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Benzenamine, 3,5-difluoro-4-methoxy(9CI), also known as 3,5-Difluoro-4-methoxyaniline, is an organic compound belonging to the class of aniline derivatives. It is characterized by the presence of a fluorine atom at the 3rd and 5th positions, and a methoxy group at the 4th position of the benzene ring. This light brown solid exhibits unique chemical properties that make it suitable for various applications.

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  • 363-47-3 Structure
  • Basic information

    1. Product Name: Benzenamine, 3,5-difluoro-4-methoxy- (9CI)
    2. Synonyms: Benzenamine, 3,5-difluoro-4-methoxy- (9CI);4-AMINO-2,6-FLUOROANISOLE;3,5-Difluoro-4-methoxyaniline;3,5-Difluoro-p-anisidine, 4-Amino-2,6-anisole;4-AMino-2,6-difluoroanisole[3,5-Difluoro-4-Methxoyaniline]
    3. CAS NO:363-47-3
    4. Molecular Formula: C7H7F2NO
    5. Molecular Weight: 159.1333864
    6. EINECS: N/A
    7. Product Categories: HALIDE;Fluorine series
    8. Mol File: 363-47-3.mol
  • Chemical Properties

    1. Melting Point: 77-80℃
    2. Boiling Point: 249.7 °C at 760 mmHg
    3. Flash Point: 104.8 °C
    4. Appearance: /
    5. Density: 1.281 g/cm3
    6. Vapor Pressure: 0.0226mmHg at 25°C
    7. Refractive Index: 1.51
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    9. Solubility: N/A
    10. Water Solubility: Insoluble in water.
    11. CAS DataBase Reference: Benzenamine, 3,5-difluoro-4-methoxy- (9CI)(CAS DataBase Reference)
    12. NIST Chemistry Reference: Benzenamine, 3,5-difluoro-4-methoxy- (9CI)(363-47-3)
    13. EPA Substance Registry System: Benzenamine, 3,5-difluoro-4-methoxy- (9CI)(363-47-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: 6.1
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 363-47-3(Hazardous Substances Data)

363-47-3 Usage

Uses

Used in Chemical Synthesis:
Benzenamine, 3,5-difluoro-4-methoxy(9CI) is used as a key intermediate in the synthesis of various organic compounds, particularly those with pharmaceutical or agrochemical applications. Its unique substitution pattern allows for selective functionalization and the formation of a wide range of derivatives.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzenamine, 3,5-difluoro-4-methoxy(9CI) is used as a building block for the development of novel drugs. Its unique structure and reactivity enable the creation of new molecules with potential therapeutic properties, targeting a variety of diseases and conditions.
Used in Dye and Pigment Industry:
Benzenamine, 3,5-difluoro-4-methoxy(9CI) is also utilized in the dye and pigment industry for the production of high-performance dyes and pigments. Its distinctive chemical structure contributes to the development of dyes with improved color strength, stability, and fastness properties.
Used in conjunction with Thermal Energy:
Benzenamine, 3,5-difluoro-4-methoxy(9CI) is employed in applications that involve the use of thermal energy, such as in the manufacturing of heat-sensitive materials or in thermal energy storage systems. Its unique properties allow for efficient energy transfer and improved performance in these applications.

Check Digit Verification of cas no

The CAS Registry Mumber 363-47-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 363-47:
(5*3)+(4*6)+(3*3)+(2*4)+(1*7)=63
63 % 10 = 3
So 363-47-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H7F2NO/c1-11-7-5(8)2-4(10)3-6(7)9/h2-3H,10H2,1H3

363-47-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,5-Difluoro-4-methoxyaniline

1.2 Other means of identification

Product number -
Other names 3,5-difluoro-4-methoxyaniline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:363-47-3 SDS

363-47-3Relevant articles and documents

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

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Paragraph 0098; 0134; 0135; 0186, (2018/03/25)

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds

Gao, Hongyin,Zhou, Zhe,Kwon, Doo-Hyun,Coombs, James,Jones, Steven,Behnke, Nicole Erin,Ess, Daniel H.,Kürti, László

, p. 681 - 688 (2017/06/30)

Arylmetals are highly valuable carbon nucleophiles that are readily and inexpensively prepared from aryl halides or arenes and widely used on both laboratory and industrial scales to react directly with a wide range of electrophiles. Although C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge because of the absence of suitable heteroatom-transfer reagents. Here, we demonstrate the use of bench-stable N-H and N-alkyl oxaziridines derived from readily available terpenoid scaffolds as efficient multifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl- and heteroarylmetals. This practical and scalable method provides one-step synthetic access to primary anilines and phenols at low temperature and avoids the use of transition-metal catalysts, ligands and additives, nitrogen-protecting groups, excess reagents and harsh workup conditions.

NOVEL FLUORESCENT DYES AND USES THEREOF

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Page/Page column 32-33, (2011/02/24)

The present invention provides fluorescent dyes that are based on firefly luciferin structure. These dyes are optimally excited at shorter wavelengths and have Stokes shift of at least 50 nm. The fluorescent dyes of the invention are useful for preparation of dye-conjugates, which can be used in detection of an analyte in a sample.

Synthesis of COX-2 and FAAH inhibitors

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, (2008/06/13)

Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS

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Page/Page column 40, (2008/06/13)

The present invention relates to diazole derivatives of the general formula (I) wherein A, E, R1, Wand R3 are as defined in the claims and description, their use for the preparation of medicaments for treating diseases and processes

Electrophilic aromatic fluorination with fluorine: meta-Directed fluorination of anilines

Alric,Marquet,Billard,Langlois

, p. 661 - 667 (2007/10/03)

Anilines are mainly or selectively fluorinated in the meta-position with F2 when dissolved in triflic acid, sometimes in the presence of small quantities of antimony pentafluoride. The regioselectivity is increased when an electron-donating substituent is present at the para-position.

2,6-difluorophenol as a bioisostere of a carboxylic acid: Bioisosteric analogues of γ-aminobutyric acid

Qiu, Jian,Stevenson, Scott H.,O'Beirne, Michael J.,Silverman, Richard B.

, p. 329 - 332 (2007/10/03)

3-(Aminomethyl)-2,6-difluorophenol (6) and 4-(aminomethyl)-2,6- difluorophenol (7) were synthesized in eight and four steps, respectively, starting from 2,6-difluorophenol, to test the potential of the 2,6- difluorophenol moiety to act as a lipophilic bio

The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol

Barnard,Storr,O'Neill,Park

, p. 736 - 744 (2007/10/02)

The physicochemical properties and analgesic action of six fluorinated analogues of 4-hydroxyacetanilide (paracetamol) have been investigated. Fluorine substitution adjacent to the hydroxyl group increased lipophilicity and oxidation potential whilst substitution adjacent to the amide had little effect on lipophilicity but led to a greater increase in oxidation potential. Lack of coplanarity and conjugation of the amide group and aromatic ring was also apparent with the analogues that had fluorine in the 2 and 6 positions. Introduction of fluorine into the amide group of paracetamol increased the lipophilicity 4-fold and also increased the oxidation potential of paracetamol. ED50 values for analgesic activity in the phenylquinone-induced abdominal constriction test on male Swiss White mice showed that ring substitution by fluorine reduced activity, especially at the 2,6-positions. Introduction of fluorine into the amide group enhanced activity significantly. Correlation of the analgesic activity with the physicochemical properties indicated that conjugation (and planarity) of the amide group with the aromatic ring is essential for activity and that ease of oxidation may also be an important factor.

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