524714-06-5

Basic information

• Product Name: (2S,3E)-4-Bromo-1-(4-fluorophenoxy)-3-buten-2-ol
• Synonyms: (2S,3E)-4-Bromo-1-(4-fluorophenoxy)-3-buten-2-ol
• CAS NO: 524714-06-5
• Molecular Formula: C₁₀H₁₀BrFO₂
• Molecular Weight: 261.0876032
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 524714-06-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S,3E)-4-Bromo-1-(4-fluorophenoxy)-3-buten-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3E)-4-Bromo-1-(4-fluorophenoxy)-3-buten-2-ol(524714-06-5)
• EPA Substance Registry System: (2S,3E)-4-Bromo-1-(4-fluorophenoxy)-3-buten-2-ol(524714-06-5)

Safety Data

• Hazardous Substances Data: 524714-06-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2S,3E)-4-Bromo-1-(4-fluorophenoxy)-3-buten-2-ol is used as an intermediate in the preparation of Lipoxin analogs for the pharmaceutical industry. Lipoxins are bioactive molecules that play a crucial role in the resolution of inflammation and have potential therapeutic applications in various inflammatory diseases. (2S,3E)-4-Bromo-1-(4-fluorophenoxy)-3-buten-2-ol's unique structure allows it to be a key component in the synthesis of these valuable analogs, contributing to the development of new drugs targeting inflammation-related conditions.
Used in Chemical Synthesis:
(2S,3E)-4-Bromo-1-(4-fluorophenoxy)-3-buten-2-ol can also be utilized as a building block in the synthesis of other complex organic molecules, particularly in the field of chemical research and development. Its distinct functional groups and structural features make it a valuable starting material for creating novel compounds with potential applications in various industries, such as agrochemicals, materials science, and specialty chemicals.

Upstream product

• 67693-57-6 4-(p-fluorophenoxy)-3-hydroxy-1-butyne 
• 119119-56-1 E-2-(tri-n-butylstannyl)vinyllithium 
• 524714-05-4 (3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butyne 
• 371-41-5 4-Fluorophenol 
• 59769-38-9 2-(4-fluorophenoxy)acetaldehyde 
• 405-90-3 3-(4-Fluorophenoxy)-1,2-propanediol 
• 620973-10-6 1-(4-fluoro-phenoxy)-4-trimethylsilanyl-but-3-yn-2-ol 

Downstream Products

• 524714-14-5 1,1-dimethylethyl [[(2S,3R)-3-[(1E,3E,7E,9S)-10-(4-fluorophenoxy)-9-hydroxyl-1,3,7-decatrien-5-ynyl]-1,4-dioxaspiro[4,5]dec-2-yl]methoxy]ethanoate 
• 620973-06-0 (7E,9E,13E)-(5S,6R,15S)-16-(4-Fluoro-phenoxy)-5,6,15-trihydroxy-hexadeca-7,9,13-trien-11-ynoic acid methyl ester 
• 524714-15-6 (5S,6R,7E,9E,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-3-oxahexadeca-7,9,13-trien-11-ynoic acid, t-butyl ester 
• 524714-13-4 2-(((2S,3R,4E,6E,10E,12S)-13-(4-fluorophenoxy)-2,3,12-trihydroxytrideca-4,6,10-trien-8-yn-1-yl)oxy)acetic acid 
• 620973-14-0 4-{(4S,5R)-5-[(1E,3E,7E)-(S)-10-(4-Fluoro-phenoxy)-9-hydroxy-deca-1,3,7-trien-5-ynyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-butyric acid methyl ester 

Relevant articles and documents

Novel 3-Oxa Lipoxin A4 Analogues with Enhanced Chemical and Metabolic Stability Have Anti-inflammatory Activity in Vivo

Lipoxin A4 (LXA4) is a structurally and functionally distinct natural product called an eicosanoid, which displays immunomodulatory and anti-inflammatory activity but is rapidly metabolized to inactive catabolites in vivo. A previous

Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, an analogue of 15R-lipoxin A4

We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A4.