2941-29-9

Basic information

• Product Name: CYCLOPENTANONE-2-CARBONITRILE
• Synonyms: 2-cyanocyclopentanone;2-oxo-cyclopentanecarbonitril;2-oxocyclopentanecarbonitrile;cianociclopentanone;AKOS MSC-0131;Cyclopentan-1-one-2-carbonitrile;Cyclopentanone-2-carbonitrile;2-ketocyclopentanecarbonitrile
• CAS NO: 2941-29-9
• Molecular Formula: C₆H₇NO
• Molecular Weight: 109.13
• Product Categories: pharmacetical
• Mol File: 2941-29-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 258 °C at 760 mmHg
• Flash Point: 109.9 °C
• Appearance: /
• Density: 1.084 g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.464
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: CYCLOPENTANONE-2-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOPENTANONE-2-CARBONITRILE(2941-29-9)
• EPA Substance Registry System: CYCLOPENTANONE-2-CARBONITRILE(2941-29-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 2941-29-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 24, p. 3241, 1994 DOI: 10.1080/00397919408010246Tetrahedron Letters, 25, p. 753, 1984 DOI: 10.1016/S0040-4039(01)80017-4

InChI:InChI=1/C6H7NO/c7-4-5-2-1-3-6(5)8/h5H,1-3H2

Upstream product

• 2321-76-8 2-iminocyclopentanecarbonitrile 
• 90610-26-7 3-cyano-2-oxo-cyclopentanecarboxylic acid ethyl ester 
• 2941-23-3 2-amino-1-cyanocyclopentene 
• 34598-87-3 2-(4-morpholinyl)-1-cyclopentene-1-carbonitrile 
• 19980-43-9 1-(trimethylsilyloxy)cyclopentene 
• 1130-90-1 1-naphthyl cyanate 
• 1122-85-6 phenyl cyanate 
• 120-92-3 cyclopentanone 
• 7148-07-4 1-pyrrolidinocyclopent-1-ene 
• 7664-93-9 sulfuric acid 
• 111-69-3 hexanedinitrile 
• 506-77-4 cyanogen chloride 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 

Downstream Products

• 97183-64-7 2-anilino-cyclopent-1-enecarbonitrile 
• 22394-62-3 2-(3-Phenyl-3-oxo-propyl)-2-cyan-cyclopentanon-⁽¹⁾ 
• 99372-97-1 1-ethyl-2-oxo-cyclopentanecarbonitrile 
• 168846-66-0 (S)-2--3-(4-hydroxyphenyl)propanoate d'ethyle 
• 335421-55-1 2-oxo-1-(3-oxopentyl)cyclopentanecarbonitrile 
• 32116-66-8 2-allyl-2-methylcyclopentan-1-one 
• 150128-13-5 2-benzyl-2-methylcyclopentan-1-one 
• 1123681-66-2 (S)-2-(((S)-tert-butoxycarbonylamino)(2-methylphenyl)methyl)-2-cyanocyclopentanone 

Relevant articles and documents

COMPOUNDS USEFUL AS CSF1 MODULATORS

This invention relates to novel compounds and to pharmaceutical compositions comprising the novel compounds. More specifically, the invention relates to compounds useful as Colony Stimulating Factor 1 Receptor (cFMS) modulators (e.g. cFMS inhibitors). This invention also relates to processes for preparing the compounds, uses of the compounds in treatment and methods of treatment employing the compounds. Specifically, the invention relates to the use of the compounds for the treatment of cancer and autoimmune diseases.

An Alternative to the Classical α-Arylation: The Transfer of an Intact 2-Iodoaryl from ArI(O2CCF3)2

The α-arylation of carbonyl compounds is generally accomplished under basic conditions, both under metal catalysis and via aryl transfer from the diaryl λ3-iodanes. Here, we describe an alternative metal-free α-arylation using ArI(O2CCF3)2 as the source of a 2-iodoaryl group. The reaction is applicable to activated ketones, such as α-cyanoketones, and works with substituted aryliodanes. This formal C-H functionalization reaction is thought to proceed through a [3,3] rearrangement of an iodonium enolate. The final α-(2-iodoaryl)ketones are versatile synthetic building blocks.

A modified Robinson annulation process to α,α-disubstituted-β,γ-unsaturated cyclohexanone system. Application to the total synthesis of nanaimoal

4-Cyano-2-cyclohexenones were found to be susceptible to reductive alkylation reactions, giving the corresponding 2,2-disubstituted-3-cyclohexenone derivatives in a completely regioselective manner. This newly developed methodology has been successfully applied towards the total synthesis, in racemic form, of the marine natural product nanaimoal.