398497-81-9

Basic information

• Product Name: 2-FE-BETA-CIT
• Synonyms: 3-(4-IODO-PHENYL)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID 2-FLUORO-ETHYL ESTER;2-FE-BETA-CIT;2-FLUORETHYL;2-FLUORETHYL-BETA-CIT;8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 3-(4-IODOPHENYL)-8-METHYL-, 2-FLUOROETHYL ESTER, (1R,2S,3S,5S)-;3beta-(4''-iodophenyl)tropan-2beta-carboxylic acid, 2-fluoro-ethyl ester
• CAS NO: 398497-81-9
• Molecular Formula: C₁₇H₂₁FINO₂
• Molecular Weight: 417.26
• Mol File: 398497-81-9.mol

Chemical Properties

• Boiling Point: 461.6 °C at 760 mmHg
• Flash Point: 233 °C
• Appearance: /
• Density: 1.484 g/cm³
• Water Solubility: at 25 deg C (mg/L): 1.876
• CAS DataBase Reference: 2-FE-BETA-CIT(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FE-BETA-CIT(398497-81-9)
• EPA Substance Registry System: 2-FE-BETA-CIT(398497-81-9)

Safety Data

• Hazardous Substances Data: 398497-81-9(Hazardous Substances Data)

Upstream product

• 371-62-0 2-fluoroethanol 
• 180057-11-8 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carbonyl chloride 
• 50373-10-9 methyl ecgonidine 
• 174224-35-2 2β-carbomethoxy-3β-(4'-trimethylsilylphenyl)tropane 
• 17878-43-2 [4-(trimethylsilyl)phenyl]magnesium bromide 
• 141807-58-1 RTI 102 
• 135416-43-2 (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents

A series of novel fluoroalkyl-containing tropane derivatives were synthesized from cocaine. The binding affinities for DAT, SERT, and NET were determined via competitive binding assays. A series of novel fluoroalkyl-containing tropane derivatives (6-8, 10

Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: Potential positron emission tomography (PET) imaging agents for the dopamine transporter

A series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET) were determined via competitive binding assays. Among these derivatives, the fluoropropyl ester of β-CIT (19), the fluoroethyl ester of β-CIT (20), the N-fluoropropyl derivative of β-CBT (12), and the fluoropropyl ester of β-CMT (18) displayed higher affinity and greater selectivity for the DAT versus SERT and NET than FP-CIT, which indicates that they are attractive candidates for the development of 18F-labeled PET imaging agents for the DAT.