328086-55-1 Usage
Uses
1. Used in Pharmaceutical Industry:
(αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]amino]-2-oxopentyl]-benzenepropanoic Acid is used as an intermediate for the synthesis of rhinovirus protease inhibitors. Its application is crucial in the development of antiviral drugs that target and inhibit the activity of rhinovirus proteases, which are essential for the replication and survival of the virus.
2. Used in Antiviral Research:
In the field of antiviral research, (αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]aMino]-2-oxopentyl]-benzenepropanoic Acid serves as a valuable tool for understanding the mechanisms of viral replication and the design of novel therapeutic strategies. Its role in the synthesis of rhinovirus protease inhibitors can lead to the discovery of new antiviral agents that are effective against a range of viral infections.
3. Used in Drug Development:
(αR)-4-Fluoro-α-[(3S)-4-Methyl-3-[[(5-Methyl-3-isoxazolyl)carbonyl]amino]-2-oxopentyl]-benzenepropanoic Acid is also utilized in the drug development process, where it can be further modified and optimized to enhance the potency, selectivity, and pharmacokinetic properties of the resulting antiviral agents.
Check Digit Verification of cas no
The CAS Registry Mumber 328086-55-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,8,0,8 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 328086-55:
(8*3)+(7*2)+(6*8)+(5*0)+(4*8)+(3*6)+(2*5)+(1*5)=151
151 % 10 = 1
So 328086-55-1 is a valid CAS Registry Number.
328086-55-1Relevant articles and documents
Chemoenzymatic synthesis of ketomethylene tripeptide isosteres
Tao, Junhua,Hu, Shanghui,Tian, Qingping,Nayyar, Naresh,Babu, Srin
, p. 699 - 703 (2007/10/03)
A chemoenzymatic method is described for the synthesis of a desired ketomethylene tripeptide isostere. The key step is an enzymatic hydrolysis, which removes the C-terminal ester-protecting group under mild conditions without epimerizing the existing ster
Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
Shie, Jiun-Jie,Fang, Jim-Min,Kuo, Tun-Hsun,Kuo, Chih-Jung,Liang, Po-Huang,Huang, Hung-Jyun,Wu, Yin-Ta,Jan, Jia-Tsrong,Cheng, Yih-Shyun E.,Wong, Chi-Huey
, p. 5240 - 5252 (2007/10/03)
The proteolytic processing of polyproteins by the 3CL protease of severe acute respiratory syndrome coronavirus is essential for the viral propagation. A series of tripeptide α,β-unsaturated esters and ketomethylene isosteres, including AG7088, are synthesized and assayed to target the 3CL protease. Though AG7088 is inactive (IC50 > 100 μM), the ketomethylene isosteres and tripeptide α,β-unsaturated esters containing both P1 and P2 phenylalanine residues show modest inhibitory activity (IC50 = 11-39 μM). The Phe-Phe dipeptide inhibitors 18a-e are designed on the basis of computer modeling of the enzyme-inhibitor complex. The most potent inhibitor 18c with an inhibition constant of 0.52 μM is obtained by condensation of the Phe-Phe dipeptide α,β-unsaturated ester with 4-(dimethylamino)cinnamic acid. The cell-based assays also indicate that 18c is a nontoxic anti-SARS agent with an EC50 value of 0.18 μM.
