36881-76-2

Basic information

• Product Name: ASISCHEM W27133
• Synonyms: ASISCHEM W27133;METHYL 2-(METHYL(METHYLSULFONYL)AMINO)BENZOATE;2-(mesyl-methyl-amino)benzoic acid methyl ester;2-(methyl-methylsulfonylamino)benzoic acid methyl ester;MLS000063338;SDCCGMLS-0013536.P002;SMR000075018;ST012303
• CAS NO: 36881-76-2
• Molecular Formula: C₁₀H₁₃NO₄S
• Molecular Weight: 243.28
• Mol File: 36881-76-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ASISCHEM W27133(CAS DataBase Reference)
• NIST Chemistry Reference: ASISCHEM W27133(36881-76-2)
• EPA Substance Registry System: ASISCHEM W27133(36881-76-2)

Safety Data

• Hazardous Substances Data: 36881-76-2(Hazardous Substances Data)

Upstream product

• 716-41-6 methyl N-mesylanthranilate 
• 74-88-4 methyl iodide 
• 74-87-3 methylene chloride 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 36881-68-2 1-methyl-2,2,4-trioxo-1,2,3,4-tetrahydro-2λ⁶-benzo[c][1,2]thiazine-3-carboxylic acid anilide 
• 36881-73-9 1-methyl-2,2,4-trioxo-1,2,3,4-tetrahydro-2λ⁶-benzo[c][1,2]thiazine-3-carboxylic acid 4-methyl-anilide 
• 36881-70-6 1-methyl-2,2,4-trioxo-1,2,3,4-tetrahydro-2λ⁶-benzo[c][1,2]thiazine-3-carboxylic acid 4-bromo-anilide 
• 36881-71-7 1-methyl-2,2,4-trioxo-1,2,3,4-tetrahydro-2λ⁶-benzo[c][1,2]thiazine-3-carboxylic acid 3-chloro-anilide 
• 36881-69-3 4-hydroxy-1-methyl-2,2-dioxo-1,2-dihydro-2λ⁶-benzo[c][1,2]thiazin-3-carboxylic acid 4-methoxyphenylamide 
• 36881-74-0 1-methyl-2,2,4-trioxo-1,2,3,4-tetrahydro-2λ⁶-benzo[c][1,2]thiazine-3-carboxylic acid 2-methoxy-anilide 
• 36881-72-8 1-methyl-2,2,4-trioxo-1,2,3,4-tetrahydro-2λ⁶-benzo[c][1,2]thiazine-3-carboxylic acid 4-nitro-anilide 
• 1088979-71-8 N-(2-(hydroxymethyl)phenyl)-N-methylmethanesulfonamide 

Relevant articles and documents

Synthesis, X-ray crystal and monoamine oxidase inhibitory activity of 4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine 5,5-dioxides: In vitro studies and docking analysis

We report the synthesis and biological evaluation of two new series of 2-amino-6-benzyl-4-phenyl-4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine-3?carbonitrile 5,5-dioxides and 2-amino-6-methyl-4-phenyl-4,6-dihydrobenzo[c]pyrano[2,3-e][1,2]thiazine-3?carbon

4 - hydroxy - 3 - benzoyl - 1 - alkyl - 2, 1 - benzothiazine - 2, 2 - dioxide derivative and application thereof

The invention relates to a 4-hydroxy-3-benzoyl-1-alkyl-2, 1-benzothiazine-2, 2-dioxide derivative and application. The structure general formula of the compound is (I), and R1 and R2 are defined according to the claim. 2-methyl anthranilate is used as raw

4 - hydroxy - 3 - acyl - 1 - alkyl - 2, 1 - benzothiazine - 2, 2 - dioxide derivative and application thereof

The invention relates to a 4-hydroxy-3-acyl-1-alkyl-2,1-benzothiazine-2,2-dioxide ramification and application thereof. The 4-hydroxy-3-acyl-1-alkane-2,1-benzothiazine-2,2-dioxide derivative is obtained through sulfoamidation, alkylation, ring closure and

Discovery of (2-benzoylethen-1-ol)-containing 1,2-benzothiazine derivatives as novel 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting-based herbicide lead compounds

A series of (2-benzoylethen-1-ol)-containing benzothiazine derivatives was synthesized, and their herbicidal activities were first evaluated. The bioassay results indicated that some of 3-benzoyl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide derivatives displayed good herbicidal activity in greenhouse testing, especially, compound 4w had good pre-emergent herbicidal activities against Brassica campestris, Amaranthus retroflexus and Echinochloa crusgalli even at a dosage of 187.5 g ha-1. More importantly, compound 4w displayed significant inhibitory activity against Arabidopsis thaliana HPPD and was identified as the most potent candidate with IC50 value of 0.48 μM, which is better than the commercial herbicide sulctrione (IC50 = 0.53 μM) and comparable with the commercial herbicide mesotrione (IC50 = 0.25 μM). The structure-activity relationships was studied and provided some useful information for improving herbicidal activity. The present work indicated that (2-benzoylethen-1-ol)-containing 1,2-benzothiazine motif could be a potential lead structure for further development of novel HPPD inhibiting-based herbicides.

COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS

The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

New gas-phase cascade reactions of stabilized phosphorus ylides leading to ring-fused indoles and to quinolines

(Chemical Equation Presented) Gas-phase cyclization processes of stabilized phosphorus ylides bearing a suitably substituted 2-aminophenyl group lead efficiently either to 3-substituted quinolines or benzo[c]-carbazole and heterocyclic-fused analogues depending on the substituents present.

4-benzoyl isoxazoles derivatives and their use as herbicides

4-Benzoylisoxazole derivatives of the formula wherein R is H or an ester; R1is alkyl, haloalkyl or optionally substituted cycloalkyl; R2is halogen, optionally halogenated alkyl, alkenyl or alkynyl; alkyl substituted with one or more —OR5; —NO2, —CN, —CO2R5, —S(O)pR6, —O(CH2)mOR5, —COR5, —NR5R6, —N(R8)SOqR7, —CONR9R10or —OR51; or optionally substituted phenyl; R3is —S(O)qR7; X is —N(R8)—; n is 0, 1, 2, 3, or 4; R5, R51and R6are independently H; optionally halogenated alkyl, alkenyl or alkynyl; optionally substituted phenyl; or cycloalkyl; R7is optionally halogenated alkyl, alkenyl or alkynyl; cycloalkyl; optionally substituted phenyl; or optionally substituted amino; R8is H; optionally halogenated alkyl, alkenyl or alkynyl; cycloalkyl; optionally substituted phenyl; or alkoxy; m is 1, 2 or 3; p is 0, 1 or 2; q is 0 or 2; and their use as herbicides are described.