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1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine is a chemical compound that belongs to the class of piperazine derivatives. It has a molecular formula C13H20N4O2S and a molecular weight of 300.39 g/mol. 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine is characterized by its thiazolyl and tert-butoxycarbonyl groups, which contribute to its versatile reactivity and functional groups, making it a valuable building block in the synthesis of pharmaceutical drugs and agrochemicals.

474417-23-7

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474417-23-7 Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine is used as an intermediate in the synthesis of pharmaceutical drugs for its ability to modify the physiochemical properties of target molecules. Its presence in the molecular structure can enhance the drug's efficacy, bioavailability, and stability.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine serves as a key intermediate in the production of agrochemicals. Its incorporation into the molecular structure of these chemicals can improve their performance, such as increasing their effectiveness against pests or enhancing their environmental stability.
Overall, 1-(2-Thiazolyl)-4-(tert-butoxycarbonyl)piperazine plays a significant role in medicinal chemistry and drug development due to its versatile reactivity and functional groups, which make it suitable for the creation of biologically active molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 474417-23-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,4,4,1 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 474417-23:
(8*4)+(7*7)+(6*4)+(5*4)+(4*1)+(3*7)+(2*2)+(1*3)=157
157 % 10 = 7
So 474417-23-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H19N3O2S/c1-12(2,3)17-11(16)15-7-5-14(6-8-15)10-13-4-9-18-10/h4,9H,5-8H2,1-3H3

474417-23-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl 4-(thiazol-2-yl)piperazine-1-carboxylate

1.2 Other means of identification

Product number -
Other names tert-butyl 4-(1,3-thiazol-2-yl)piperazine-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:474417-23-7 SDS

474417-23-7Relevant articles and documents

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

Orsi, Douglas L.,Easley, Brandon J.,Lick, Ashley M.,Altman, Ryan A.

supporting information, p. 1570 - 1573 (2017/04/13)

A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.

2-Substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue and preparation method and application thereof

-

Paragraph 0248; 0249; 0250, (2016/10/08)

The invention discloses 2-substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue and a preparation method and application thereof, and particularly, relates to 2-substituted-phenyl-oxy-5-methylsulfonyl piperazine acidamide analogue with a formula (I) compound and a preparation method and application thereof, wherein substitutions in the formula (I) compound are defined as in the description. This serial compound can inhibit the activity of glycine transport protein-1 (GlyT1), is useful in treating related diseases in central nerve and psychological fields, for example, schizophrenia (including positive symptoms, negative symptoms and cognitive symptoms), senile dementia, Parkinson's disease and other related psychological diseases, is widely applicable to the drugs for preventing and treating central nerve and psychological diseases, and is expected to be developed into new-generation GlyT1 inhibitors.

Copper-Catalyzed Electrophilic Amination of Heteroarenes via C-H Alumination

Yoon, Hongju,Lee, Yunmi

, p. 10244 - 10251 (2015/11/03)

A highly efficient Cu-catalyzed electrophilic amination reaction of readily available heteroarenes with O-benzoyl hydroxylamines via a one-pot C-H alumination is reported. The reactions were catalyzed using 1 mol % of CuCl to afford various heteroaryl amines in good to excellent yields. The direct C-H lithiation/transalumination of heteroarenes and catalytic amination sequence can be performed in a single vessel on gram scales.

HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS

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Page/Page column 216, (2009/01/23)

Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

ACETYLENE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS

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Page/Page column 56, (2008/12/05)

The present invention provides Stearoyl CoA Desaturase (SCD) inhibitors, hi particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase 1 (SCD 1) inhibitors. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase (SCD) inhibitors.

POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS

-

Page/Page column 250, (2008/06/13)

Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use

-

Page/Page column 39, (2010/02/08)

The invention relates to compounds of formula: and also to the salts thereof with mineral or organic acids, and the solvates and/or hydrates thereof, with affinity for and selectivity towards the arginine-vasopressin V1b receptors and/or for the ocytocin receptors and, furthermore, for certain compounds, affinity for the V1a receptors. The invention also relates to the process for preparing them, to the intermediate compounds of formula (IV) that are useful for preparing them, to pharmaceutical compositions containing them and to their use for preparing medicinal products.

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