3296-45-5

Basic information

• Product Name: 2-oxo-cyclopentanepropionic acid
• Synonyms: 2-Oxocyclopentanepropanoic acid;3-(2-Oxocyclopentyl)propanoic acid;2-oxo-cyclopentanepropionic acid
• CAS NO: 3296-45-5
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.17908
• EINECS: 221-966-1
• Mol File: 3296-45-5.mol

Chemical Properties

• Boiling Point: 324.2°C at 760 mmHg
• Flash Point: 164.1°C
• Appearance: /
• Density: 1.166g/cm³
• Vapor Pressure: 5.05E-05mmHg at 25°C
• Refractive Index: 1.489
• CAS DataBase Reference: 2-oxo-cyclopentanepropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-cyclopentanepropionic acid(3296-45-5)
• EPA Substance Registry System: 2-oxo-cyclopentanepropionic acid(3296-45-5)

Safety Data

• Hazardous Substances Data: 3296-45-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H12O3/c9-7-3-1-2-6(7)4-5-8(10)11/h6H,1-5H2,(H,10,11)

Upstream product

• 57026-64-9 ethyl 1-(2-ethoxycarbonylethyl)-2-oxocyclopentanecarboxylate 
• 91247-75-5 2-(2-Aethoxycarbonyl-aethyl)-2-cyan-cyclopentanon-⁽¹⁾ 
• 7362-91-6 3-(3-ethoxycarbonyl-2-oxo-cyclopentyl)-propionic acid ethyl ester 
• 58712-11-1 methyl 3-(2-oxo-cyclopentyl)propanoate 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 1552-12-1 1,5-cis,cis-cyclooctadiene 
• 1131-74-4 4-Cycloocten-1-carbonsaeure-ethylester 
• 4104-20-5 3-(2-oxo-cyclopentyl)-propionic acid ethyl ester 
• 1572-39-0 hexane-1,3,6-tricarboxylic acid triethyl ester 
• 2941-29-9 2-oxocyclopentanecarbonitrile 
• 60556-87-8 2-carbonyl-3-butenenitrile 
• 19980-43-9 1-(trimethylsilyloxy)cyclopentene 
• 120-92-3 cyclopentanone 
• 140-88-5 ethyl acrylate 

Downstream Products

• 75066-62-5 3-Oxo-5-(2-oxocyclopentyl)-2-(triphenylphosphoranyliden)pentananilid 
• 6053-54-9 1-oxaspiro[4.4]nonane-2,6-dione 
• 7095-09-2 1-phenyl-3-(2-oxocyclopentyl)-1-propanone 
• 1042308-66-6 (3S,6aS,9aR)-3-(3,4-dimethoxybenzyl)-octahydro-1-oxa-3a-azacyclopenta[d]inden-4-one 
• 1042308-60-0 (3R,6aR,9aS)-3-(3,4-dimethoxybenzyl)-octahydro-1-oxa-3a-azacyclopenta[d]inden-4-one 
• 1489-28-7 1,2,3,6,7,7a-hexahydro-5H-inden-5-one 
• 140-77-2 3-cyclopentylpropionic acid 

Relevant articles and documents

Acyl acid derivative and preparation method and medical application thereof

The invention relates to an acyl acid derivative as well as a preparation method and medical application thereof. Specifically, the invention relates to a compound represented by a general formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the same, and the invention also relates to a use thereof as an active ingredient in the prevention and/or treatment of muscle atrophy-related diseases, including myogenic muscle atrophy, disuse muscle atrophy, senile muscle atrophy, neurogenic muscle atrophy, and a use in the prevention and/or treatment of obesity, fatty liver, cardiovascular and cerebrovascular diseases, metabolic diseases, and anti-aging, wherein the definition of each group in the general formula (I) is the same as the definition in the specification.

Facile Synthesis of Spirocyclic Lactams from β-Keto Carboxylic Acids

A facile synthesis of spirocyclic lactams starting from β-keto carboxylic acids via a one-pot cascade reaction involving a Curtius rearrangement and an intramolecular nucleophilic addition of the enol carbon to the isocyanate intermediate is reported. The same conditions have also been used for the generation of fused cyclic lactams with similar good yields. The synthetic value of this method has been demonstrated by efficient synthesis of tetracyclic spirolactam 8 and pentacyclic spirolactam 9.

Asymmetric synthesis of tetracyclic benzo[a]quinolizidine targets

(Chemical Equation Presented) We report a novel, facile, and asymmetric approach for the synthesis of polycyclic benzo[a]quinolizidine targets. In the formation of more functionalized derivatives, we have observed the generation of an iminium ether salt intermediate, formed during an unprecedented retro-Diels-Alder/N-acyliminium cyclization cascade. The iminium ether intermediate was isolated in good yield, characterized by X-ray crystallography, and subsequently applied as a synthetic building block.

CYANURES D'ACYLE ETHYLENIQUES V: ADDITION CONJUGUEE DES ETHERS D'ENOLS TRIMETHYLSILYLES.

Conjugate addition of silyl enol ethers to ethylenic acyl cyanides leads to δ-keto-acids or methyl esters after hydrolysis or methanolysis of reaction products.