4387-16-0

Basic information

• Product Name: BIS(TRIMETHYLSILYL)BISPHENOL A
• Synonyms: 2,2-Bis(4'-trimethylsiloxyphenyl)propane;2,2-Bis[(4-trimethylsiloxy)phenyl]propane;2,2-Bis[(4-trimethylsilyloxy)phenyl]propane;Trimethyl[4-(1-methyl-1-(4-[(trimethylsilyl)oxy]phenyl)ethyl)phenoxy]silane;BIS(TRIMETHYLSILYL)BISPHENOL A
• CAS NO: 4387-16-0
• Molecular Formula: C₂₁H₃₂O₂Si₂
• Molecular Weight: 372.65
• Mol File: 4387-16-0.mol

Chemical Properties

• Boiling Point: 179°C 1,5mm
• Flash Point: 155.9°C
• Appearance: /
• Density: 0.959g/cm³
• Vapor Pressure: 1.09E-05mmHg at 25°C
• Refractive Index: 1.5178
• CAS DataBase Reference: BIS(TRIMETHYLSILYL)BISPHENOL A(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(TRIMETHYLSILYL)BISPHENOL A(4387-16-0)
• EPA Substance Registry System: BIS(TRIMETHYLSILYL)BISPHENOL A(4387-16-0)

Safety Data

• TSCA: No
• Hazardous Substances Data: 4387-16-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
BIS(TRIMETHYLSILYL)BISPHENOL A is used as a precursor in the synthesis of various organic compounds due to its protected hydroxyl groups, which can be selectively deprotected when needed for further reactions.
Used in Polymer Production:
In the Polymer Industry, BIS(TRIMETHYLSILYL)BISPHENOL A is used as a starting material for the production of polycarbonate plastics and epoxy resins. The silyl protection allows for controlled polymerization processes, ensuring the quality and properties of the final polymer products.
Used in Pharmaceutical Industry:
BIS(TRIMETHYLSILYL)BISPHENOL A is used as an intermediate in the synthesis of pharmaceutical compounds. Its stability and reactivity control make it suitable for creating complex organic molecules with specific therapeutic properties.
Used in Chemical Reactions as a Protective Agent:
In the field of organic chemistry, BIS(TRIMETHYLSILYL)BISPHENOL A is used to protect hydroxyl groups during reactions that could otherwise modify or damage these functional groups. This protection allows chemists to perform reactions without unwanted side effects on the hydroxyl groups, and then selectively remove the protecting groups when necessary.

InChI:InChI=1/C21H32O2Si2/c1-21(2,17-9-13-19(14-10-17)22-24(3,4)5)18-11-15-20(16-12-18)23-25(6,7)8/h9-16H,1-8H3

Upstream product

• 80-05-7 BPA 
• 75-77-4 chloro-trimethyl-silane 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 10416-58-7 N,N-bis(trimethylsilyl)acetamide 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 25561-30-2 N,O-Bis(trimethylsilyl)trifluoroacetamide 

Downstream Products

• 80-05-7 BPA 
• 33073-28-8 2,2-Bis-(4-perfluorbutylsulfonyloxy-phenyl)-propan 

Relevant articles and documents

Assessment of Exposure to Di (2-ethylhexyl) Phthalate (DEHP) Metabolites and Bisphenol A (BPA) and Its Importance for the Prevention of Cardiometabolic Diseases

Exposomics analyses have highlighted the importance of biomonitoring of human exposure to pollutants, even non-persistent, for the prevention of non-communicable diseases such as obesity, diabetes, non-alcoholic fatty liver disease, atherosclerosis, and cardiovascular diseases. Phthalates and bisphenol A (BPA) are endocrine disrupting chemicals (EDCs) widely used in industry and in a large range of daily life products that increase the risk of endocrine and cardiometabolic diseases especially if the exposure starts during childhood. Thus, biomonitoring of exposure to these compounds is important not only in adulthood but also in childhood. This was the goal of the LIFE-PERSUADED project that measured the exposure to phthalates (DEHP metabolites, MEHP, MEHHP, MEOHP) and BPA in Italian mother–children couples of different ages. In this paper we describe the method that was set up for the LIFE PERSUADED project and validated during the proficiency test (ICI/EQUAS) showing that accurate determination of urinary phthalates and BPA can be achieved starting from small sample size (0.5 mL) using two MS techniques applied in cascade on the same deconjugated matrix.

Nano Fe3O4@ZrO2/SO42?: A highly efficient catalyst for the protection and deprotection of hydroxyl groups using HMDS under solvent-free condition

In this work, we introduce a new procedure for the protection and deprotection process of various types of alcohols and phenols by HMDS in the presence of nano magnetic sulfated zirconia (Fe3O4@ZrO2/SO42?) as a solid acid catalyst under very mild and solvent-free condition. This method has interesting advantages like short reaction times and a simple workup process. With regard to some outstanding benefits of this new heterogeneous catalyst such as excellent yield, reusability of the catalyst and easy thermal stability, high acidity, strong and excellent magnetic properties, this method can be very interesting in aspect of green chemistry Principles.

Multicyclic poly(ether ketone)s obtained by polycondensation of 2,6,4′-Trifluorobenzophenone with various diphenols

2,6,4′-Trifluorobenzophenone (TFB) was polycondensed with silylated 4,4′-dihydroxybiphenyl (DHBP) or silylated bisphenol A in N-methylpyrrolidone by means of K2CO3 as catalyst and HF acceptor. At constant concentration (0.08 mol/L) t

The Ortho Effect in the Mass Spectra of Ortho/Para Isomers of Bisphenol A Derivatives and Related Compounds

New examples of the ortho effect in bisphenol A derivatives including interaction of the hydrogen of the ortho-hydroxy group with the neighbouring aromatic ring have been observed.The characteristic ions (+.) (m/z = 134) and (+)