350508-38-2

Basic information

• Product Name: (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline;(4R)-4-Methyl-1,2,3,4-Tetrahydroisoquinoline
• CAS NO: 350508-38-2
• Molecular Formula: C10H13N
• Molecular Weight: 147.21692
• Mol File: 350508-38-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline(350508-38-2)
• EPA Substance Registry System: (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline(350508-38-2)

Safety Data

• Hazardous Substances Data: 350508-38-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry Research:
(R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline is utilized as a key compound in organic chemistry research, where it aids in the exploration of novel chemical reactions and the synthesis of new molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline serves as a valuable starting material for the creation of innovative drug candidates. Its unique structure and potential biological activity make it a promising candidate for the development of new medications.
Used in Synthesis of Pharmaceuticals:
(R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline is also employed in the synthesis of various pharmaceuticals, where its structural properties can be leveraged to produce a diverse range of therapeutic agents.
Potential Use in Disease Treatment:
While still under investigation, (R)-4-Methyl-1,2,3,4-tetrahydroisoquinoline may have potential applications in the treatment of diseases and disorders. Further research is necessary to fully understand its pharmacological properties and establish its efficacy in medical treatments.

Upstream product

• 503822-45-5 (1'R,4S)-2-(2'-hydroxy-1'-phenylethyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1492030-94-0 (4R)-2-benzyl-4-methyl-1,2,3,4-tetrahydroisoquinoline 
• 582-22-9 (R)-2-phenylpropylamine 
• 350508-37-1 (1R,2S,5R)-5-Methyl-2-[1-methyl-1-((R)-4-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-cyclohexanol 
• 203190-42-5 N-allyl-2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 203190-45-8 (5R,7aS,10R,11aR,12aS)-5,7,7,10-Tetramethyl-5,7a,8,9,10,11,11a,12a-octahydro-6H,7H-12-oxa-6a-aza-benzo[a]anthracene 
• 334706-50-2 2α-(o-bromophenyl)-4,4,7α-trimethyl-trans-octahydro-1,3-benzoxazine 
• 6630-33-7 ortho-bromobenzaldehyde 
• 503822-36-4 (2R,4R)-3-allyl-2-(2-bromophenyl)-4-phenyl-1,3-oxazolidine 
• 503822-39-7 (3R,6R)-6-methyl-3-phenyl-2,3,6,10b-tetrahydro-5H-oxazolo[2,3-a]isoquinoline 
• 100-39-0 benzyl bromide 
• 60479-65-4 (S)-2-(N,N-dibenzylamino)-1-propanol 
• 60479-64-3 2(R)--1-propanol 

Relevant articles and documents

Iridium-Catalyzed Enantioselective α-C(sp3)-H Borylation of Azacycles

We herein report an iridium-catalyzed enantioselective α-C(sp3)-H borylation of a wide range of azacycles. The combination of an iridium precursor and a chiral bidentate boryl ligand has been shown to effectively differentiate enantiotropic methylene C-H bonds from a single carbon center, affording a variety of synthetically useful azacycles from readily available starting materials with good to excellent enantioselectivities.

Stereoselective and regioselective intramolecular Friedel-Crafts reaction of aziridinium ions for synthesis of 4-substituted tetrahydroisoquinolines

Optically active 4-substituted tetrahydroisoquinolines were synthesized via intramolecular Friedel-Crafts (FC) reactions of aziridinium ions in a highly regio- and stereoselective manner. Control experiments suggest the formation and ring-opening of aziri

Aryl radical cyclization of chiral 3-allyl-2-(2-bromophenyl)-1,3-oxazolidines with tributyltin hydride

Stereoselective radical cyclization of (4R)-3-allyl-2-(2-bromophenyl)-4-phenyl-1,3-oxazolidine promoted by the initiator/tributyltin hydride system constructed the chiral oxazolo[2,3-a]tetrahydroisoquinoline skeleton. These tricyclic compounds were transf

Synthesis of enantiopure mono- and disubstituted tetrahydroisoquinolines by 6-exo radical cyclizations

2-(o-Bromophenyl)-3-allyl- and 2-allyl-3-(o-bromobenzyl)-substituted perhydrobenzoxazines, derived from (-)-8-amino menthol, readily cyclized stereoselectively by reaction with tributyltin hydride in the presence of AIBN. The cyclization compounds were transformed into enantiopure 4-alkyl tetrahydroisoquinolines by reductive ring opening of the N,O-acetal moiety with lithium aluminum hydride. Enantiopure 1,4- and 3,4-dialkyl-substituted tetrahydroisoquinolines were also prepared by reaction of the cyclized compounds with methylmagnesium iodide and subsequent elimination of the menthol appendage.