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5-Bromo-1,3-phenylenediamine is a chemical compound known for its diverse applications in various industries and research fields. It is characterized by its ability to participate in the synthesis of pharmaceuticals, dyes, and pigments, and is recognized for its potential as an antioxidant, antiviral, and antitumor agent.

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  • 33786-90-2 Structure
  • Basic information

    1. Product Name: 5-Bromo-1,3-phenylenediamine
    2. Synonyms: 5-Bromo-1,3-benzenediamine;5-Bromo-1,3-phenylenediamine;5-Bromobenzene-1,3-diamine;1-Bromo-3,5-diaminobenzene, 5-Bromophenylene-1,3-diamine;5-Bromo-3-amino-aniline;1-Bromo-3,5-Diaminobenzene;3,5-Diamino-bromobenzene
    3. CAS NO:33786-90-2
    4. Molecular Formula: C6H7BrN2
    5. Molecular Weight: 187.04
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 33786-90-2.mol
  • Chemical Properties

    1. Melting Point: 92 °C
    2. Boiling Point: 336.144 °C at 760 mmHg
    3. Flash Point: 157.094 °C
    4. Appearance: /
    5. Density: 1.698 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    8. Solubility: N/A
    9. PKA: 3.81±0.10(Predicted)
    10. CAS DataBase Reference: 5-Bromo-1,3-phenylenediamine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-Bromo-1,3-phenylenediamine(33786-90-2)
    12. EPA Substance Registry System: 5-Bromo-1,3-phenylenediamine(33786-90-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 33786-90-2(Hazardous Substances Data)

33786-90-2 Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-1,3-phenylenediamine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic properties.
Used in Dye and Pigment Industry:
5-Bromo-1,3-phenylenediamine is used as a precursor in the production of dyes and pigments, where its chemical structure allows for the creation of a wide range of colorants for different applications.
Used in Hair Dye Industry:
5-Bromo-1,3-phenylenediamine is used as an active ingredient in hair dyes, providing coloration effects and contributing to the formulation of hair care products.
Used in Organic Chemistry Research:
5-Bromo-1,3-phenylenediamine is used as a reagent in organic chemistry reactions, facilitating various chemical processes and contributing to the advancement of chemical research.
Used in Antioxidant Applications:
5-Bromo-1,3-phenylenediamine is studied for its potential use as an antioxidant, where it can scavenge free radicals, thereby protecting cells from oxidative damage and potentially reducing the risk of certain diseases.
Used in Antiviral Applications:
5-Bromo-1,3-phenylenediamine is investigated for its potential as an antiviral agent, with the capacity to inhibit viral replication, offering a possible therapeutic approach against viral infections.
Used in Antitumor Applications:
5-Bromo-1,3-phenylenediamine is explored for its potential role in combating certain types of cancer through its antitumor properties, suggesting a possible contribution to cancer treatment and therapy.

Check Digit Verification of cas no

The CAS Registry Mumber 33786-90-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,7,8 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 33786-90:
(7*3)+(6*3)+(5*7)+(4*8)+(3*6)+(2*9)+(1*0)=142
142 % 10 = 2
So 33786-90-2 is a valid CAS Registry Number.

33786-90-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-bromobenzene-1,3-diamine

1.2 Other means of identification

Product number -
Other names 5-BROMO-1,3-PHENYLENEDIAMINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33786-90-2 SDS

33786-90-2Relevant articles and documents

A radiobrominated tyrosine kinase inhibitor for egfr with l858r/t790m mutations in lung carcinoma

Fawwaz, Muammar,Mishiro, Kenji,Nishii, Ryuichi,Makino, Akira,Kiyono, Yasushi,Shiba, Kazuhiro,Kinuya, Seigo,Ogawa, Kazuma

, (2021/03/29)

Activating double mutations L858R/T790M in the epidermal growth factor receptor (EGFR) region are often observed as the cause of resistance to tyrosine kinase inhibitors (TKIs). Third‐generation EGFR‐TKIs, such as osimertinib and rociletinib (CO‐1686), wa

Elastic orange emissive single crystals of 1,3-diamino-2,4,5,6-tetrabromobenzene as flexible optical waveguides

Bhaktha B. N., Shivakiran,Biradha, Kumar,Choubey, Priyanka S.,Das, Susobhan,Gude, Venkatesh,Reddy, C. Malla

, p. 9465 - 9472 (2021/08/10)

Single crystals of monoaromatic compounds exhibiting both mechanical softness and optical properties have attracted significant scientific interest in recent years, but they are very scarce. Herein, single crystals of 1,3-diamino-2,4,5,6-tetrabromobenzene

COMPOSITIONS FOR THE TREATMENT OF PULMONARY FIBROSIS

-

Paragraph 00125-00126, (2018/02/28)

The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.

A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790Mmutant with improved pharmacokinetic properties

Yu, Lei,Huang, Minhao,Xu, Tianfeng,Tong, Linjiang,Yan, Xiao-e,Zhang, Zhang,Xu, Yong,Yun, Caihong,Xie, Hua,Ding, Ke,Lu, Xiaoyun

supporting information, p. 1107 - 1117 (2016/12/30)

Structural optimization of pyrido[2,3-d]pyrimidin-7-ones was conducted to yield a series of new selective EGFRT790Minhibitors with improved pharmacokinetic properties. One of the most promising compound 9s potently suppressed EGFRL858R/T790Mkinase and inhibited the proliferation of H1975?cells with IC50values of 2.0?nM and 40?nM, respectively. The compound dose-dependently induced reduction of the phosphorylation of EGFR and downstream activation of ERK in NCI[sbnd]H1975?cells. It also exhibited moderate plasma exposure after oral administration and an oral bioavailability value of 16%. Compound 9s may serve as a promising lead compound for further drug discovery overcoming the acquired resistance of non-small cell lung cancer (NSCLC) patients.

Activated carbon as an efficient support for gold nanoparticles that catalyze the hydrogenation of nitro compounds with molecular hydrogen

Bondarenko, Grigory N.,Beletskaya, Irina P.

, p. 443 - 445 (2015/12/30)

A catalyst based on activated carbon with deposited gold nanoparticles and impregnated with ethylenediamine for selective hydrogenation of nitroarenes has been suggested.

AMINOPYRIMIDINES AS SYK INHIBITORS

-

Page/Page column 259-260, (2011/07/07)

The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.

Copper(I)-Induced Bromo-Hydrogen Exchange of 2,3-Dibromoanilines

Liedholm, Brita

, p. 877 - 884 (2007/10/02)

The copper(I)-induced bromine-hydrogen exchange reaction of 2,3-dibromoaniline and 5-substituted 2,3-dibromoanilines in the 2-position has been kinetically studied in water-acetic acid-hydrochloric acid medium at 90 deg C.The dehalogenation reaction is of second order, first order in both substrate and Cu+, and may be interpreted as a reductive substitution, composed of two one-electron steps.The 2,3-dibromophenol was only qualitatively investigated, but gave similar results.

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