488-81-3Relevant articles and documents
L-xylo-3-hexulose reductase is the missing link in the oxidoreductive pathway for D-galactose catabolism in filamentous fungi
Mojzita, Dominik,Herold, Silvia,Metz, Benjamin,Seiboth, Bernhard,Richard, Peter
, p. 26010 - 26018 (2012)
In addition to the well established Leloir pathway for the catabolism of D-galactose in fungi, the oxidoreductive pathway has been recently identified. In this oxidoreductive pathway, D-galactose is converted via a series of NADPH-dependent reductions and NAD+-dependent oxidations into D-fructose. The pathway intermediates include galactitol, L-xylo-3-hexulose, and D-sorbitol. This study identified the missing link in the pathway, the L-xylo-3-hexulose reductase that catalyzes the conversion of L-xylo-3-hexulose to D-sorbitol. In Trichoderma reesei (Hypocrea jecorina) and Aspergillus niger, we identified the genes lxr4 and xhrA, respectively, that encode the L-xylo-3-hexulose reductases. The deletion of these genes resulted in no growth on galactitol and in reduced growth on D-galactose. The LXR4 was heterologously expressed, and the purified protein showed high specificity for L-xylo-3-hexulose with a Km=2.0±0.5mM and a V max=5.5±1.0 units/mg. We also confirmed that the product of the LXR4 reaction is D-sorbitol.
Electrolytic reduction of D-ribonolactone with controlled cathode potential
Matsumoto,Miyazaki
, p. 864 - 866 (1966)
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COMPOSITIONS AND METHODS OF MAKING RIBITOL
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Page/Page column 17, (2020/12/11)
The present disclosure describes compositions comprising substantially pure ribitol, pharmaceutical compositions of ribitol, and methods of making ribitol. The methods may include combining a reducing agent (e.g., borohydride) and ribose (e.g. D-ribose), optionally with stirring, to form a first reaction mixture; and contacting the first reaction mixture and an acidic quenching agent, optionally with stirring, to form a second reaction mixture, thereby forming ribitol.
Hydrogenolysis of sorbitol into valuable C3-C2 alcohols at low H2 pressure promoted by the heterogeneous Pd/Fe3O4 catalyst
Gumina, Bianca,Mauriello, Francesco,Pietropaolo, Rosario,Galvagno, Signorino,Espro, Claudia
, p. 152 - 160 (2018/02/17)
The hydrogenolysis of sorbitol and various C5-C3 polyols (xylitol; erythritol; 1,2- 1,4- and 2,3-butandiol; 1,2-propandiol; glycerol) have been investigated at low molecular hydrogen pressure (5 bar) by using Pd/Fe3O4, as heterogeneous catalyst and water as the reaction medium. Catalytic experiments show that the carbon chain of polyols is initially shortened through dehydrogenation/decarbonylation and dehydrogenation/retro-aldol mechanisms followed by a series of cascade reactions that include dehydrogenation/decarbonylation and dehydration/hydrogenation processes. At 240 °C, sorbitol is fully converted into lower alcohols with ethanol being the main reaction product in liquid phase.
