40525-78-8

Basic information

• Product Name: 4α-Aminocyclohexan-1α-ol
• Synonyms: cis-4-Aminocyclohexanol;Cis-aminohexanol;Ambroxol Impurity 6
• CAS NO: 40525-78-8
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• EINECS: 1308068-626-2
• Mol File: 40525-78-8.mol

Chemical Properties

• Boiling Point: 75.4 °C
• Appearance: /
• Density: 1.037
• PKA: 15.12±0.40(Predicted)
• CAS DataBase Reference: 4α-Aminocyclohexan-1α-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4α-Aminocyclohexan-1α-ol(40525-78-8)
• EPA Substance Registry System: 4α-Aminocyclohexan-1α-ol(40525-78-8)

Safety Data

• RIDADR: UN1993
• Hazardous Substances Data: 40525-78-8(Hazardous Substances Data)

Usage

Uses

Used in Research and Development:
4α-Aminocyclohexan-1α-ol is used as a key component in organic synthesis and medicinal chemistry for its unique chemical properties and reactivity, contributing to the advancement of scientific knowledge and the creation of novel compounds.
Used in Pharmaceutical Industry:
4α-Aminocyclohexan-1α-ol is used as a precursor in the development of new drugs and medications due to its ability to interact with biological systems, playing a crucial role in the formulation of innovative therapeutic agents.
Used in Material Science:
4α-Aminocyclohexan-1α-ol is utilized in the development of new materials and technologies, leveraging its unique chemical properties to enhance or create materials with specific characteristics for various applications.

InChI:InChI=1S/C6H13NO/c7-5-1-3-6(8)4-2-5/h5-6,8H,1-4,7H2

Upstream product

• 100-02-7 4-nitro-phenol 
• 27489-61-8 cis-(N-4-hydroxycyclohexyl)acetamide 
• 123-30-8 4-amino-phenol 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 103-90-2 4-acetaminophenol 
• 123-31-9 hydroquinone 

Downstream Products

• 64979-91-5 cis-(4-hydroxycyclohexyl)-1H-benz[de]isoquinoline-1,3-(2H)-dione 
• 1237716-69-6 N-((1s,4s)-4-hydroxycyclohexyl)-4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)-phenyl)isoxazole-3-carboxamide 
• 1384114-17-3 C₁₉H₂₀N₄O₅S 
• 1384114-32-2 C₁₉H₂₂N₄O₃S 
• 1418199-14-0 cis-4-(2-((R)-1-hydroxyethyl)imidazo[4,5-d]pyrrolo[2,3-b]-pyridin-1(6H)-yl)cyclohexanol 
• 1440422-31-0 C₂₂H₂₄N₄O₄S 
• 167081-25-6 cis-(4-hydroxycyclohexyl)carbamic acid tert-butyl ester 
• 223605-18-3 (1s,4s)-4-(piperazin-1-yl)cyclohexanol 
• 1374215-13-0 ethyl 6-chloro-4-(((1s,4s)-4-hydroxycyclohexyl)amino)nicotinate 

Relevant articles and documents

The Rhodium Catalysed Direct Conversion of Phenols to Primary Cyclohexylamines

Cyclohexylamines are important intermediates in chemical industry, which are currently produced from petrochemical sources. Phenols, however, are an attractive sustainable feedstock. We here demonstrate the transformation of phenols with ammonia to primary cyclohexylamines. In contrast to previously reported chemistry which used palladium catalysts, we here show that rhodium is an excellent catalyst for the formation of primary cyclohexylamines. Different parameters were studied and it was shown that the reaction is applicable to a scope of phenolic compounds providing high selectivity.