54921-72-1

Basic information

• Product Name: Phosphonic acid, monophenyl ester, ammonium salt
• CAS NO: 54921-72-1
• Molecular Formula: C6H7O3P.H3N
• Molecular Weight: 175.124
• Mol File: 54921-72-1.mol

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, monophenyl ester, ammonium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, monophenyl ester, ammonium salt(54921-72-1)
• EPA Substance Registry System: Phosphonic acid, monophenyl ester, ammonium salt(54921-72-1)

Safety Data

• Hazardous Substances Data: 54921-72-1(Hazardous Substances Data)

Usage

Uses

Used in Water Treatment:
Phosphonic acid, monophenyl ester, ammonium salt is used as a chelating agent for the purpose of binding and neutralizing metal ions such as calcium and magnesium in water. This action prevents scale formation and corrosion in industrial equipment and piping systems, thereby maintaining the efficiency and longevity of water treatment processes.
Used in Metal Processing:
In the metal processing industry, phosphonic acid, monophenyl ester, ammonium salt serves as a corrosion inhibitor. It protects metal surfaces from degradation and prolongs the service life of metal components and machinery by preventing the corrosive effects of metal ions.
Used in Agricultural Formulations:
Phosphonic acid, monophenyl ester, ammonium salt is utilized as an additive in agricultural formulations to enhance the effectiveness of these products. Its chelating properties can improve the uptake of nutrients by plants and its compatibility with other chemicals allows for the creation of more efficient and targeted agricultural solutions.
Overall, the applications of phosphonic acid, monophenyl ester, ammonium salt contribute to the optimization of industrial processes and the preservation of infrastructure through its chelating and corrosion-inhibiting properties.

Upstream product

• 4712-55-4 diphenyl hydrogen phosphite 
• 108-95-2 phenol 
• 101-02-0 triphenyl phosphite 

Downstream Products

• 137862-40-9 phenyl bis(trimethylsilyl) phosphite 
• 130288-82-3 C₁₅H₂₇O₆P 
• 180906-74-5 C₁₆H₂₃O₅P 
• 180906-75-6 C₁₁H₁₅O₄P 
• 101-02-0 triphenyl phosphite 
• 33214-13-0 tetraphenyl pyrophosphite 
• 2161-16-2 phosphorous acid ethyl ester-diphenyl ester 
• 14609-90-6 phenyl isopropyl H-phosphonate 
• 20442-56-2 ethyl phenyl H-phosphonate 
• 4712-55-4 diphenyl hydrogen phosphite 

Relevant articles and documents

Bisphosphonate prodrugs: Synthesis of new aromatic and aliphatic 1-hydroxy-1,1-bisphosphonate partial esters

Methods for the preparation of various 1-hydroxy-1,1-bisphosphonate partial esters were developed. They were obtained from (alkyl or phenyl) bis(trimethylsilyl) phosphite and aromatic or aliphatic acid chlorides, followed by methanolysis.

High yield protection of purine ribonucleosides for phosphoramidite RNA synthesis

We report high yield procedures for protection of purine ribonucleosides based on a reaction which allows concomitant highly regiospecific 2'-silylation and 3'-phosphitylation. Subsequent cleavage of the H-phosphonate monoester moiety without silyl migration provides intermediates ready for phosphitylation by standard methods to give fully protected phosphoramidites.

Use of ammonium aryl H-phosphonates in the preparation of nucleoside H-phosphonate building blocks

Ammonium 4-methylphenyl H-phosphonate 4c was used in the conversion of 5'-0-(dimethoxy-trityl)-2'-deoxynucleoside derivatives 6 into the corresponding 3'-H-phosphonates 2, which were isolated in a high state of purity and in high yield.

Studies on aryl H-phosphonates. 3. Mechanistic investigations related to the disproportionation of diphenyl H-phosphonate under anhydrous basic conditions

Diphenyl H-phosphonate undergoes under anhydrous reaction conditions a base-promoted disproportionation to triphenyl phosphite and phenyl H- phosphonate. On the basis of 31P NMR data the most likely mechanism for this transformation was proposed. In order to substantiate these findings and to get a deeper insight into the chemistry of aryl H-phosphonate esters, we carried out also some studies on activation of phenyl and diphenyl H- phosphonates with various condensing agents. We found that aryl vs alkyl esters of phosphonic acid often follow different reaction pathways during the activation, and this can most likely be traced back to higher electrophilicity of the phosphorus centre and to higher reactivity of the P- H bonds in aryl H-phosphonate derivatives.