33674-97-4

Basic information

• Product Name: (6-Chloro-2-pyridinyl)methanol
• Synonyms: CHEMPACIFIC 38159;(6-CHLORO-PYRIDIN-2-YL)-METHANOL;(6-Chloro-2-pyridinyl)methanol;2-Chloro-6-(Hydroxymethyl)Pyridine;6-Chloro-2-pyridinemethanol;2-Chloropyridine-6-Methanol
• CAS NO: 33674-97-4
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: -0
• Mol File: 33674-97-4.mol

Chemical Properties

• Boiling Point: 251.8 °C at 760 mmHg
• Flash Point: 106.1 °C
• Appearance: /
• Density: 1.324 g/cm³
• Vapor Pressure: 0.0105mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 13.12±0.10(Predicted)
• CAS DataBase Reference: (6-Chloro-2-pyridinyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (6-Chloro-2-pyridinyl)methanol(33674-97-4)
• EPA Substance Registry System: (6-Chloro-2-pyridinyl)methanol(33674-97-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 33674-97-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(6-Chloro-2-pyridinyl)methanol is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
(6-Chloro-2-pyridinyl)methanol is used as a starting material in the production of agrochemicals, particularly those with bactericidal and fungicidal properties, to protect crops and enhance agricultural productivity.
Used in Chemical Production:
(6-Chloro-2-pyridinyl)methanol serves as an intermediate in the synthesis of other chemicals, facilitating the creation of a wide range of compounds for various applications across different industries.
Used in Medicine:
(6-Chloro-2-pyridinyl)methanol is utilized in the medical field for its potential applications in the development of new treatments and therapies, thanks to its chemical properties and reactivity.
Used in Agriculture:
(6-Chloro-2-pyridinyl)methanol is employed in agriculture as a component in the formulation of bactericidal and fungicidal agents to protect plants from diseases and pests, thereby improving crop yields and quality.

InChI:InChI=1/C6H6ClNO/c7-6-3-1-2-5(4-9)8-6/h1-3,9H,4H2

Upstream product

• 67-56-1 methanol 
• 116570-79-7 N-methoxy-2-chloropyridinium methylsulfate 

Downstream Products

• 54087-03-5 6-chloropyridine-2-carboxaldehyde 
• 78152-53-1 2-Chloro-6-(dichloromethyl)-pyridine 
• 460720-22-3 6-chloro-2-phenylthiomethylpyridine 
• 253686-25-8 α-fluoro-6-(4-phenylpiperazinyl)-2-picoline N-oxide 
• 108337-79-7 2,6-dimethyl-4-(6-chloro-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino)ethyl ester 5-methyl ester 
• 75279-60-6 2-(6-chloropyridin-2-yl)acetonitrile 
• 933734-79-3 C₇H₉ClN₂ 
• 105243-77-4 (6-(methylamino)pyrid-2-yl)methanol 
• 63763-79-1 2-chloro-6-(bromomethyl)pyridine 
• 208110-94-5 2-(benzyloxy)-6-<2-(trimethylsilanyl)ethoxymethoxymethyl>pyridine 
• 208110-88-7 6-(furan-2-yl)pyridine-2-carboxaldehyde 
• 208111-00-6 6-(thien-2-yl)pyridine-2-carboxyaldehyde 

Relevant articles and documents

Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms

Considering the synthetic relevance of heteroarenes in various areas ranging from organic synthesis to medicinal chemistry, developing practically simple methodologies to access functionalized heteroarenes is of a significant value. Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation. The synthetic importance of the developed reactions is demonstrated by the synthesis of biologically relevant compounds. Electron paramagnetic resonance spectroscopy, quantum yield measurements, and density-functional theory calculations allowed us to understand reaction mechanisms of both photocatalytic reactions.

Substituted 2-acylpyridine-α-(N)-hetarlyhydrazones and medicaments containing the same

Substituted 2-acylpyridine-α-(N)-hetarylhydrazones are described, which are suitable as active substances for the treatment of antimicrobial and in particular antimycobacterial diseases, as well as active substances for the treatment of malaria or malignant tumours. The compounds have a marked synergistic activity combined with inhibitors of folate synthase, dihydrofolic acid reductase, DNA-synthesis and RNA-synthesis.