-9 (S)-N-(1-(5-fluoropyridin-2-yl)ethyl)acetamide 

Relevant academic research and scientific papers

Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases

New pyridin-2(1h)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

PYRIDIN-2 (1H) -ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES

Compoundshaving the chemical structure of formula (I) are disclosed; as well as process for theirpreparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

Heteroaryl imidazolone derivatives as jak inhibitors

New heteroaryl imidazolone derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS

New heteroaryl imidazolone derivatives having the chemical structure of formula (I) disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

2-(IMIDAZ0LYLAMIN0)-PYRIDINE DERIVATIVES AND THEIR USE AS JAK KINASE INHIBITORS

The present inv ention relates to compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein Ring A is 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl is optionally substituted on carbon with one or more R6

CHEMICAL COMPOUNDS 000-1

The present invention relates to compounds of Formula (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer.

Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors

The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds.

PYRAZOLYL-AMINO-SUBSTITUTED PYRAZINES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.

5-AMINOPYRAZOL-3-YL-3H-IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I) and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.

AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.