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2-(2-Amino-phenoxy)-ethanol, also known as Aminoethoxyphenol, is a chemical compound with the molecular formula C8H11NO2. It is an amino alcohol that has a phenolic structure and is soluble in water. 2-(2-Amino-phenoxy)-ethanol is commonly used as a raw material in the production of pharmaceuticals, insecticides, and dyes. It possesses antioxidant properties and is being studied for its potential use in various medicinal applications. However, it is important to use caution when handling this chemical, as it can be harmful if ingested, inhaled, or comes into contact with the skin.

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  • 42876-07-3 Structure
  • Basic information

    1. Product Name: 2-(2-Amino-phenoxy)-ethanol
    2. Synonyms: 2-(2-Amino-phenoxy)-ethanol;Ethanol, 2-(2-aminophenoxy)-
    3. CAS NO:42876-07-3
    4. Molecular Formula: C8H11NO2
    5. Molecular Weight: 153.18
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 42876-07-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(2-Amino-phenoxy)-ethanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(2-Amino-phenoxy)-ethanol(42876-07-3)
    11. EPA Substance Registry System: 2-(2-Amino-phenoxy)-ethanol(42876-07-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 42876-07-3(Hazardous Substances Data)

42876-07-3 Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Amino-phenoxy)-ethanol is used as a raw material for the production of pharmaceuticals for its versatile chemical properties and potential medicinal applications.
Used in Insecticide Production:
2-(2-Amino-phenoxy)-ethanol is used as a component in the manufacturing of insecticides, contributing to the development of effective pest control solutions.
Used in Dye Industry:
2-(2-Amino-phenoxy)-ethanol is used as a raw material in the production of dyes, owing to its chemical structure that can impart color to various substances.
Used in Antioxidant Applications:
The antioxidant properties of 2-(2-Amino-phenoxy)-ethanol make it a candidate for use in applications requiring protection against oxidative stress or damage.

Check Digit Verification of cas no

The CAS Registry Mumber 42876-07-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,8,7 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 42876-07:
(7*4)+(6*2)+(5*8)+(4*7)+(3*6)+(2*0)+(1*7)=133
133 % 10 = 3
So 42876-07-3 is a valid CAS Registry Number.

42876-07-3Relevant articles and documents

Copper nanoparticles (CuNPs) catalyzed chemoselective reduction of nitroarenes in aqueous medium

Chand, Dillip Kumar,Rai, Randhir

, (2021/08/20)

Abstract: A procedure for practical synthesis of CuNPs from CuSO4·5H2O is established, under appropriate reaction conditions, using rice (Oryza sativa) as an economic source of reducing as well as a stabilizing agent. Optical and microscopic techniques are employed for the characterization of the synthesized CuNPs and the sizes of the particles were found to be in the range of 8 ± 2 nm. The nanoparticles are used as a catalyst for chemoselective reduction of aromatic nitro compounds to corresponding amines under ambient conditions and water as a reaction medium. Graphic abstract: CuNPs are synthesized using hydrolysed rice and used as catalyst for chemoselective reduction of nitroarenes to their corresponding amines in water. [Figure not available: see fulltext.]

Compound or pharmaceutically acceptable salt thereof, and application thereof

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Paragraph 0087; 0089; 0093; 0094, (2019/02/04)

The invention provides a compound having a formula I or a pharmaceutically acceptable salt thereof, and a preparation method thereof. The invention also provides application of the compound having theformula I or the pharmaceutically acceptable salt there

Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination

Munnuri, Sailu,Anugu, Raghunath Reddy,Falck, John R.

supporting information, p. 1926 - 1929 (2019/03/11)

Cu(II)-mediated direct NH2 and NH alkyl aryl aminations and olefin aziridinations are described. These room-temperature, one-pot, environmentally friendly procedures replace costly Rh2 catalysts and, in some instances, display important differences with comparable Rh2- and Fe-supported reactions.

Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists

Nitta, Aiko,Iura, Yosuke,Inoue, Hideki,Imaoka, Takayuki,Takahashi, Toshiya,Sato, Ippei,Morihira, Koichiro,Kubota, Hirokazu,Morokata, Tatsuaki,Takeuchi, Makoto,Ohta, Mitsuaki,Tsukamoto, Shin-Ichi

, p. 6876 - 6881,6 (2020/09/02)

Optimization starting with our lead compound 1 (IC50 = 4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward improvement of the bioavailability provided (R)-1-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-3-(2-(2- hydroxyethoxy)phenyl)urea 32 (IC50 = 1.7 nM), a potent and orally active CCR3 antagonist.

Synthesis and characterization of selected 4,4′-diaminoalkoxyazobenzenes

Jeong, Euigyung,Freeman, Harold S.,Claxton, Larry D.

experimental part, p. 100 - 108 (2010/12/18)

The role of the -N(CH2CH2OH)2 group in producing a mutagenic response from 4-((3-(2-hydroxyethoxy)4-amino)phenylazo)-N,N-bis(2-hydroxyethyl)aniline has been investigated. To accomplish this goal, a group of substituted 4,4′-diaminoazobenzene dyes was synthesized, and their structures were confirmed using 1H NMR, TOF-LC-ESI mass spectrometry, and combustion analysis. Mutagenicity was determined using the standard Ames test in Salmonella strains TA98, TA100, and TA1538 with and without S9 enzyme activation. The results of this study provide evidence that the mutagenicity of the parent dye arises from the metabolic cleavage of N-hydroxyethyl groups to give the corresponding -NHCH2CH2OH and -NH2 substituted monoazo dyes as direct-acting mutagens. All 5 of the dyes studied were mutagenic at various levels with and without S9 enzyme activation in TA1538. In addition, the results show that removing one N-hydroxyethyl group and capping both -OH groups in the parent dye did not affect mutagenicity, whereas removing both N-hydroxyethyl groups produced a strong direct-acting mutagen in all three bacterial strains. Increasing the length of the N-alkyl chain from two to three carbon atoms eliminated mutagenicity in TA98 without S9 activation.

PIGMENT DISPERSIONS WITH POLYMERIC DISPERSANTS HAVING PENDING CHROMOPHORE GROUPS

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Page/Page column 40, (2010/11/25)

A pigment dispersion comprising a colour pigment and a polymeric dispersant having at least one pending chromophore group covalently bound to the polymeric backbone of the polymeric dispersant through a linking group wherein the colour pigment is selected from the group consisting of monoazo pigments, disazo pigments, β-naphtol pigments, naphtol AS pigments, azo pigment lakes, benzimidazolone pigments, disazo condensation pigments, metal complex pigments, isoindolinone pigments, isoindolinine pigments, phthalocyanine pigments, quinacridone pigments, diketopyrrolo-pyrrole pigments, thioindigo pigments, anthraquinone pigments, anthrapyrimidine pigments, indanthrone pigments, flavanthrone pigments, pyranthrone pigments, anthanthrone pigments, isoviolanthrone pigments, aluminium pigment lakes, dioxazine pigments, triarylcarbonium pigments and quinophthalone pigments; the at least one pending chromophore group has a molecular weight which is smaller than 85 % of the molecular weight of the colour pigment; the at least one pending chromophore group occurs as a side group on the polymeric backbone and not as a group in the polymeric backbone itself or occurring solely as an end group of the polymeric backbone; the linking group consists of all the atoms between the polymeric backbone and the first atom of the aromatic group by which the pending chromophore group is linked to the polymeric backbone; and the at least one pending chromophore group has a similarity coefficient SIM of at least 0.75, with the similarity coefficient defined by (I) wherein, M represents the number of atoms in the at least one pending chromophore group; P represents the number of atoms in the colour pigment; C represents the largest number of atoms in common between the at least one pending chromophore group and the colour pigment as one continuous structure; and t is an integer representing the number of times that the largest number of atoms in common C fits into the organic colour pigment, without using atoms of the colour pigment twice. A method for preparing the pigment dispersion wherein the polymeric dispersant is prepared by copolymerizing a monomer already containing the pending chromophore group is also disclosed.

PIGMENT DISPERSIONS WITH POYMERIC DISPERSANTS HAVING PENDING CHROMOPHORE GROUPS

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Page/Page column 38, (2010/11/25)

A pigment dispersion comprising a colour pigment represented by formula (I) wherein, X1 to X4 are independently selected from the group consisting of hydrogen and a halogen atom, R1 to R10 are independently selected from the group consisting of hydrogen, a halogen atom, a methyl group, an ethyl group, a methoxy group, and an ethoxy group, and a polymeric dispersant having via a linking group covalently linked to its polymeric backbone at least one pending chromophore group which has a molecular weight smaller than 90% of the molecular weight of the colour pigment, wherein the at least one pending chromophore group is a chromophore group occurring as a side group on the polymeric backbone and not a group in the polymeric backbone itself or occurring solely as an end group of the polymeric backbone, and the at least one pending chromophore group is represented by formula (II) wherein, one of L1, L2 or L3 is the linking group and is selected from the group consisting of an aliphatic group, a substituted aliphatic group, an unsaturated aliphatic group and a substituted unsaturated aliphatic group; L1, L2 and/or L3, if not representing the linking group, are independently selected from the group consisting of hydrogen, an alkyl group, an alkenyl group, an alkoxy group, a carboxylic acid group, an ester group, an acyl group, a nitro group and a halogen; AR1 and AR2 represent an aromatic group; and n represents the integer 0 or 1. The pigment dispersion can be advantageously used in inkjet inks. Also disclosed are methods for preparing the inkjet ink.

PIGMENT DISPERSIONS WITH POLYMERIC DISPERSANTS HAVING PENDING CHROMOPHORE GROUPS.

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Page/Page column 42-43, (2010/11/25)

A pigment dispersion comprising a colour pigment represented by formula (I) wherein, R1 is selected from the group consisting of hydrogen, a halogen atom, a methyl group, an ethyl group, a methoxy group, an ethoxy group, -CF3 , -COOH, -COOCH3 and; R2, R4 and R5 are independently selected from the group consisting of hydrogen, a halogen atom, a methyl group, an ethyl group, a methoxy group, an ethoxy group,-CF3 , -COOH and -COOCH3; R3 is selected from the group consisting of hydrogen, a halogen atom, a methyl group, an ethyl group, a methoxy group, an ethoxy group,-CF3, -COOH, -COOCH3, -SO2NH-C6H5, -CONH-C6H5, -CONH-C6H5-CONH2 and -CONH2 ; R6 and R7 are independently selected from the group consisting of hydrogen, a halogen atom, a methyl group, an ethyl group, a methoxy group, an ethoxy group,- CF3 , -COOH and -COOCH3, or R6 and R7 represent the necessary atoms to form an imidazolone ring; and a polymeric dispersant having via a linking group covalently linked to its polymeric backbone at least one pending chromophore group which has a molecular weight smaller than 95% of the molecular weight of said colour pigment. The pigment dispersion can be advantageously used in inkjet inks.

PIGMENT DISPERSIONS WITH POLYMERIC DISPERSANTS HAVING PENDING CHROMOPHORE GROUPS.

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Page/Page column 37-38, (2010/11/25)

A pigment dispersion comprising a colour pigment represented by formula (I) wherein, R1 to R10 are independently selected from the group consisting of hydrogen, a halogen atom, a methyl group, an ethyl group, a methoxy group, an ethoxy group, - CF3 , -COOH, -COOCH3; -SO2NH-C6H5, -CONH-C6H5, -CONH-C6H5-CONH2 and -CONH2; and a polymeric dispersant having via a linking group covalently linked to its polymeric backbone at least one pending chromophore group which has a molecular weight smaller than 95% of the molecular weight of said colour pigment. The pigment dispersion can be advantageously used in inkjet inks.

PIGMENT DISPERSIONS WITH POLYMERIC DISPERSANTS HAVING PENDING CHROMOPHORE GROUPS.

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Page/Page column 39-40, (2010/11/25)

A pigment dispersion comprising a colour pigment and a polymeric dispersant having at least one pending chromophore group covalently bound to the polymeric backbone of the polymeric dispersant through a linking group wherein the at least one pending chromophore group is a derivative from a colour pigment selected from the group consisting of monoazo pigments, disazo pigments, β-naphtol pigments, naphtol AS pigments, azo pigment lakes, benzimidazolone pigments, disazo condensation pigments, metal complex pigments, isoindolinone pigments, isoindolinine pigments, phthalocyanine pigments, quinacridone pigments, diketopyrrolo-pyrrole pigments, thioindigo pigments, anthraquinone pigments, anthrapyrimidine pigments, indanthrone pigments, flavanthrone pigments, pyranthrone pigments, anthanthrone pigments, isoviolanthrone pigments, aluminium pigment lakes, dioxazine pigments, triarylcarbonium pigments and quinophthalone pigments; the at least one pending chromophore group is a chromophore group occurring as a side group on the polymeric backbone and not a group in the polymeric backbone itself or occurring solely as an end group of the polymeric backbone; the linking group consists of all the atoms between the polymeric backbone and the first atom of the aromatic group by which the pending chromophore group is linked to the polymeric backbone; the polymeric dispersant has a polymeric backbone with a polymerization degree between 5 and 1000; and at most 30 % of the monomer units of the polymeric backbone have a pending chromophore group. The pigment dispersion can be advantageously used in inkjet inks. Also disclosed is a method for preparing the pigment dispersion comprising the step of preparing the polymeric dispersant by copolymerizing a monomer already containing the pending chromophore group.

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