4476-28-2Relevant articles and documents
Photocatalytic Carboxylation of Phenyl Halides with CO2 by Metal-Organic Frameworks Materials
Han, Jianyu,Qiu, Xueying,Su, Lina,Tang, Zhiyong,Zhang, Yin
, p. 312 - 316 (2021/01/04)
In this work, important commercial pharmaceutical intermediates, phenylpropionic acid compounds, are successfully obtained by catalyzing the reaction of carbon dioxide with phenyl halides using MOF-5, a typical metal-organic framework (MOF) material. The influence of temperature, pressure, catalyst type and light on the reaction is investigated, and a 90.3% selectivity towards fluorophenylpropionic acid is reached. Significantly, the catalysts are effective for varied benzyl compounds containing different substituent groups. The catalysts are stable and remain active after three cycles.
Macrolactam Synthesis via Ring-Closing Alkene-Alkene Cross-Coupling Reactions
Goh, Jeffrey,Loh, Teck-Peng,Maraswami, Manikantha
supporting information, p. 9724 - 9728 (2020/12/21)
Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams containing a conjugated diene framework could be easily prepared in high chemoselectivities and Z,E stereoselectivities.
A General, Activator-Free Palladium-Catalyzed Synthesis of Arylacetic and Benzoic Acids from Formic Acid
Wang, Lin,Neumann, Helfried,Beller, Matthias
supporting information, p. 6910 - 6914 (2018/06/04)
A new catalyst for the carboxylative synthesis of arylacetic and benzoic acids using formic acid (HCOOH) as the CO surrogate was developed. In an improvement over previous work, CO is generated in situ without the need for any additional activators. Key to success was the use of a specific system consisting of palladium acetate and 1,2-bis((tert-butyl(2-pyridinyl)phosphinyl)methyl)benzene. The generality of this method is demonstrated by the synthesis of more than 30 carboxylic acids, including non-steroidal anti-inflammatory drugs (NSAIDs), under mild conditions in good yields.
Effect of deuterated solvents toward 2,2,2-trichloroethyl esters with a benzylic methylene moiety
Mineno, Tomoko,Hirayama, Haruyasu,Nakahara, Kazuhide,Yamashita, Mitsuaki,Kansui, Hisao,Moriwaki, Hiroshi
experimental part, p. 6045 - 6048 (2010/11/21)
The indium-promoted chemoselective deprotection of 2,2,2-trichloroethyl esters containing a benzylic methylene was successfully achieved by employing deuterated solvents.
Tri-n-butyltin carboxylate derivatives of para-substituted phenyl-ethanoic acids: Synthesis, characterization and X-ray structure determination
Angiolini, Luigi,Caretti, Daniele,Mazzocchetti, Laura,Salatelli, Elisabetta,Femoni, Cristina
, p. 3301 - 3307 (2007/10/03)
The tributyltin esters of 4-(ethyl)-phenyl-ethanoic acid and 4-(isopropyl)-phenyl-ethanoic acid have been prepared as model compounds of the repeating unit of the related stannylated polystyrenic derivatives. Both the products were fully characterized by proton and carbon NMR two-dimensional techniques. FT-IR spectra show in the solid state carboxylated moieties bridging R 3 Sn groups with the metal atom expanding its coordination number, this structure being destroyed in solution. The supramolecular arrangement of the products in the solid state has been investigated by X-ray diffraction, which confirms the pentacoordination at tin in both the products, and indicates a different spatial arrangement of the alkylated aryl groups, as evidenced also by the slightly different thermal properties.
INHIBITORS OF FUNGAL INVASION
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Drawing sheet 78, (2010/02/09)
This invention relates to various anti-fungall agents including agents that are inhibitors of fungal invasion.
Conformational analysis of some 5-substituted 5H-dibenzo[a,d]-cycloheptenes
Hjelmencrantz, Anders,Friberg, Annika,Berg, Ulf
, p. 1293 - 1300 (2007/10/03)
Conformations and inversion barriers of 5H-dibenzo[a,d]cycloheptene (1a), 5-amino-5H-dibenzo[a,d]cycloheptene (1b), 5-chloro-5H-dibenzo[a,d]cycloheptene (1e), 5-hydroxy-5H-dibenzo[a,d]cycloheptene (1d), 5-methyl-5H-dibenzo[a,d]cycloheptene (1f), N-benzyl-5H-dibenzo[a,d]cyclohepten-5-imine (2) and N-(5H-dibenzo[a,d]cyclohepten-5-yl)benzylideneamine (1c) have been studied by means of dynamic nuclear magnetic resonance spectroscopy (DNMR) techniques, and comparison of the experimentally derived thermodynamic parameters was made with MM3, PM3 and ab initio calculated results. Attempts to determine the inversion barrier of 3-isopropyl-5H-dibenzo[a,d]cyclohepten-5-one (3) failed.
Convenient Preparation of Arylacetic Acids by Tetracarbonylcobaltate Anion Catalysed Carbonylation
Rao, B. Nageswara,Adapa, Srinivas R.,Pardhasaradhi, M.
, p. 84 - 85 (2007/10/02)
Tetracarbonylcobaltate catalyst -, has been prepared in 6 hr by pressure carbonylation of cobalt salt in aq alkaline solution containing cyanide catalyst.Carbonylation of arylchloromethyl derivatives in aq methanolic solutions using this catalyst affords arylacetic acids in good yields.
DEFLUORINATION REACTIONS OF gem-DIFLUORO- AND MONOFLUOROOLEFINS. NOVEL METHODS FOR ONE-CARBON HOMOLOGATIONS OF CARBONYL COMPOUNDS LEADING TO ALDEHYDES, CARBOXYLIC ACIDS, AND ESTERS
Hayashi, Sei-ichi,Nakai, Takeshi,Ishikawa, Nobuo
, p. 651 - 654 (2007/10/02)
Defluorinative hydrolysis (or alcoholysis) of gem-difluoroolefins (1) easily prepared via the facile difluoromethylenation of carbonyl compounds afforded the carboxylic acids (or esters).The homologation method was applied to the synthesis of anti-inflammatory ibuprofen.Furthermore, defluorinative hydrolysis of monofluoroolefins obtained via the reduction of 1 gave the aldehydes.
