33244-57-4Relevant articles and documents
Direct and site-selective palladium-catalyzed c-7 acylation of indolines with aldehydes
Shin, Youngmi,Sharma, Satyasheel,Mishra, Neeraj Kumar,Han, Sangil,Park, Jihye,Oh, Hyunji,Ha, Jimin,Yoo, Hyunwu,Jung, Young Hoon,Kima, In Su
, p. 594 - 600 (2015)
The palladium-catalyzed oxidative acylation of indolines at the C-7 position with aldehydes or alcohols via C-H bond activation is described. This protocol represents a facile access to 7-acylated indolines, which can be readily transformed into 7-acylated indoles with diverse biological properties.
Selective C-H Olefination of Indolines (C5) and Tetrahydroquinolines (C6) by Pd/S,O-Ligand Catalysis
Jia, Wen-Liang,Westerveld, Nick,Wong, Kit Ming,Morsch, Thomas,Hakkennes, Matthijs,Naksomboon, Kananat,Fernández-Ibá?ez, M. ángeles
supporting information, p. 9339 - 9342 (2019/11/21)
Herein, we report a highly selective C-H olefination of directing-group-free indolines (C5) and tetrahydroquinolines (C6) by Pd/S,O-ligand catalysis. In the presence of the S,O-ligand, a wide range of challenging indolines, tetrahydroquinolines, and olefins was efficiently olefinated under mild reaction conditions. The synthetic potential of this methodology was demonstrated by the efficient olefination of several indoline-based natural products.
NOVEL LIGAND COMPOUND AND TRANSITION METAL COMPOUND COMPRISING THE SAME
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Paragraph 0163; 0165-0168, (2017/04/14)
The present invention relates to a novel ligand compound and a transition metal compound containing the same. The novel ligand compound and the transition metal compound containing the same according to the present invention can be used as a polymerizatio
METHOD OF PREPARING LIGAND COMPOUND AND TRANSITION METAL COMPOUND
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Paragraph 0206-0208, (2017/03/14)
The present invention relates to a method of preparing a ligand compound and a transition metal compound comprising the same. An olefin based polymer with excellent material properties can be obtained using the transition metal compound obtained by said m
Diaryl-substituted (Dihydro)pyrrolo[3,2,1- hi ]indoles, a class of potent COX-2 inhibitors with tricyclic core structure
Laube, Markus,Gassner, Cemena,Sharma, Sai Kiran,Günther, Robert,Pigorsch, Arne,K?nig, Jonas,K?ckerling, Martin,Wuest, Frank,Pietzsch, Jens,Kniess, Torsten
, p. 5611 - 5624 (2015/06/16)
A new compound class of diaryl-substituted heterocycles with tricyclic dihydropyrrolo[3,2,1-hi]indole and pyrrolo[3,2,1-hi]indole core structures has been designed and was synthesized by a modular sequence of Friedel-Crafts acylation, amide formation, and
Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: A facile strategy for the synthesis of 7-substituted indoles
Kim, Minyoung,Kumar Mishra, Neeraj,Park, Jihye,Han, Sangil,Shin, Youngmi,Sharma, Satyasheel,Lee, Youngil,Lee, Eui-Kyung,Kwak, Jong Hwan,Kim, In Su
, p. 14249 - 14252 (2014/12/11)
Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C-H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles. This journal is
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6,7,1-hi]indoles: Discovery of potent, selective phosphodiesterase type 4 inhibitors
Burnouf,Auclair,Avenel,Bertin,Bigot,Calvet,Chan,Durand,Fasquelle,Féru,Gilbertsen,Jacobelli,Kebsi,Lallier,Maignel,Martin,Milano,Ouagued,Pascal,Pruniaux,Puaud,Rocher,Terrasse,Wrigglesworth,Doherty
, p. 4850 - 4867 (2007/10/03)
The synthesis, structure-activity relationships, and biological properties of a novel series of potent and selective phosphodiesterase type 4 (PDE4) inhibitors are described. These new aminodiazepinoindoles displayed in vitro PDE4 activity with submicromo
Synthesis and structure-activity relationships of 4-oxo-1-phenyl- 3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: Novel PDE4 inhibitors
Pascal, Yves,Andrianjara, Charles R.,Auclair, Eric,Avenel, Nadine,Bertin, Bernadette,Calvet, Alain,Feru, Frederic,Lardon, Sophie,Moodley, Indres,Ouagued, Malika,Payne, Adrian,Pruniaux, Marie-Pierre,Szilagyi, Corinne
, p. 35 - 38 (2007/10/03)
A novel series of benzodiazepine derivatives have been discovered as inhibitors of PDE4 enzymes. We have found that our compounds are selective versus other PDE enzymes, and that the activity can be modulated by specific structural modifications. One compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized Brown-Norway rats (compound 9, 5.1 mg/kg p.o.), moreover this compound is not emetic at 3 mg/kg i.v.
Studies on a novel, potent and orally effective cholecystokinin A antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds
Satoh,Matsuo,Sogabe,Itoh,Tada,Kinoshita,Yoshida,Takaya
, p. 2071 - 2083 (2007/10/02)
We prepared various novel tricyclic 1,4-benzodiazepine derivatives as cholecystokinin (CCK) A antagonists, which were evaluated preliminarily for inhibition of 125I-CCK-8 binding to rat pancreatic membranes in vitro and inhibiting effect on CCK
Ortho-mono-substituted amino)phenylimines
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, (2008/06/13)
Novel ortho-(mono-substituted amino)phenylimines being intermediates to psychotropic drugs and other drugs are economically and industrially prepared by reacting anilines with nitriles in the presence of a boron trifluoride ether adduct and a halide-type