38985-80-7

Basic information

• Product Name: 2-(acetylamino)-5-methoxybenzoic acid
• Synonyms: 2-(acetylamino)-5-methoxybenzoic acid;2-ACETAMIDO-5-METHOXYBENZOIC ACID
• CAS NO: 38985-80-7
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 0
• Mol File: 38985-80-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(acetylamino)-5-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(acetylamino)-5-methoxybenzoic acid(38985-80-7)
• EPA Substance Registry System: 2-(acetylamino)-5-methoxybenzoic acid(38985-80-7)

Safety Data

• Hazardous Substances Data: 38985-80-7(Hazardous Substances Data)

Usage

Classification

Acetylanilides
Belongs to a class of chemical compounds that have a specific structure and common properties.

Appearance

White to off-white crystalline powder
The physical form of the compound, which is a white or off-white crystalline solid.

Molecular weight

223.23 g/mol
The mass of one mole of the compound, which is 223.23 grams.

Use in pharmaceutical industry

Intermediate in the synthesis of various drugs
Acts as a building block or precursor in the production of different pharmaceutical compounds.

Use in production of other organic compounds

As a starting material or reagent
Can be utilized as a base compound to create other organic molecules through chemical reactions.

Application in medicinal chemistry and drug discovery

Structural features and properties
The specific structure and properties of the compound make it a potential candidate for the development of new medications and therapeutic agents.

Upstream product

• 38527-50-3 2-methyl-6-(methoxy)-3,1-benzoxazin-4-one 
• 31601-41-9 N-(4-methoxy-2-methylphenyl)acetamide 
• 201230-82-2 carbon monoxide 
• 79069-37-7 1-(acetamino)-2-bromo-4-methoxybenzene 
• 7487-88-9 magnesium sulfate 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 75-36-5 acetyl chloride 
• 1076-74-0 5-methoxy-2-methyl-1H-indole 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 39495-15-3 4-acetamido-3-methylphenol 
• 1882-76-4 2-acetylamino-5-hydroxy-benzoic acid 
• 77-78-1 dimethyl sulfate 
• 32833-96-8 N,N-dimethyloxamic acid 

Downstream Products

• 6705-03-9 2-Amino-5-methoxybenzoic acid 
• 684237-55-6 2-acetamido-5-methoxy-3-nitrobenzoic acid 
• 172162-02-6 2-amino-5-methoxy-3-nitrobenzoic acid 

Relevant articles and documents

Oxidative Cleavage of Indoles Mediated by Urea Hydrogen Peroxide or H2O2 in Polar Solvents

The oxidative cleavage of indoles (Witkop oxidation) involving the use of H2O2 or urea hydrogen peroxide in combination with a polar solvent has been described. Among these solvents, 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) stands out as the one affording the corresponding 2-ketoacetanilides generally in higher yields The protocol described has also enabled the oxidation of different pyrroles and furans derivatives. Furthermore, the procedure was implemented in a larger-scale and HFIP was distilled from the reaction mixture and reused (up to 4 cycles) without a significant detriment in the reaction outcome, which remarks its sustainability and applicability. (Figure presented.).

BENZIMIDAZOLES DERIVATIVES AS ANTI-TUBERCULOSIS AGENTS

The present invention provides novel compounds of benzimidazole derivatives as anti-tubercular agents and their pharmaceutically acceptable salts for use as bactericidal therapeutics. The invention also provides a pharmaceutical composition comprising a c

Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity

We report a novel benzimidazole (BI) based DprE1 inhibitor that resulted from scaffold morphing of a 1,4-azaindole series. The clinical progression of the 1,4-azaindole series from our previous work validates the potential of exploring newer chemical enti

Synthesis, molecular modeling of N-acyl benzoazetinones and their docking simulation on fungal modeled target

A series of stable N-acyl benzoazetinones have been synthesized in moderate to good yields (58–85%) from easily available substrates such as 2-(N-acyl) amino benzoic acids through intramolecular amidation under mild conditions. These geometry-optimized benzoazetinones were docked in the model target of P450, class CYP53A15, a benzoate 4-monooxygenase abundantly found in the genome of ascomycetes and Basidiomycetes classes of pathogenic fungi. Low per residue root-mean-square deviation (RMSD) of modeled structure of the enzyme indicated similar topology as template (4D6Z.pdb). Observed score judges site-specific docking, and the interaction of quantum mechanically optimized benzoazetinone derivatives with the target enzyme. These results suggest that 3i is the best antifungal agent. The specific hydrophobic substituent in the benzoazetinones contributed to the stability of ligand–target complex. Overall, the study provided insight into the specificity of the site-specific interactions, thereby, facilitating the possibility of development of broad-spectrum antifungal agents against opportunistic and infectious fungi.

Palladium-catalyzed C-H bond carboxylation of acetanilides: An efficient usage of N,N-dimethyloxamic acid as the carboxylate source

N,N-Dimethyloxamic acid can be successfully employed as a carboxylate precursor in the palladium-catalyzed direct C-H carboxylation of acetanilides. The reaction proceeds smoothly under mild conditions over a broad range of substrates with high functional group tolerance, affording substituted N-acyl anthranilic acids in moderate to high yields.

ONE-POT REDUCTIVE ACETAMIDATION OF ARYL NITRO COMPOUNDS

The present invention provides a method for the reductive acetamidation of an aryl nitro compound by reacting a substituted acid with an aryl nitro compound and adding a catalytic amount of a base with the substituted acid and the aryl nitro compound to form an acetamidation aryl nitro compound. The acetamidation aryl nitro compound is then purified.