470690-99-4

Basic information

• Product Name: [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL
• Synonyms: [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL;[2-Mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol
• CAS NO: 470690-99-4
• Molecular Formula: C₁₂H₁₄N₂O₂S
• Molecular Weight: 250.32
• Mol File: 470690-99-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL(470690-99-4)
• EPA Substance Registry System: [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL(470690-99-4)

Safety Data

• Hazardous Substances Data: 470690-99-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL is used as a building block for the synthesis of new drug compounds due to its unique imidazole ring structure and functional groups, which can be exploited for the development of novel therapeutic agents.
Used in Chemical Industry:
In the chemical industry, [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL may be utilized as a catalyst in various chemical reactions, taking advantage of its reactive mercapto group and other functional moieties to facilitate or enhance specific transformations.
Further research and development are required to fully understand the potential applications and benefits of [2-MERCAPTO-3-(4-METHOXY-BENZYL)-3H-IMIDAZOL-4-YL]-METHANOL in these industries and to optimize its use in practical settings.

Upstream product

• 96-26-4 dihydroxyacetone 
• 333-20-0 potassium thioacyanate 
• 17061-61-9 4-methoxybenzylamine hydrochloride 
• 62147-49-3 1,3-dihydroxyacetone dimer 

Downstream Products

• 470691-03-3 5-hydroxymethyl-1-(4-methoxybenzyl)-2-methylthioimidazole 
• 470691-04-4 [2-ethylsulfanyl-3-(4-methoxy-benzyl)-3H-imidazol-4-yl]-methanol 
• 470691-05-5 [3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-methanol 
• 470691-09-9 3-(4-methoxy-benzyl)-2-methylsulfanyl-3H-imidazole-4-carbaldehyde 
• 470691-10-2 2-ethylsulfanyl-3-(4-methoxy-benzyl)-3H-imidazole-4-carbaldehyde 
• 470691-11-3 3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazole-4-carbaldehyde 
• 470691-15-7 2-azido-3-[3-(4-methoxy-benzyl)-2-methylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester 
• 470691-16-8 2-azido-3-[2-ethylsulfanyl-3-(4-methoxy-benzyl)-3H-imidazol-4-yl]-acrylic acid ethyl ester 
• 470691-17-9 2-azido-3-[3-(4-methoxy-benzyl)-2-propylsulfanyl-3H-imidazol-4-yl]-acrylic acid ethyl ester 

Relevant articles and documents

Preparation of a clinically investigated ras farnesyl transferase inhibitor

The synthesis of ras farnesyl-protein transferase inhibitor 1 is described on a multi-kilogram scale. Retrosynthetic analysis reveals chloromethylimidazole 2 and a piperazinone 3 as viable precursors. The 1,5-disubstituted imidazole system was regioselectively assembled via an improved Marckwald imidazole synthesis. A new imidazole dethionation procedure has been developed to convert the Marckwald mercaptoimidazole product to the desired imidazole. This methodology was found to be tolerant of a variety of functional groups providing good to excellent yields of 1,5-disubstituted imidazoles. A new Mitsunobu cyclization strategy was developed to prepare the arylpiperazinone fragment 3.

Syntheses of substituted pyrrolo[2,3-d]imidazole-5-carboxylates and substitued pyrrolo[3,2-d]imidazole-5-carboxylates

Starting from readily available p-substituted-benzylamines a series of ethyl 2-alkylthio-1-substituted-benzylpyrrolo[2,3-d]imidazole-5-carboxylates was prepared. In addition, starting from 2-alkyl-4(or 5)-formylimidazoles and methyl 4′-bromomethylbiphenyl-2-carboxylate a series of methyl substituted-pyrrolo[2,3-d]imidazole-5-carboxylates and methyl substituted-pyrrolo[3,2-d]imidazole-5-carboxylates was prepared.