38186-82-2

Basic information

• Product Name: 5-AMINO-2-CHLORO-3-PICOLINE
• Synonyms: 6-CHLORO-5-METHYLPYRIDIN-3-AMINE;6-CHLORO-5-METHYL-PYRIDIN-3-YLAMINE;5-AMINO-2-CHLORO-3-PICOLINE;2-chloro-3-methyl-5-aminopyridine;5-AMINO-2-CHLORO-3-METHYLPYRIDINE;2-CHLORO-5-AMINO-3-PICOLINE;5-Amino-2-chloro-3-picoline ,97%;3-amine-6-chloro-5-methylpyridine
• CAS NO: 38186-82-2
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• Product Categories: Pyridine;pharmacetical;Pyridine series;Amines;Pyridines
• Mol File: 38186-82-2.mol

Chemical Properties

• Melting Point: 90.0 to 94.0 °C
• Boiling Point: 304.689 °C at 760 mmHg
• Flash Point: 138.071 °C
• Appearance: /
• Density: 1.26 g/cm³
• Refractive Index: 1.596
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.06±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-2-CHLORO-3-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-CHLORO-3-PICOLINE(38186-82-2)
• EPA Substance Registry System: 5-AMINO-2-CHLORO-3-PICOLINE(38186-82-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-36/37/38-20/21/22
• Safety Statements: 26-39-36/37/39
• RIDADR: 2811
• WGK Germany: 3
• Hazardous Substances Data: 38186-82-2(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C6H7ClN2/c7-3-6-2-1-5(8)4-9-6/h1-2,4H,3,8H2

Upstream product

• 22280-56-4 2-chloro-3-methyl-5-nitropyridine 
• 7732-18-5 water 
• 7439-89-6 iron 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 108666-35-9 N-(6-Chloro-5-methyl-pyridin-3-yl)-4-fluoro-benzamide 
• 108666-32-6 2-Chloro-N-(6-chloro-5-methyl-pyridin-3-yl)-benzamide 
• 108666-33-7 4-Chloro-N-(6-chloro-5-methyl-pyridin-3-yl)-benzamide 
• 59782-89-7 2-Chloro-5-iodo-3-methylpyridine 
• 37105-10-5 6-chloro-5-methyl-3-pyridinesulfonyl chloride 
• 54232-04-1 6-chloro-5-methylpyridine-3-yl acetate 
• 228867-86-5 5-hydroxy-3-methylpyridine-2-carbonitrile 
• 1624607-04-0 5-((4-methoxybenzyl)oxy)-3-methyl-2-vinylpyridine 
• 1624607-03-9 2-chloro-5-((4-methoxybenzyl)oxy)-3-methylpyridine 
• 54232-03-0 2-chloro-5-hydroxy-3-methylpyridine 
• 74650-77-4 (S)-5-benzyloxy-2-(3-t-butylamino-2-hydroxypropoxy)nicotinonitrile 
• 74650-76-3 5-benzyloxy-2-chloronicotinonitrile 
• 74650-80-9 5-benzyloxy-2-chloro-3-methylpyridine 
• 74650-71-8 2-chloro-5-methoxy-3-pyridinecarboxylic acid 

Relevant articles and documents

CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula (I), independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and 15 deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimers Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

Metal-Free Reduction of Aromatic Nitro Compounds to Aromatic Amines with B2pin2 in Isopropanol

A metal-free reduction of aromatic nitro compounds to the corresponding amines has been achieved by a combination of B2pin2 and KOtBu in isopropanol. A series of nitro compounds containing various reducible functional groups were chemoselectively reduced in good to excellent yields.

Proton pump inhibitors

A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R 1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R 2 , R 3 and R 4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R 5 and R 6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE ABSTRACT OF THE DISCLOSURE The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: {INSERT STRUCTURE HERE} I wherein variables A4, A5, A6, A8, each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

Selective catalytic hydrogenation of nitro groups in the presence of activated heteroaryl halides

Chemoselective reduction of nitro groups in the presence of activated heteroaryl halides was achieved via catalytic hydrogenation with a commercially available sulfided platinum catalyst. The optimized conditions employ low temperature, pressure, and catalyst loading (0.1 mol % Pt) to afford heteroaromatic amines with minimal hydrodehalogenation byproducts.

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

ORGANIC COMPOUNDS

The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6 R7 and R8 are as defined in the specification and in the claims, in free form or in salt form , processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.

PROTON PUMP INHIBITORS

A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

Methyl, trifluoromethyl, and methoxycarbonyl - Introduction to the fifth position on the pyridine ring of chloronicotinyl insecticide imidacloprid

Imidacloprid is the first chloronicotinyl insecticide and is currently the largest-selling insecticide worldwide. As a project to find its variants of different insecticidal spectra, derivatives substituted with methyl, trifluoromethyl, and methoxy-carbonyl at the fifth position on the pyridine ring of imidacloprid were prepared. Copyright Taylor & Francis Group, LLC.