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3-Fluoro-2-hydroxybenzoic acid is a chemical compound characterized by the molecular formula C7H5FO3. It is a derivative of benzoic acid, featuring a hydroxyl group and a fluorine atom attached to the benzene ring. 3-Fluoro-2-hydroxybenzoic acid is widely recognized for its utility in organic synthesis and pharmaceutical research, where it serves as a key intermediate in the production of a variety of drugs and bioactive compounds. Its intriguing chemical structure and properties have positioned 3-Fluoro-2-hydroxybenzoic acid as a significant compound for ongoing study and development, particularly within the pharmaceutical industry.

341-27-5

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341-27-5 Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-2-hydroxybenzoic acid is utilized as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and bioactive compounds. Its unique structure allows for the creation of molecules with specific therapeutic properties, making it a valuable asset in drug discovery and medicinal chemistry.
Used in Organic Synthesis:
In the realm of organic synthesis, 3-Fluoro-2-hydroxybenzoic acid is employed as a building block for the creation of complex organic molecules. Its presence in the synthesis process can influence the reactivity, selectivity, and final properties of the synthesized compounds, thereby expanding the scope of organic chemistry and its applications.
Used in Research and Development:
3-Fluoro-2-hydroxybenzoic acid is also used as a research compound for studying its chemical properties and potential interactions with biological systems. This research is crucial for understanding how such compounds can be modified or used to create new pharmaceuticals, materials, or other applications that can benefit from its unique characteristics.

Check Digit Verification of cas no

The CAS Registry Mumber 341-27-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 1 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 341-27:
(5*3)+(4*4)+(3*1)+(2*2)+(1*7)=45
45 % 10 = 5
So 341-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H5FO3/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,9H,(H,10,11)

341-27-5 Well-known Company Product Price

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  • Alfa Aesar

  • (H26163)  3-Fluorosalicylic acid, 99%   

  • 341-27-5

  • 500mg

  • 946.0CNY

  • Detail
  • Alfa Aesar

  • (H26163)  3-Fluorosalicylic acid, 99%   

  • 341-27-5

  • 2g

  • 2421.0CNY

  • Detail

341-27-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-FLUORO-2-HYDROXYBENZOIC ACID

1.2 Other means of identification

Product number -
Other names 3-fluoro-2-hydroxy-benzoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:341-27-5 SDS

341-27-5Relevant articles and documents

A short and efficient preparation of methyl-[1,2,4]oxadiazolium derivatives with plant-inducing activity

Dobler, Markus R.

, p. 963 - 964 (2007/10/03)

A short and efficient preparation of methyl-[1,2,4]oxadiazolium derivatives with plant-inducing activity is discussed. A concise and efficient synthetic method leading to structurally diverse array of oxadiazolium derivatives, starting from halogenated phenols is also developed. The starting point of the synthesis is the Lewis acid mediated addition of isocyanates to phenols. The strategy also involves a new and rapid access to all meta-halogenated salicylic acids, compounds of high synthetic value.

Fluorophenols and (trifluoromethyl)phenols as substrates of site-selective metalation reactions: To protect or not to protect

Marzi, Elena,Mongin, Florence,Spitaleri, Andrea,Schlosser, Manfred

, p. 2911 - 2915 (2007/10/03)

O-Methoxymethyl (MOM) protected fluorophenols can be cleanly metalated and subsequently be submitted to site-selective electrophilic substitution. The 2- and 4-isomers exhibit ambivalent reactivity: deprotonation occurs at the position adjacent to the oxygen when butyllithium is employed whereas the position adjacent to the fluorine is attacked by the superbasic mixture of butyllithium and potassium tert-butoxide (LIC-KOR). The MOM-protected (trifluoromethyl)-phenols react exclusively at oxygen-neighboring positions. The meta isomer provides another example of optional site selectivity, undergoing hydrogen/metal exchange at the 2-position with the LIC-KOR reagent and at the 6-position with sec-butyllithium. Unprotected (trifluoromethyl)phenols can also be ortho-metalated after O-deprotonation, although the products are formed in only moderate yields.

A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen-metal exchange of substituted mom protected phenols followed by carboxylation

Lau, Stephen Y.W.,Keay, Brian A.

, p. 1541 - 1545 (2007/10/03)

A highly efficient synthesis of various 3-substituted salicylic acids is described starting from inexpensive starting materials and requiring no special apparatus.

An improved method for the synthesis of 3-fluorosalicylic acid with application to the synthesis of 3-(Trifluoromethyl)salicylic acid

Micklatcher, Mark L.,Cushman, Mark

, p. 1878 - 1880 (2007/10/03)

An improved method for the synthesis of 3-fluorosalicylic acid is described. A positional protective group strategy allows formylation selectively at the ortho position of 4-bromo-2-fluorophenol. Oxidation of the resulting salicylaldehyde to the salicylic acid, followed by debromination, affords 3-fluorosalicylic acid. The method has also been applied to the synthesis of 3-(trifluoromethyl)salicylic acid.

3-Substituted salicylamides

-

, (2008/06/13)

Novel 3-substituted salicylamides having increased analgesic activity and prolonged analgesic activity are disclosed.

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