421-06-7

Basic information

• Product Name: 2-BROMO-1,1,1-TRIFLUOROETHANE
• Synonyms: 1,1,1-trifluoro-2-bromoethane;2-Brom-1,1,1-trifluorethan;2-bromo-1,1,1-trifluoro-ethan;Ethane, 2-bromo-1,1,1-trifluoro-;ethane,2-bromo-1,1,1-trifluoro-;HBFC133ab1;1-Bromo-2,2,2-trifluoroethane (FC-133aB1);2-BROMO-1,1,1-TRIFLUOROETHANE (HCFC-133AB1)
• CAS NO: 421-06-7
• Molecular Formula: C₂H₂BrF₃
• Molecular Weight: 162.94
• EINECS: 207-001-7
• Mol File: 421-06-7.mol

Chemical Properties

• Melting Point: -94°C
• Boiling Point: 26°C
• Flash Point: -59℃
• Appearance: /
• Density: 1.788 g/mL at 25 °C(lit.)
• Vapor Pressure: 772mmHg at 25°C
• Refractive Index: 1.333
• CAS DataBase Reference: 2-BROMO-1,1,1-TRIFLUOROETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1,1,1-TRIFLUOROETHANE(421-06-7)
• EPA Substance Registry System: 2-BROMO-1,1,1-TRIFLUOROETHANE(421-06-7)

Safety Data

• Hazard Codes: Xi,N
• Statements: 21/22-36/38-59-36/37/38
• Safety Statements: 26-36/37/39-59
• RIDADR: 2810
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 421-06-7(Hazardous Substances Data)

Usage

Purification Methods

Wash it with water, dry (CaCl2) and distil it. [Beilstein 1 III 179, 1 IV 154.]

InChI:InChI=1/C2H2BrF3/c3-1-2(4,5)6/h1H2

Upstream product

• 75-81-0 1,2-dibromo-2,2-dichloroethane 
• 420-46-2 2,2,2-trifluoroethanol 
• 359-08-0 2-bromo-1,1-difluoroethene 
• 5870-61-1 2-bromo-1,1-dichloroethylene 
• 339-48-0 2,2,2-trifluoroethyl benzenesulfonate 
• 79-08-3 bromoacetic acid 
• 354-48-3 1,1,1-tribromotrifluoroethane 
• 117113-33-4 3-bromo-3-(trifluoromethyl)diazirine 
• 75-89-8 2,2,2-trifluoroethanol 
• 7789-69-7 phosphorus pentabromide 
• 7664-39-3 hydrogen fluoride 
• 7647-18-9 antimonypentachloride 
• 7783-56-4 antimony(III) fluoride 
• 359-19-3 1,1-dibromo-2,2-difluoroethane 

Downstream Products

• 354-50-7 1-bromo-1,1-dichloro-2,2,2-trifluoro-ethane 
• 753-90-2 trifluoroethylamine 
• 151-67-7 1,1,1-trifluoro-2-bromo-2-chloroethane 
• 405-00-5 3-methyl-N-(2,2,2-trifluoroethyl)aniline 
• 2262-07-9 2,2,2-trifluoroethyl phenyl sulfide 
• 99793-37-0 1,5-Bis-(4-fluoro-phenyl)-3-(2,2,2-trifluoro-ethylsulfanyl)-1H-[1,2,4]triazole 
• 99793-36-9 1-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3-(2,2,2-trifluoro-ethylsulfanyl)-1H-[1,2,4]triazole 
• 115865-39-9 5-(4-Chloro-phenyl)-1-(4-fluoro-phenyl)-3-(2,2,2-trifluoro-ethylsulfanyl)-1H-[1,2,4]triazole 
• 333-36-8 1,1,1-trifluoro-2-(2,2,2-trifluoroethoxy)ethane 
• 598-73-2 1-bromo-1,2,2-trifluoroethene 
• 77745-02-9 Sodium; 2,2,2-trifluoro-ethanesulfonate 
• 76305-00-5 4,4,4-trifluoro-1-(4-methoxyphenyl)-2-phenyl-1-butanone 
• 566913-62-0 (Z)-[3,5-di-iso-propyl-2-(2,2,2-trifluoroethoxyphenyl)]but-2-en-1-ol 
• 566913-63-1 (Z)-[3,5-di-tert-butyl-2-(2,2,2-trifluoroethoxy)phenyl]but-2-en-1-ol 

Relevant articles and documents

Deoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives

A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids is developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers.

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