39095-38-0

Basic information

• Product Name: Corey-Kim reagent
• Synonyms: Corey-Kim reagent;N-Chlorosuccinimide-Dimethyl Sulfide
• CAS NO: 39095-38-0
• Molecular Formula: C₆H₁₀NO₂S*Cl
• Molecular Weight: 195.6671
• Mol File: 39095-38-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Corey-Kim reagent(CAS DataBase Reference)
• NIST Chemistry Reference: Corey-Kim reagent(39095-38-0)
• EPA Substance Registry System: Corey-Kim reagent(39095-38-0)

Safety Data

• Hazardous Substances Data: 39095-38-0(Hazardous Substances Data)

Upstream product

• 128-09-6 N-chloro-succinimide 
• 75-18-3 dimethylsulfide 

Downstream Products

• 65739-17-5 2,3-Dicyano-2-(3-cyano-2-methoxycarbonyl-3,3-diphenyl-propenylideneamino)-3,3-diphenyl-propionic acid methyl ester 
• 82650-36-0 3-Cyano-2-(methylsulfanylmethylimino-methylene)-3,3-diphenyl-propionic acid methyl ester 
• 82650-37-1 2,3-Dicyano-2-methylsulfanylmethyl-3,3-diphenyl-propionic acid methyl ester 
• 2373-51-5 chloro-methylsulfanyl-methane 
• 123-56-8 Succinimide 
• 184166-40-3 1-(3,4-Dimethoxy-phenyl)-3-(dimethyl-λ⁴-sulfanylidene)-5-phenyl-pentane-2,4-dione 
• 184166-39-0 3-(Dimethyl-λ⁴-sulfanylidene)-1-(4-methoxy-phenyl)-5-phenyl-pentane-2,4-dione 
• 184166-38-9 3-(Dimethyl-λ⁴-sulfanylidene)-1-(2-methoxy-phenyl)-5-phenyl-pentane-2,4-dione 
• 161152-05-2 dimethylsulfonium 1-(phenylacetyl)-2-oxo-3-(pentafluorohenyl)propylide 
• 161152-04-1 3-(dimethyl-λ4-sulfanylidene)-1,5-diphenyl-pentane-2,4-dione 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 33313-98-3 2,6,6-tris(methylthiomethyl)-2,4-cyclohexadien-1-one 
• 15021-43-9 dimethylsulfonium 1-benzoyl-2-oxopropylide 
• 10353-20-5 2,6-bis(methylthiomethyl)-4,6-dimethyl-2,4-cyclohexadien-1-one 

Relevant articles and documents

Synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-, 3'- and 4'-positions of the rhamnose moiety

In an effort to increase the insecticidal activity of the spinosyn family of naturally occurring macrolides, the 2'-, 3'- and 4'-O-desmethyl-O-acetyl analogs and the 2'-, 3'-, and 4'-O-desmethoxy analogs have been synthesized. These analogs were prepared synthetically from the minor spinosyn factors H, J, K, L and Q either via direct acylation of the corresponding factor or deoxygenation of an intermediate xanthate. The acylated analogs were all more potent insecticides against Heliothis virescens larvae than their respective parent factors, but not as potent as spinosyns A or D. The deoxy analogs were also more potent insecticides than their respective parent factors. The 2'-desmethoxy analogs showed, for the first time, analogs with insecticidal potency against H. virescens greater than that of spinosyns A and D, indicating that polarity is not well tolerated in the rhamnose moiety of spinosyn A.

ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION

Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2'-diindolylmethane, 2',3-diindolylmethane, and 3,3'-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

Synthesis of 1-hydroxybicyclo[3.2.1]oct-3-en-2-ones by Acyloin rearrangement of 1-methoxy- or 1-tert-butyldimethylsilyloxybicyclo [2.2.2] oct-5-en-2-ones

1-Hydroxy-or 1,8-dihydroxy-bicyclo[3,2,1]oct-3-en-2-ones were obtained from 1-methoxy- or 1-tert-butyldimethylsilyloxy-bicyclo[2,2,2]oct-5-en-2- ones via successive processes involving demethylation or desilylation and acyloin rearrangement by reaction wi

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Donor substituted sulfonyl carbenes, 2: Organothio sulfonyl carbenes

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Convenient synthesis of 2,4-cyclohexadien-1-ones by regioselective methylthiomethylation of phenols

A convenient synthesis of a variety of 2,4-cyclohexadien-1-ones 3-7 is deseribed. Reaction of various phenols 2 having appropriate substituents with an excess of S,S-dimethylsuccinimidosulfonium chloride (Corey-Kim reagent, 1) in the presence of triethyla

Convenient Synthesis of Sulfur Ylides by Reaction of Active Methylene Compounds with Corey-Kim Reagent

Reactions of active methylene compounds with Corey-Kim reagent in the presence of triethylamine afford stable sulfur ylides in satisfactory yields.

INDOLE- AND PYRROLE-SULFONIUM YLIDES

Electrophilic substitution of indole and pyrrole with sulfoxides and acid anhydrides leads to the formation of indole-3-sulfonium salts and pyrrole-2-sulfonium salts.These are deprotonated with potassium carbonate to give indole-3-sulfonium ylides and pyr

Synthesis of 1,3-Dicarbonyl Compounds by the Oxidation of 3-Hydroxycarbonyl Compounds with Corey-Kim Reagent

A new method for the preparation of various 1,3-dicarbonyl compounds is described.Oxidation of 3-hydroxycarbonyl compounds without substituent at C-2 position by the Corey-Kim reagent (N-chlorosuccinimide-dimethyl sulfide) afforded the stable dimethylsulfonium methylides, which on reductive desulfurization by zinc-acetic acid furnished the 1,3-dicarbonyl derivatives.On the other hand, the same treatment of 2-mono-, or 2,2-disubstituted 3-hydroxy-carbonyl compounds gave directly the corresponding 1,3-dicarbonyl analogous, respectively.