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1,4-Anhydro-L-ribitol is a naturally occurring sugar alcohol, also known as L-ribitol or D-ribitol, depending on the naming convention used. It is a pentitol, meaning it contains five hydroxyl groups, and is derived from the sugar ribose. 1,4-ANHYDRO-L-RIBITOL is widely found in nature and is often used as a starting material for the synthesis of various biologically active compounds.

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  • 51607-76-2 Structure
  • Basic information

    1. Product Name: 1,4-ANHYDRO-L-RIBITOL
    2. Synonyms: 1,4-ANHYDRO-L-RIBITOL
    3. CAS NO:51607-76-2
    4. Molecular Formula: C5H10O4
    5. Molecular Weight: 134.13
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 51607-76-2.mol
  • Chemical Properties

    1. Melting Point: 99 °C
    2. Boiling Point: 140 °C(Press: 0.1 Torr)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.453±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 13.72±0.60(Predicted)
    10. CAS DataBase Reference: 1,4-ANHYDRO-L-RIBITOL(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1,4-ANHYDRO-L-RIBITOL(51607-76-2)
    12. EPA Substance Registry System: 1,4-ANHYDRO-L-RIBITOL(51607-76-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 51607-76-2(Hazardous Substances Data)

51607-76-2 Usage

Uses

1. Used in Pharmaceutical Industry:
1,4-Anhydro-L-ribitol is used as a starting material for the synthesis of various pharmaceutical compounds. Its unique structure and multiple hydroxyl groups make it a versatile building block for the development of new drugs.
2. Used in Chemical Synthesis:
1,4-Anhydro-L-ribitol is used as a reactant in the synthesis and study of various organic compounds, including fluorobenzene and benzimidazole nucleic-acid analogs. It plays a crucial role in understanding the influence of these analogs on the stability of RNA duplexes.
3. Used in Research and Development:
Due to its structural similarities with ribose, 1,4-anhydro-L-ribitol is often utilized in research to study the properties and functions of ribose-containing biomolecules. This includes investigations into the structure and function of RNA and other ribose-containing compounds.
4. Used in the Synthesis of Chiral Compounds:
1,4-Anhydro-L-ribitol's chiral nature makes it a valuable compound for the synthesis of chiral molecules, which are essential in various applications, including the development of enantiomerically pure drugs.
5. Used in the Production of Bioactive Compounds:
1,4-Anhydro-L-ribitol is used as a precursor in the production of bioactive compounds, such as nucleosides, nucleotides, and other ribose-containing molecules with potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 51607-76-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,6,0 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 51607-76:
(7*5)+(6*1)+(5*6)+(4*0)+(3*7)+(2*7)+(1*6)=112
112 % 10 = 2
So 51607-76-2 is a valid CAS Registry Number.

51607-76-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4-ANHYDRO-L-RIBITOL

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:51607-76-2 SDS

51607-76-2Relevant articles and documents

Hydrodeoxygenation of C4-C6 sugar alcohols to diols or mono-alcohols with the retention of the carbon chain over a silica-supported tungsten oxide-modified platinum catalyst

Betchaku, Mii,Cao, Ji,Liu, Lujie,Nakagawa, Yoshinao,Tamura, Masazumi,Tomishige, Keiichi,Yabushita, Mizuho

supporting information, p. 5665 - 5679 (2021/08/16)

The hydrodeoxygenation of erythritol, xylitol, and sorbitol was investigated over a Pt-WOx/SiO2 (4 wt% Pt, W/Pt = 0.25, molar ratio) catalyst. 1,4-Butanediol can be selectively produced with 51% yield (carbon based) by erythritol hydrodeoxygenation at 413 K, based on the selectivity over this catalyst toward the regioselective removal of the C-O bond in the -O-C-CH2OH structure. Because the catalyst is also active in the hydrodeoxygenation of other polyols to some extent but much less active in that of mono-alcohols, at higher temperature (453 K), mono-alcohols can be produced from sugar alcohols. A good total yield (59%) of pentanols can be obtained from xylitol, which is mainly converted to C2 + C3 products in the literature hydrogenolysis systems. It can be applied to the hydrodeoxygenation of other sugar alcohols to mono-alcohols with high yields as well, such as erythritol to butanols (74%) and sorbitol to hexanols (59%) with very small amounts of C-C bond cleavage products. The active site is suggested to be the Pt-WOx interfacial site, which is supported by the reaction and characterization results (TEM and XAFS). WOx/SiO2 selectively catalyzed the dehydration of xylitol to 1,4-anhydroxylitol, whereas Pt-WOx/SiO2 promoted the transformation of xylitol to pentanols with 1,3,5-pentanetriol as the main intermediate. Pre-calcination of the reused catalyst at 573 K is important to prevent coke formation and to improve the reusability.

IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY

-

Paragraph 00309, (2021/01/23)

The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) Wherein R1 includes an amino group. These compounds are particularly useful in the formulation and in vivo and ex vivo delivery of nucleic acid and protein therapeutics for preparing and implementing T cell transfection, gene editing, cancer therapies, cancer prophylactics, and in the preparation of vaccines.

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

-

Paragraph 0057; 0349, (2021/06/22)

Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

Synthesis of novel carbohydrate based pyridinium ionic liquids and cytotoxicity of ionic liquids for mammalian cells

Brietzke, Andreas,Eickner, Thomas,Jopp, Stefan,Kragl, Udo,Rei?, Melanie,Stein, Florian,Villinger, Alexander,Vogel, Christian

, p. 14299 - 14304 (2020/04/23)

The large pool of naturally occurring carbohydrates with their diversity in chirality and structure led to the idea of a systematic investigation of carbohydrate based ILs. To this end, we investigated the influence of different ether groups, mainly methyl or ethyl ether, on the secondary OH groups as well as different configurations on physical properties such as melting point, thermostability and especially the influence on cell toxicity. For this investigation we chose α- and β-methyl-, β-allyl- and β-phenyl d-glucopyranose as well as four 1-deoxy-pentoses. In order to be able to classify the results, more ionic liquids with different structural motives were examined for cytotoxicity. Here, we present data that confirm the biocompatibility of such ILs consisting of naturally occurring molecules or their derivatives. The synthesized carbohydrate based ILs were tested for their suitability as additives in coatings for medical applications such as drug-eluting balloons.

Functionalised tetrahydrofuran fragments from carbohydrates or sugar beet pulp biomass

Benhamou, Laure,Foster, Robert W.,Ward, David P.,Wheelhouse, Katherine,Sloan, Lisa,Tame, Christopher J.,Bu?ar, Dejan-Kre?imir,Lye, Gary J.,Hailes, Helen C.,Sheppard, Tom D.

supporting information, p. 2035 - 2042 (2019/04/29)

Carbohydrate biomass represents a potentially valuable sustainable source of raw materials for chemical synthesis, but for many applications, selective deoxygenation/dehydration of the sugars present is necessary to access compounds with useful chemical and physical properties. Selective dehydration of pentose sugars to give tetrahydrofurans can be achieved by treatment of the corresponding N,N-dimethylhydrazones under acidic or basic conditions, with the two approaches showing complementary stereoselectivity. The dehydration process is readily scalable and the THF hydrazones derived from arabinose, ribose, xylose and rhamnose were converted into a range of useful fragments containing primary alcohol, ketone, carboxylic acid or amine functional groups. These compounds have potentially useful physiochemical properties making them suitable for incorporation into fragment/lead generation libraries for medicinal chemistry. It was also shown that l-arabinose hydrazone could be obtained selectively from a crude sample of hydrolysed sugar beet pulp.

Controlling Sugar Deoxygenation Products from Biomass by Choice of Fluoroarylborane Catalyst

Seo, Youngran,Lowe, Jared M.,Gagné, Michel R.

, p. 6648 - 6652 (2019/08/26)

The feedstocks from biomass are defined and limited by nature, but through the choice of catalyst, one may change the deoxygenation outcome. We report divergent but selective deoxygenation of sugars with triethylsilane (TESH) and two fluoroarylborane catalysts, B(C6F5)3 and B(3,5-CF3)2C6H3)3 (BAr3,5-CF3). To illustrate, persilylated 2-deoxyglucose shows exocyclic C-O bond cleavage/reduction with the less sterically congested BAr3,5-CF3, whereas endocyclic C-O bond cleavage/reduction predominates with the more Lewis acidic B(C6F5)3. Chiral furans and linear polyols can be selectively synthesized depending on the catalysts. Mechanistic studies demonstrate that the resting states of these catalysts are different.

Intramolecular dehydration of biomass-derived sugar alcohols in high-temperature water

Yamaguchi, Aritomo,Muramatsu, Natsumi,Mimura, Naoki,Shirai, Masayuki,Sato, Osamu

, p. 2714 - 2722 (2017/08/17)

The intramolecular dehydration of biomass-derived sugar alcohols d-sorbitol, d-mannitol, galactitol, xylitol, ribitol, l-arabitol, erythritol, l-threitol, and dl-threitol was investigated in high-temperature water at 523-573 K without the addition of any acid catalysts. d-Sorbitol and d-mannitol were dehydrated into isosorbide and isomannide, respectively, as dianhydrohexitol products. Galactitol was dehydrated into anhydrogalactitols; however, the anhydrogalactitols could not be dehydrated into dianhydrogalactitol products because of the orientation of the hydroxyl groups at the C-3 and C-6 positions. Pentitols such as xylitol, ribitol, and l-arabitol were dehydrated into anhydropentitols. The dehydration rates of the pentitols containing hydroxyl groups in the trans form, which remained as hydroxyl groups in the product tetrahydrofuran, were larger than those containing hydroxyl groups in the cis form because of the structural hindrance caused by the hydroxyl groups in the cis form during the dehydration process. In the case of the tetritols, the dehydration of erythritol was slower than that of threitol, which could also be explained by the structural hindrance of the hydroxyl groups. The dehydration of l-threitol was faster than that of dl-threitol, which implies that molecular clusters were formed by hydrogen bonding between the sugar alcohols in water, which could be an important factor that affects the dehydration process.

Xylitol Hydrogenolysis over Ruthenium-Based Catalysts: Effect of Alkaline Promoters and Basic Oxide-Modified Catalysts

Rivière, Maxime,Perret, Noémie,Cabiac, Amandine,Delcroix, Damien,Pinel, Catherine,Besson, Michèle

, p. 2145 - 2159 (2017/06/28)

The aqueous-phase hydrogenolysis of xylitol into glycols over Ru/C was performed in the presence and absence of a wide range of concentrations of Ca(OH)2 to investigate the reaction pathway. Without base, epimerization and cascade decarbonylation were the predominant reactions with high selectivities to C5 and C4 alditols and light alkanes at full conversion. Glycol production was obtained by the addition of Ca(OH)2 to promote the retro-aldol reaction. It competed with reactions without base and became the main reaction for a OH?/ xylitol molar ratio Rmol(OH/xylitol) of 0.13, and high selectivities to glycols (56 %) and glycerol (16 %) were observed. However, lactate was a byproduct at up to 27 % with a high base amount (Rmol(OH/xylitol)=0.68). Bifunctional Ru/metal oxide/C catalysts (metal: Zn, Sn, Mn, Sr, W) were synthesized and were able to cleave the C?C bond into glycols without a base promoter. The 3.1 wt %Ru/MnO(4.5 %)/C catalyst was the most active (220 h?1) with reasonable selectivity to glycols (22 %) and glycerol (10 %) and a low production of lactate (1 %). Nevertheless, metal oxide leaching of the catalyst was observed likely because of the production of traces of lactate.

Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypanocidal activity

Elias, Paula Regina,Coelho, Gleicekelly Silva,Xavier, Viviane Flores,Sales, Policarpo Ademar,Romanha, Alvaro José,Murta, Silvane Maria Fonseca,Carneiro, Claudia Martins,Camilo, Nilton Soares,Hilário, Flaviane Francisco,Taylor, Jason Guy

, (2016/11/06)

A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-Triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as positive control against T. cruzi and cytotoxicity was determined in mammalian L929 cells. The arylsulfonate xylitan derivative bearing a nitro group displayed the best activity of all the compounds tested, and was slightly more potent than the reference drug benznidazole. The importance of the isopropylidene ketal moiety was established and the greater lipophilicity of these compounds suggests enhancement in cell penetration.

Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses

Foster, Robert W.,Tame, Christopher J.,Bu?ar, Dejan-Kre?imir,Hailes, Helen C.,Sheppard, Tom D.

supporting information, p. 15947 - 15950 (2015/11/03)

L-Arabinose is an abundant resource available as a waste product of the sugar beet industry. Through use of a hydrazone-based strategy, L-arabinose was selectively dehydrated to form a chiral tetrahydrofuran on a multi-gram scale without the need for protecting groups. This approach was extended to other biomass-derived reducing sugars and the mechanism of the key cyclization investigated. This methodology was applied to the synthesis of a range of functionalized chiral tetrahydrofurans, as well as a formal synthesis of 3R-3-hydroxymuscarine.

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